Prevention of vascular nitroglycerin tolerance by inhibition of protein kinase C

British Journal of Pharmacology

Volumn 119, Issue 1, 1996, Pages 3-5

  Zierhut, Wolfgang ^a   Ball, Howard A ^a  

^a Preclinical Research   (Switzerland)

Author keywords

Nitroglycerin tolerance; Protein kinase C inhibition

Indexed keywords

GLYCERYL TRINITRATE; PROTEIN KINASE C; STAUROSPORINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG TOLERANCE; ENZYME INHIBITION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029815624     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15669.x     Document Type: Article

References (5)

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2. HUSAIN, M., ADRIE, C., ICHINOSE, F., KAVOSI, M. & ZAPOL, W.M. (1994). Exhaled nitric oxide as a marker for organic nitrate tolerance. Circulation, 89, 2498 - 502.
3. MARTE, B.M., MEYER, T., STABEL, S., STANDKE, G.J.R., JAKEN, S., FABBRO, D. & HYNES, N.E. (1994). Protein kinase C and mammary cell differentiation: involvement of protein kinase C alpha in the induction of β-casein expression. Cell Growth Differ., 5, 239 - 247.
4. MÜNZEL, T., GIAID, A., KURZ, S., STEWART, D.J. & HARRISON, D.G. (1995). Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. Proc. Natl. Acad. Sci. U.S.A., 92, 5244 - 5248.
5. NEEDLEMAN, P. (1970). Tolerance to the vascular effects of glyceryl trinitrate. J. Pharmacol. Exp. Ther., 171, 98 - 102.