The heat shock/oxidative stress connection: Relevance to Alzheimer disease

Molecular and Chemical Neuropathology

Volumn 28, Issue 1-3, 1996, Pages 21-34

  Pappolla, M A ^a   Sos, M ^a   Omar, R A ^b   Sambamurti, K ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

aging; Alzheimer disease; antioxidant enzymes; Free radical oxidations; heat shock; heat shock proteins; neurofibrillary tangles; oxidative stress; senile plaques

Indexed keywords

FREE RADICAL; HEAT SHOCK PROTEIN;

AGING; ALZHEIMER DISEASE; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; CONFERENCE PAPER; HEAT SHOCK; HUMAN; HUMAN TISSUE; MAMMAL; NEUROFIBRILLARY TANGLE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PURIFICATION; QUALITATIVE DIAGNOSIS; SENILE PLAQUE;

ANIMALIA; MAMMALIA;

EID: 0029815607     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815201     Document Type: Conference Paper

References (13)

1. Andorn A. C., Britton R., and Bacon B. (1990) Evidence that lipid peroxidation and total iron are increased in Alzheimer's brain. Neurobiol. Aging 11, 316 (abstract).
2. Baler R., Welch W. J., and Voellmy R. (1992) Heat shock-gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential auto-regulatory factor. J. Cell. Biol. 117, 1151-1159.
3. Brown I. R. (1994) Induction of heat shock genes in the mammalian brain by hyperthermia and tissue injury, in Heat Shock Proteins in the Nervous System (Mayer R. J. and Brown I. R., eds.), Academic, San Diego.
4. Brown I. R. and Rush S. J. (1990) Expression of heat shock genes (hsp70) in the mammalian brain: Distinguishing constitutively expressed and hyperthermia-inducible mRNA species. J. Neurosci. Res. 25, 14-19.
5. Brown I. R., Cosgrove J. W., and Clark B. D. (1982) Physiologically relevant increases in body temperature induce the synthesis of a heat shock protein in mammalian brain and other organs, in Heat Shock from Bacteria to Man (Schlesinger M. J., Ashburner M., and Tissieres A., eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 361-367.
6. Burdick D., Soreghan B., Kwon M., Kosmoski J., Knauer M., Henschen A., Yates J., Cotman C., and Glabe C. (1992) Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs. J. Biol. Chem. 267, 546-554.
7. Burdon R. H., GUI V., and Rice-Evans C. (1987) Oxidative stress and heat shock protein induction in human cells. Free Radical Res. Commun. 3, 129-139.
8. Buxbaum J. D., Oishi M., Chen H. I., Pinkas-Kramarski R., Jaffe E. A., Gandy S. E., and Greengard P. (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA 89, 10,075-10,078.
9. Cataldo M. and Nixon R. A. (1990) Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc. Natl. Acad. Sci. USA 87, 3861-3865.
10. Chen L., Richardson J. S., Caldwell J. E., and Ang L. C. (1994) Regional brain activity of free radical defense enzymes in autopsy samples from patients with Alzheimer's disease and from nondemented controls. Int. J. Neurosci. 75, 83-90.
11. Cole G. M. and Timiras P. S. (1987) Ubiquitin-protein conjugates in Alzheimer's lesions. Neurosci. Lett. 18, 207-212.
12. De Keyser J., Ebinger G., and Vanguelin G. (1990) D1-receptor abnormality in frontal cortex points to a functional alteration of cortical cell membranes in Alzheimer's disease. Arch. Neurol. 47, 761-763.
13. DeStropper B., Umans L., VanLeuven F., and Van Den Berghe H. (1993) Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): Cleavage occurs in a compartment of the default secretory pathway. J. Cell. Biol. 121, 295-304.