Rational design, recombinant preparation, and in vitro and in vivo characterization of human prothrombin-derived hirudin antagonists

Journal of Biological Chemistry

Volumn 271, Issue 39, 1996, Pages 23737-23742

  Fischer, Bernhard E ^a   Schlokat, Uwe ^a   Mitterer, Artur ^a   Savidis Dacho, Helga ^a   Grillberger, Leopold ^a   Reiter, Manfred ^a   Mundt, Wolfgang ^a   Dorner, Friedrich ^a   Eibl, Johann ^a  

^a BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

D419N MEIZOTHROMBIN; D419N THROMBIN; HIRUDIN; PROTHROMBIN; THROMBIN; THROMBIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; CHO CELL; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL;

ANIMALS; BLOOD COAGULATION; CHO CELLS; CRICETINAE; DRUG DESIGN; HIRUDINS; HUMANS; POINT MUTATION; PROTEIN BINDING; PROTHROMBIN; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; ECHIS CARINATUS; OXYURANUS SCUTELLATUS;

EID: 0029815509     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.39.23737     Document Type: Article

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