Acidosis accentuates thiopental-induced myocardial depression in vitro

Anesthesia and Analgesia

Volumn 83, Issue 3, 1996, Pages 636-638

  Thurston, Timothy A ^a   Maldonado, Guadelupe ^a   Mathew, Babu P ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; HEART MUSCLE DEPRESSANT FACTOR; PROPRANOLOL; THIOPENTAL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE RELAXATION; METABOLIC ACIDOSIS; METABOLIC ALKALOSIS; NONHUMAN; PH; PRIORITY JOURNAL; RAT; RESPIRATORY ACIDOSIS;

EID: 0029815448     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-199609000-00036     Document Type: Article

References (7)

1. Narahashi T, Frazier DT, Deguchi T, et al. The active form of pentobarbital in squid giant axons. J Pharmacol Exp Ther 1971;177:25-33.
2. Blinks JR. Field stimulation as a means of effecting the graded release of autonomic transmitters in isolated heart muscle. J Pharmacol Exp Ther 1966;151:221-35.
3. Lindmar R, Loffelholz K, Weide W. Inhibition by pentobarbital of the acetylcholine release from the postganglionic parasympathetic neuron of the heart. J Pharmacol Exp Ther 1979;210:166-73.
4. Korten K, Miller KW. Erythrocyte ghost-buffer partition coefficients of phenobarbital, pentobarbital, and thiopental support the pH-partition hypothesis. Can J Physiol Pharmacol 1979;57:325-8.
5. Dayton PG, Perel JM, Landrau MA, et al. The relationship between binding of thiopental to plasma and its distribution into adipose tissue in man, as measured by a spectrophotoflurometric method. Biochem Pharmacol 1967;16:2321-6.
6. Christensen JH, Andreasen F, Jensen EB. The binding of thiopental to human serum albumin at variable pH and temperature. Acta Pharmacol Toxicol 1983;2:364-70.
7. The question of intravenous anesthesia in war surgery [editorial]. Anesthesiology 1943;4:74-7.