In vivo bystander effect in the intracranial model with rat glioma cells reflects the clonal difference of HSV-TK positive cells

International Journal of Oncology

Volumn 9, Issue 3, 1996, Pages 521-525

  Iwadate, Yasuo ^a   Namba, Hiroki ^b   Tagawa, Masatoshi ^a   Takenaga, Keizo ^b   Sueyoshi, Kanji ^b   Sakiyama, Shigeru ^b  

^a CHIBA UNIVERSITY   (Japan)

^b CHIBA CANCER CENTER   (Japan)

Author keywords

bystander effect; glioblastoma; herpes simplex virus; magnetic resonance imaging; thymidine kinase

Indexed keywords

ANTINEOPLASTIC AGENT; VIRUS ENZYME;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CELL DENSITY; CONTROLLED STUDY; DRUG TRANSPORT; ENZYME ANALYSIS; GENE THERAPY; GLIOSARCOMA; HERPES SIMPLEX VIRUS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029815349     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.9.3.521     Document Type: Article

References (22)

1. Mahaley MS Jr, Mettlin C, Natarajan N, Laws ER and Peace BB: National survey of patterns of care for brain-tumor patients J Neurosurg 71: 826-836, 1989.
2. Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U Brooks WH, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr Owens G, Ransohoff JH, Robertson JT, Shapiro WR, Smith KR Jr, Wilson CB and Strike TA: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303: 1323-1329, 1980.
3. Takamiya Y, Short P, Moolten FL, Fleet C, Mineta T, Breakefield XO and Martuza RL: An experimental model of retrovirus gene therapy for malignant brain tumors. J Neurosurg 79: 104-110, 1993.
4. Chen S-H, Shine HD, Goodman JC, Grossman RG and Woo SLC: Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 91: 3054-3057, 1994.
5. Freeman SM, Abbound CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL and Abraham GN: The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 53: 5274-5283, 1993.
6. Bi WL, Parysek LM, Warnick R and Stambrook PJ: In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum Gene Ther 4: 725-731, 1993.
7. Samejima Y and Meruelo D: Bystander killing induces apoptosis and is inhibited by forskolin. Gene Ther 2: 50-58, 1995.
8. Colombo BM, Benedetti S, Ottolenghi S, Mora M, Pollo B, Poli G and Finocchiaro G: The 'bystander effect': association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in a thymic mice. Hum Gene Ther 6: 763-772, 1995.
9. Cignetti A, Guarini A, Carbone A, Forni M, Cronin K, Forni G, Gansbacher B and Foa R: Transaction of the IL2 gene into human acute leukemia cells: induction of tumor rejection without modifying cell proliferation and IL2 receptor expression. J Natl Cancer Inst 86: 785-791, 1994.
10. Fyfe JA, Keller PM, Furman PA, Miller RL and Elion GB: Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethy) guanine. J Biol Chem 253: 8721-8727, 1978.
11. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
12. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods 65: 55-63, 1983.
13. Wu JK, Cano WG, Meylaerts SAG, Qi P, Vrionis F and Cherington V: Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 35: 1094-1103, 1994.
14. Barba D, Hardin J, Ray J and Gage FH: Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg 79: 729-735, 1993.
15. Ram Z, Walbridge S, Heiss JD, Culver KW, Blaese RM and Oldfield EH: In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors. J Neurosurg 80: 535-540, 1994.
16. Barba D, Hardin J, Sadelain M and Gage FH: Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 91: 4348-4352, 1994.
17. Chen C-Y, Chang Y-N, Ryan P, Linscott M, McGarrity GJ and Chiang YL: Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the 'bystander effect'. Hum Gene Ther 6: 1467-1476, 1995.
18. Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH and Blaese RM: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256: 1550-1552, 1992.
19. Ram Z, Culver KW, Wallbridge S, Blaese RM and Oldfield EH: In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 53: 83-88, 1993.
20. Oldfield EH: Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 4: 39-69, 1993.
21. Maron A, Gustin T, Mottet I, Demeure R and Octave JN: Ganciclovir mediated regression of rat brain tumors expressing the herpes simplex virus thymidine kinase imaged by magnetic resonance. J Neuro-Oncol 24: 259-265, 1995.
22. Izquierdo M, Cortés M, de Felipe P, Martín V, Díez-Guerra J, Talavera A and Petez-Higueras A: Long-term rat survival after malignant brain tumor regression by retroviral gene therapy. Gene Ther 2: 66-69, 1995.