Effects of the antiestrogen, RU 58668, on female sexual behavior in rats

Brain Research Bulletin

Volumn 41, Issue 2, 1996, Pages 121-124

  Vagell, Michael E ^a   McGinnis, Marilyn Y ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Antagonist; Body weight; Estrogen receptor; Feeding; Lordosis; Proceptivity

Indexed keywords

11 [4 [[5 [(4,4,5,5,5 PENTAFLUOROPENTYL)SULFONYL]PENTYL]OXY]PHENYL]ESTRADIOL; ANTIESTROGEN; ESTROGEN RECEPTOR; NITROMIFENE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; BREAST CANCER; CONTROLLED STUDY; DRUG EFFECT; FEEDING BEHAVIOR; FEMALE; LORDOSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SEXUAL BEHAVIOR;

EID: 0029815142     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(96)00158-X     Document Type: Article

References (35)

1. 1. Ahdieh, H. B.; Wade, G. N. Effects of hysterectomy on sexual receptivity, food intake, running wheel activity, and hypothalamic estrogen and progestin receptors in rats. J. Comp. Physiol. Psychol. 96:886-892; 1982.
2. 2. Arai, Y.; Gorski, R. A. Effect of anti-estrogen on steroid induced sexual receptivity in ovariectomized rats. Physiol. Behav. 3:351-353; 1968.
3. 3. Baum, M. J.; Everitt, B. J.; Herbert, J.; Keverne, E. B. Hormonal basis of proceptivity and receptivity in female primates. Arch. Sex Behav. 6:173-192; 1977
4. 4. Baum, M. J.; Vreeburg, J. T. Differential effects of the anti-estrogen MER-25 and of three 5 alpha-reduced androgens on mounting and lordosis behavior in the rat. Horm. Behav. 7:87-104; 1976.
5. 5. Beach, F. A. Sexual attractivity, proceptivity, and receptivity in female mammals. Horm. Behav. 7:105-138; 1976.
6. 6. Blaustein, J. D.; Dudley, S. D.; Gray, J. M.; Roy, E. J.; Wade, G. N. Long-term retention of estradiol by brain cell nuclei and female rat sexual behavior. Brain Res. 173:355-359; 1979.
7. 7. Clark, R. G.; Tarttelin, M. F. Some effects of ovariectomy and estrogen replacement on body composition in the rat. Physiol. Behav. 28:963-969; 1982.
8. 8. Devenport, L.; Torres, A. Aldosterone-stimulated feeding and weight gain: Interactions with estrogen? Physiol. Behav. 33:745-749; 1984.
9. 9. Dudley, S. D. Responsiveness to estradiol in central nervous system of aging female rats. Neurosci. Biobehav. Rev. 6:39-45; 1982.
10. 10. Erskine, M. S. Solicitation behavior in the estrous female rat: A review. Horm. Behav. 23:473-502; 1989.
11. 11. Hedden, A.; Muller, V.; Jensen, E. V. A new interpretation of antiestrogen action. Ann. NY Acad. Sci. 761:109-120; 1995.
12. 12. Jordan, C. V. Biochemical pharmacology of antiestrogen action. Pharmacol. Rev. 36:245-276; 1984.
13. 13. Krey, L. C.; McGinnis, M. Y. Time-courses of the appearance/disappearance of nuclear androgen + receptor complexes in the brain and adenohypophysis following testosterone administration/withdrawal to castrated male rats: Relationships with gonadotropin secretion. J. Steroid Biochem. 35:403-408; 1990.
14. 14. Lerner, L. J.; Holthaus, F. J.; Thompson, C. R. A nonsteroidal estrogen antagonist 1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol. Endocrinology 63:295-318; 1958.
15. 15. McGinnis, M. Y.; Krey, L. C.; MacLusky, N. J.; McEwen, B. S. Steroid receptor levels in intact and ovariectomized estrogen-treated rats: An examination of quantitative, temporal and endocrine factors influencing the efficacy of an estradiol stimulus. Neuroendocrinology 33:158-165; 1981.
16. 16. Meisel, R. L.; Dohanich, G. P.; McEwen, B. S.; Pfaff, D. W. Antagonism of sexual behavior in female rats by ventromedial hypothalamic implants of antiestrogen. Neuroendocrinology 45:201-207; 1987.
17. 17. Montagne, M. N.; Dussaillant, M.; Chew, L. J.; Berod, A.; Lamberts, S. J.; Carter, D. A.; Rostene, W. Estradiol induces vasoactive intestinal peptide and prolactin gene expression in the rat anterior pituitary independently of plasma prolactin levels. J. Neuroendocrinol. 7:225-231; 1995.
18. 18. Morali, G.; Beyer, C. Neuroendocrine control of mammalian estrous behavior. In: Beyer, C., ed. Endocrine control of sexual behavior. New York: Raven Press; 1979:33-75.
19. 19. Morin, L. P.; Powers, J. B.; White, M. Effects of the antiestrogens, MER-25 and CI-628, on rat and hamster lordosis. Horm. Behav. 7:283-291; 1976.
20. 20. Nique, F.; Van de Velde, P. RU 58668, antineoplastic pure antiestrogen. Drugs Future 20:362-366; 1995.
21. 21. Roy, E. J.; Maass, C. A.; Wade, G. N. Central action and a species comparison of the estrogenic effects of an antiestrogen on eating and body weight. Physiol. Behav. 18:137-140; 1977.
22. 22. Roy, E. J.; Wade, G. N. Estrogenic effects of an antiestrogen, MER-25, on eating and body weight in rats. J. Comp. Physiol. Psychol. 90:156-166; 1976.
23. 3H] estradiol by brain cell nuclei and female rat sexual behavior: Inhibition by antiestrogens. Brain Res. 126:73-87; 1977.
24. 24. Siegel, H. I.; Cohen, P.; Rosenblatt, J. S. The effect of hysterectomy on hormone-induced lordosis behavior in hamsters. Physiol. Behav. 23:851-853; 1979.
25. 25. Thomas, E. J.; Walton, P. L.; Thomas, N. M.; Dowsett, M. The effects of ICI 182,780, a pure anti-oestrogen, on the hypothalamic-pituitary-gonadal axis and on endometrial proliferation in premenopausal women. Hum. Reprod. 9:1991-1996; 1994.
26. 26. Van de Velde, P.; Nique, F.; Bouchoux, F.; Bremaud, J.; Hameau, M. C.; Lucas, D.; Moratille, C.; Viet, S.; Philibert, D.; Teutsch, G. RU 58,668, a new pure antiestrogen inducing a regression of human mammary carcinoma implanted in nude mice. J. Steroid Biochem. Mol. Biol. 48:187-196; 1994.
27. 27. Van de Velde, P.; Nique, F.; Bremaud, J.; Hameau, M. C.; Philibert, D.; Teutsch, G. Exploration of the therapeutic potential of the antiestrogen RU 58668 in breast cancer treatment. Ann. NY Acad. Sci. 761:164-175; 1995.
28. 28. Wade, G. N. Sex hormones, regulatory behaviors and body weight. In: Rosenblatt, J. S.; Hindle, R. A.; Shaw, E. Beer, C. G., eds. Advances in the study of behavior, vol. 6. New York: Academic Press; 1976:201.
29. 29. Wade, G. N. Blaustein, J. D. Effects of an antiestrogen on neural estradiol binding and on behaviors in female rats. Endocrinology 102:245-251; 1978.
30. 30. Wade, G. N.; Blaustein, J. D.; Gray, J. M.; Meredith, J. M. ICI 182,780: A pure antiestrogen that effects behaviors and energy balance in rats without acting on the brain. Am. J. Physiol. 265:R1392-1398; 1993.
31. 31. Wade, G. N.; Heller, H. W. Tamoxifen mimics the effects of estradiol on food intake, body weight, and body composition in rats. Am. J. Physiol. 264:R1219-1223; 1993.
32. 32. Wade, G. N.; Powers, J. B.; Blaustein, J. D.; Green, D. E. ICI 182,780 antagonizes the effects of estradiol on estrous behavior and energy balance in Syrian hamsters. Am. J. Physiol. 265:R1399-1403; 1993.
33. 33. Wade, G. N.; Zucker, I. Development of hormonal control over food intake and body weight in female rats. J. Comp. Physiol. Psychol. 70:213-220; 1970.
34. 34. Wakeling, A. E.; Bowler, J. Novel antiestrogens without partial agonist activity. J. Steroid Biochem. Mol. Biol. 31:645-653; 1988.
35. 35. Wakeling, A. E.; Bowler, J. ICI 182,780, a new antiestrogen with clinical potential. J. Steroid Biochem. Mol. Biol. 43:173-177; 1992.