Down-regulation of rat β-adrenoceptors by clenbuterol or desipramine does not require chronic treatment: [3H]CGP-12177 binding reveals rapid (24 hour) modulation

Brain Research Bulletin

Volumn 41, Issue 2, 1996, Pages 93-96

  Newman Tancredi, A ^a   Verriele L ^a   Chaput, C ^a   Millan, M J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Acute treatment; Clenbuterol; Desipramine; Down regulation; 3H CGP 12177; Adrenoceptor

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; AMITRIPTYLINE; BIOCHEMICAL MARKER; CLENBUTEROL; CLORGYLINE; DESIPRAMINE; FLUOXETINE; MAPROTILINE; NOMIFENSINE; RECEPTOR SUBTYPE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGENIC MODULATION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; ELECTROCONVULSIVE THERAPY; INTRAPERITONEAL DRUG ADMINISTRATION; LONG TERM CARE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION;

EID: 0029815088     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(96)00150-5     Document Type: Article

References (15)

1. 1. Aulakh, C. S.; Cohen, R. M.; Dauphin, M. M.; McLellan, C. A.; Murphy, D. L. Role of serotoninergic input on the down-regulation of β-adrenoceptors following long-term clorgyline treatment. Eur. J. Pharmacol. 156:63-70; 1988.
2. 2. Barbaccia, M. L.; Ravizza, L.; Costa, E. Maprotiline: an antidepressant with unusual pharmacological profile. J. Pharmacol. Exp. Ther. 236:307-312; 1986.
3. 2-adrenoceptors. Br. J. Pharmacol. 92:827-834; 1987.
4. 4. Benfield, P.; Ward, A. Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drug 32:313-334; 1986.
5. 2 receptors and the abundancies of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain Res. 638:311-324; 1994.
6. 6. Finnegan, K. T.; Terwilliger, M. M.; Berger, P. A.; Hollister, L. E.; Csernansky, J. G. A comparison of the neurochemical and behavioural effects of clenbuterol and desipramine. Eur. J. Pharmacol. 134:131-136; 1987.
7. 2-adrenoceptors in rat cortex. J. Neurochem 53:1019-1025; 1989.
8. 8. Hyttel, J.; Overo, K. F.; Arnt, J. Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram. Psychopharmacol. 83:20-27; 1984.
9. 2-adrenoceptors in rat brain. Life Sci. 47:1683-1691; 1990.
10. 10. Ozawa, H.; Katamura, Y.; Hatta, S.; Amemiya, N.; Saito, T.; Ohshika, H.; Takahata, N. Antidepressants directly influence in situ binding of guanine nucleotide in synaptic membrane. Life Sci. 54:925-932; 1994.
11. 2 receptors after antidepressant administration in the forced swim test and after chronic antidepressant drug treatment. J. Pharmacol. Exp. Ther. 246:956-962; 1988.
12. 12. Racagni, G.; Brunello, N. Transynaptic mechanisms in the action of antidepressant drugs. TiPS 12:527-531; 1984.
13. 3H]dihydroalprenolol. Mol. Pharmacol. 36:201-210; 1989.
14. 14. Riva, M. A.; Creese I. Reevaluation of the regulation of β-adrenergic receptor binding by desipramine treatment. Mol. Pharmacol. 36:211-218; 1989.
15. 15. Willner, P. The ability of antidepressant drugs to desensitise β-receptors is inversely correlated with their clinical potency. J. Affective Disorders 7:53-58; 1984.