Plasminogen modulation of IL-1-stimulated degradation in bovine and human articular cartilage explants. The role of the endogenous inhibitors: PAI-1, α2-antiplasmin, α1-PI, α2-macroglobulin and TIMP

Inflammation Research

Volumn 45, Issue 9, 1996, Pages 464-472

  Oleksyszyn, J ^a   Augustine, A J ^a  

^a Dyax Corp   (United States)

Author keywords

Cartilage; Fibrinolytic cascade; Matrix metalloproteinases; Plasminogen; TIMP

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 2 ANTIPLASMIN; ALPHA 2 MACROGLOBULIN; COLLAGENASE; INTERLEUKIN 1; METALLOPROTEINASE; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE PROTEINASE INHIBITOR; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ARTHROPATHY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; ISOTOPE LABELING; SYNOVIAL FLUID;

EID: 0029814913     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02252318     Document Type: Article

References (45)

1. Van den Berg WB, Van de Loo FAJ, Vanlent PL, Joosten LAB. Mechanism of cartilage destruction in joint inflammation. Agents Actions 1993; Suppl 39:49-60.
2. Pianon M, Punzi L, Stefani MP, Bertazzolo N, Michelotto M, Finco B, et al. Interleukin-1-beta, plasminogen activator and inhibitor of plasminogen activator in synovial fluid of rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Agents Actions 1994;41:88-9.
3. Xie D, Hui F, Meyers R, Homandberg GA. Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis. Arch Biochem Biophys 1994;311:205-12.
4. Woessner Jr JF. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991;5:2145-54.
5. Tiku ML, Liesch JB, Robertson FM. Production of hydrogen peroxide by rabbit articular chondrocytes. J Immunol 1990;145:690-6.
6. Lansinger O, Berman B, Anderson GBJ. Tibial condyle fractues - a twenty-year follow-up. J Bone Joint Surg 1986; 68A:13-9.
7. Vassalli JD, Sappino AP, Belin D. The plasminogen activator/ plasmin system. J Clin Invest 1991;88:167-72.
8. Kushner I, Somerville JA. Permeability of human synovial membrane to plasma proteins: relationship to molecular size and inflammation. Arthr Rheum 1971;14:560-70.
9. Kummer JA, Abbink JJ, deBoer JP, Roem D, Nieuwenhuys EJ, Kamp AM, et al. Analysis of intraarticular fibrinolytic pathways in patients with inflammatory and non-inflammatory joint diseases. Arthr Rheum 1992;35:884-93.
10. Campbell IK, Piccoli DS, Butler DM, Singleton DK, Hamilton JA. Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue and urokinase-type plasminogen activator. Biochim Biophys Acta 1988;967: 183-94.
11. Campbell IK, Wojta J, Novak U, Hamilton JA. Cytokine modulation of plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes. Down-regulation by tumour necrosis factor-A and up-regulation by transforming growth factor-B and basic fibroblast growth factor. Biochim Biophys Acta 1994;1226:277-85.
12. Steinberg J, Sledge CB, Noble J, Stirrat CRA. Tissue culture model of cartilage breakdown in rheumatoid arthritis. Biochem J 1979;180:403-12.
13. Morales T. Articular cartilage organ cultures. In vitro models of matrix homeostasis, resorption, or repair. In: Woessner Jr JF, Howell DS, editors. Joint Cartilage Degradation. New York, Basel, Hong Kong: Marcel Dekker, 1993:261-80.
14. Wright SW, Petraitis JJ, Abelman MM, Batt DG, Bostrom LL, Corbett RL, et al. Heteroaryl-fused 2-phenylisothiazolone inhibitors of cartilage breakdown. J Med Chem 1994;37:3071-8.
15. Collier S, Ghosh P. The role of plasminogen in interleukin-1-mediated cartilage degradation. J Rheumatol 1988;15:1129-37.
16. Gavrilovic J, Murphy G. The role of plasminogen in cell-mediated collagen degradation. Cell Biol Int Rep 1989;13:367-75.
17. Reife RA, Stuart JM, Hasty KA. Pathological cartilage degradation in human arthritides. In: Woessner Jr JF, Howell DS, editors. Joint Cartilage Degradation. New York. Basel, Hong Kong: Marcel Dekker, 1993:409-33.
18. Hall AC, Urban JPG, Gehl KA. The effect of hydrostatic pressure on matrix synthesis in articular cartilage. J Orthop Res 1991;9:1-10.
19. Neidel J, Zeidler U. Independent effects of interleukin-1 on proteoglycan synthesis and proteoglycan breakdown of bovine articular cartilage in vitro. Agents Actions 1993;39: 82-90.
20. Murphy G, Atkinson RW, Gavrilovic J, Reynolds JJ. The role of plasminogen activator in the regulation of connective tissue metalloproteinases. Ann NY Acad Sci 1992;667:1-12.
21. Burkhardt H, Schwingel M, Menninger H, Macartney HW, Tschesche H. Oxygen radicals as effectors of cartilage destruction. Arthr Rheum 1986;29:369-78.
22. Peppin GJ, Weiss SJ. Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils. Proc Natl Acad Sci USA 1986;83:4322-6.
23. Keski-Oja J, Lohi J, Tuuttila A, Tryggvason K, Vartio T. Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator. Exper Cell Res 1992; 202:471-6.
24. Mankhetkorn S, Abedinzadeh Z, Houee-Levin C. Antioxidant action of sodium diethyldithiocarbamate: reaction with hydrogen peroxide and superoxide radical. Free Rad Biol Med 1994;17:517-27.
25. Fukuda K, Dan H, Saitoh M, Takayama M, Tanaka S. Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage. Agents Actions 1994;42:71-3.
26. Cawston T, Plumpton T, Curry V, Ellis A, Powell L. Role of TIMP and MMP inhibition in preventing connective tissue breakdown. Ann NY Acad Sci 1994;723:75-83.
27. Sandy JD, Flannery CR, Neame PJ. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu373-Ala374 bond of the interglobular domain. J Clin Invest 1992;89:1512-6.
28. Buttle DJ, Saklatvala J, Tamai M, Barrett A. Inhibition of interleukin-1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases. Biochem J 1992;281:175-7.
29. Pelletier JP, Mineau F, Fraue MP, Martel-Pelletier J. Imbalance between the mechanism of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis. Arthr Rheum 1990;33:1466-76.
30. Dodge GR, Poole AR. Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilage and in explants of bovine articular cartilage cultured with interleukin-1. J Clin Invest 1989;83:647-61.
31. Dean DD, Martel-Pelletier J, Pelletier JP, Howell DS, Woessner Jr JF. Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage. J Clin Invest 1989;84:678-85.
32. Virca GD, Mallya RK, Pepys MB, Schnebli HP. Quantitation of human leukocyte elastase, cathepsin G, α-2-macroglobulin and α-1-proteinase inhibitor in osteoarthritic and rheumatoid arthritis synovial fluid. Adv Exp Med Biol 1984; 167:345-54.
33. 2-macroglobulin-proteinase complexes. Arthr Rheum 1984; 27:897-904.
34. Travis J, Salvesen GS. Human plasma proteinase inhibitors. Ann Rev Biochem 1983;52:655-709.
35. Tyagi SC, Simon SR. Role of disulfide exchange in α-1-protease inhibitor. Biochemistry 1992;31:10584-90.
36. Lawrence DA, Loskutoff DJ. Inactivation of plasminogen activator inhibitor by oxidants. Biochemistry 1986;25:6351-5.
37. Stief TW, Aab A, Heimburger N. Oxidative inactivation of purified human α-2-antiplasmin, antirombin-III and C-1-inhibitor. Thromb Res 1988;49:581-9.
38. Mochan E, Keler T. Plasmin degradation of cartilage proteoglycan. Biochim Biophys Acta 1984;800:312-5.
39. Quigley JP, Gold LI, Schwimmer R, Sullivan LM. Limited cleavage of cellular fibronectin by plasminogen activator purified from transfomed cells. Proc Natl Acad Sci USA 1987;84:2776-80.
40. Xie D, Hui F, Meyers R, Homandberg GA. Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis. Arch Biochem Biophys 1994;311:205-12.
41. Lust G, Burton Wurster N, editors. Fibronectin in osteoarthritis. Comparison of animal and human diseases. Articular Cartilage and Osteoarthritis. New York: Raven Press, 1992: 447-54.
42. Butler M, Colombo C, Hickman L, O'Byrne E, Steele R, Steinetz B, et al. A new model of osteoarthritis in rabbits. Arthr Rheum 1983;26:1380-6.
43. Stevens P, Scott RW, Shatzen EM. Recombinant human protease nexin-1 prevents articular cartilage degradation in the rabbit. Agents Actions Suppl 1993;39:173-7.
44. Matsuo O, Tanaka S, Kikuchi H. Effect of urinary trypsin inhibitor on osteoarthritis. Thromb Res 1988;52:237-45.
45. Henrotin Y, Deby-Dupont G, Deby C, Pincemail J, Franchimont P. Active oxygen species production and vitamin-E levels in human articular chondrocytes. Free Radical Res. Commun. Volume of abstract from conference "Free radicals: from Basic Science to Medicine", Torino, Italy, June 16-20, 1992, Abstract #9.15, 1992.