Cloning of thrombopoietin and its therapeutic potential

Cancer Chemotherapy and Pharmacology, Supplement

Volumn 38, Issue , 1996, Pages

  Miyazaki, Hiroshi ^a  

^a KIRIN BREWERY CO LTD   (Japan)

Author keywords

CFU MK; Megakaryocyte; Platelet; Thrombocytopenia; Thrombopoietin

Indexed keywords

MITOMYCIN C; NIMUSTINE; RECOMBINANT THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; MALE; MEGAKARYOCYTE; MOLECULAR CLONING; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE; THROMBOCYTOPENIA;

EID: 0029814620     PISSN: 09439404     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800051043     Document Type: Conference Paper

References (22)

1. Banu N, Wang J, Deng B, Groopman JE, Avraham H (1995) Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand. Blood 86: 1331
2. Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobson R, Xie C, Shutter H, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MC-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA (1994) Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77: 1117
3. Born GVR (1962) Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 194: 927
4. Broudy VC, Lin NL, Kaushansky K (1995) Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85: 1719
5. Debili N, Wendling F, Cosman D, Titeux M, Florindo C, Dusanter-Fourt I, Schooley K, Methia N, Charon M, Nador R, Bettaieb A, Vainchenker W (1995) The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 85: 391
6. De Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL (1994) Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369: 533
7. Farese AM, Hunt P, Boone T, MacVittie TJ (1995) Recombinant human megakaryocyte growth and development factor stimulates thrombopoiesis in normal nonhuman primates. Blood 86: 54
8. Hunt P, Li YS, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Hornkohl AC, Lu H, Clogston C, Merewether LA, Johnson MJ, Parker V, Knudten A, Farese A, Hsu RY, Garcia A, Stead R, Bosselman RA, Bartley TD (1995) Purification and biological characterization of plasma-derived megakaryocyte growth and development factor. Blood 86: 540
9. Kato T, Ogami K, Shimada Y, Iwamatsu A, Sohma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kobayashi K, Ohashi H, Ozawa T, Inoue H, Kawamura K, Miyazaki H (1995) Purification and characterization of thrombopoietin. J Biochem 118: 229
10. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC (1994) Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369: 568
11. Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C (1995) Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92: 3234
12. Kuter DJ, Beeler DL, Rosenberg RD (1994) The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91: 11104
13. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC (1994) Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369: 565
14. Miyazaki H, Inoue H, Yanagida M, Horie K, Mikayama T, Ohashi H, Nishikawa M, Suzuki T, Sudo T (1992) Purification of rat megakaryocyte colony-forming cells using a monoclonal antibody against rat platelet glycoprotein IIb/IIIa. Exp Hematol 20: 855
15. Miyazaki H, Horie K, Shimada Y, Kokubo A, Maeda E, Inoue H, Kato T (1995) A simple and quantitative liquid culture system to measure megakaryocyte growth using highly purified CFU-MK. Exp Hematol 23: 1224
16. Nichol JL, Hokom MM, Hornkohl A, Sheridan WP, Ohashi H, Kato T, Li YS, Bartley TD, Choi E, Bogenberger J, Skrine JD, Knudten A, Chen J, Trail G, Sleeman L, Cole S, Grampp G, Hunt P (1995) Megakaryocyte growth and development factor: analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 95: 2973
17. Ogami K, Shimada Y, Sohma Y, Akahori H, Kato T, Kawamura K, Miyazaki H (1995) The sequence of a rat cDNA encoding thrombopoietin. Gene 158: 309
18. Shimada Y, Kato T, Ogami K, Horie K, Kokubo A, Kudo Y, Maeda E, Sohma Y, Akahori H, Kawamura K, Miyazaki H (1995) Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. Exp Hematol 23: 1388
19. Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimada Y, Kawamura K, Miyazaki H (1994) Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 353: 57
20. Ulich TR, Castillo J del, Yin S, Swift S, Padilla D, Senaldi G, Bennett L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P (1995) Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86: 971
21. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W (1994) c-MPL ligand is a humoral regulator of megakaryocytopoiesis. Nature 369: 571
22. Zeigler FC, Sauvage F de, Widmer HR, Keller GA, Donahue C, Schreiber RD, Malloy B, Haas P, Eaton D, Mattews W (1994) In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84: 4045