Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: Possible role of in situ-generated reactive oxygen species

Carcinogenesis

Volumn 17, Issue 9, 1996, Pages 2023-2028

  Giri, Uma ^a   Iqbal, Mohammad ^a   Athar, Mohammad ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; DNA; PHOTOFRIN II; PORPHYRIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CARCINOGENESIS; CARCINOMA IN SITU; CONTROLLED STUDY; DNA SYNTHESIS; HISTOPATHOLOGY; LATENT PERIOD; MOUSE; NONHUMAN; PHOTODYNAMICS; PHOTOSENSITIZATION; PRIORITY JOURNAL; SKIN PAPILLOMA; SKIN TUMOR; TUMOR PROMOTION;

EID: 0029814520     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.9.2023     Document Type: Article

References (38)

1. Mukhtar, H., Merk, H.F. and Athar, M. (1989) Skin chemical carcinogenesis. Clinics Dermatol., 7, 1-10
2. Slaga, T.J. (1984) In Slaga T.J. (ed.), Mechanism of Tumor Promotion. CRC Press, Boca Raton, FL, Vol. 2, pp. 1-16
3. Troll, B.G. and Wiesner, R. (1985) The role of oxygen radicals as a possible mechanism of tumor promotion. Annu. Rev. Pharmacol. Toxicol., 25, 509-528.
4. Ames, B.N. (1983) Dietary carcinogenesis and anticarcinogenesis. Science, 224, 12656-12662.
5. Athar, M., Raza, H., Bickers, D.R. and Mukhtar, H. (1990) Inhibition of BPO-mediated tumor promotion in 7,12-dimethyl benz(a)anthracene initiated skin of Sencar mice by antioxidant NDGA and DAS. J. Invest. Dermatol., 94, 162-165.
6. Keisari, Y., Flescher, E. and Geva, I. (1984) Macrophage oxidative burst and related cytotoxicity, I. Differential activation by tumor promoting and non-tumor promoting phorbol esters. Int. J. Cancer, 34, 845-848.
7. Slaga, T.J., Kelin-Szanto, A.J.P., Triplet, L.L., Yotti, L.P. and Trosko, J.E. (1981) Skin tumor promoting activity of benzoyl peroxide, a widely used free radical generating compound. Science, 213, 1023-1025.
8. Logani, M.K., Sambuco, C.P., Forbes, P.D. and Davies, R.E. (1984) Skin tumor promoting activity of methyl ethyl ketone peroxide - a potent lipid-peroxidizing agent. Food Chem. Toxicol., 22, 879-882.
9. Sun, Y. (1990) Free radicals, antioxidant enzymes, and carcinogenesis. Free Radical Biol. Med., 8, 583-599.
10. Wei, H. and Frenkel, K. (1993) Relationship of oxidative events and DNA oxidation in Sencar mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis, 14, 1195-1201.
11. Athar, M., Mukhtar, H., Bickers, D.R., Khan, I.U. and Kalyanaraman, B. (1989) Evidence for the metabolism of tumor promotor organic hydroperoxides into free radicals by human skin keratinocytes. An ESR spin trapping study. Carcinogenesis, 10, 1499-1503.
12. Timmins, G.S. and Davies, M.J. (1993) Free radical formation in isolated murine keratinocytes treated with organic peroxides and its modulation by antioxidants. Carcinogenesis, 14, 1615-1620.
13. Taffe, B.G., Takahashi, N., Kensler, T.W. and Mason, R.P. (1987) Generation of free radicals from organic hydroperoxide tumor promoters in isolated mouse keratinocytes. J. Biol. Chem., 262, 12143-12149.
14. Zimmerman, R. and Cerutti, P. (1984) Active oxygen acts as promoter of transformation in mouse C3H/10T1/2C18 fibroblasts. Proc. Natl Acad. Sci. USA, 81, 2085-2087.
15. Giri, U., Sharma, S.D., Abdulla, M. and Athar, M. (1995) Evidence that in situ generated reactive oxygen species act as potent stage-I tumor promoter in mouse skin. Biochem. Biophys. Res. Commun., 209, 698-705.
16. Lipson, R.L., Baldes, A.M. and Olson, A.M. (1961) The use of a derivative of hematoporphyrin in tumor detection. J. Natl Cancer Inst., 26, 1-8.
17. Dougherty, T.J., Lawrence, G., Kaufman, J.H., Boyle, D., Weishaupt, K.R. and Goldfarb, A. (1979) Photoradiation in the treatment of recurrent breast carcinoma. J. Natl Cancer Inst., 62, 231-237.
18. Elmets, C.A., Lewen, R.L., Khan, W.A., Mukhtar, H. and Bickers, D.R. (1987) Photofrin-II photodynamic therapy: pharmacokinetics and efficacy in the treatment of chemically induced skin tumors in mice. Photochem. Photobiol., 45, 1035.
19. Athar, M., Elmets, C.A., Bickers, D.R. and Mukhtar, H. (1989) A novel mechanism for the generation of Superoxide anions in hematoporphyrin derivative-mediated cutaneous photosensitization. Activation of the xanthine oxidase pathway. J. Clin. Invest., 83, 1137-1143.
20. Mukhtar, H., Agarwal, R., Athar, M., Lewen, R., Elmets, C.A. and Bickers, D.R. (1991) Photodynamic therapy of murine skin tumors using Photofrin-II. Photodermatol. Photoimmunol. Photomed., 8, 169-175.
21. Athar, M., Lloyd, J.R., Bickers, D.R. and Mukhtar, H. (1989) Malignant conversion of UV radiation and chemically induced mouse skin benign tumors by free radical generating compounds. Carcinogenesis, 10, 1841-1845.
22. O'Connell, J.F., Klein-Szanto, A.P.J., DiGiovanni, D.M., Fries, J.W. and Slaga, T.J. (1986) Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res., 46, 2863-2865.
23. O'Brien, T.G., Simsiman, R.C. and Boutwell, R.K. (1975) Induction of polyamine biosynthetic enzymes in mouse epidermis by tumor promoting agents. Cancer Res., 35, 1662-1670.
24. Verma, A.K., Shapas, B.G., Rice, H.M. and Boutwell, R.K. (1979) Correlation of the inhibition by retinoid of tumor promotor-induced mouse epidermal ornithine decarboxylase activity and skin tumor promotion. Cancer Res., 39, 419-425.
25. Smart, R.C., Huang, M.T. and Conney, A.H. (1986) sn-1,2-Diacyl-glycerol mimics the effects of TPA in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis. Carcinogenesis, 7, 1865-1870.
26. Athar, M., Mukhtar, H., Elmets, C.A., Zaim, M.T., Lloyd, J.R. and Bickers, D.R. (1988) In situ evidence for the involvement of Superoxide anions in cutaneous porphyrin photosensitization. Biochem. Biophys. Res. Commun., 151, 1054-1059.
27. Athar, M., Mukhtar, H. and Bickers, D.R. (1988) Differential role of reactive oxygen intermediates in photofrin-I and photofrin-II-mediated photoenhancement of lipid peroxidation in epidermal microsomal membranes. J. Invest. Dermatol., 90, 652-657.
28. Krutmann, J., Athar, M., Mendel, D.B., Khan, I.U., Guyre, P.M., Mukhtar, H. and Elmets, C.A. (1989) Inhibition of the high affinity Fc receptor (FcΓR1) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals. J. Biol. Chem., 264, 11407-11413.
29. Kensler, T.M. and Taffe, B.G. (1986) Free radicals in tumor promotion. Adv. Free Radical Biol. Med., 2, 347-387.
30. Birnboim, H. (1982) DNA strand breakage in human leukocyte exposed to a tumor promoter, phorbol-myristate-acetate. Science, 215, 1247-1249.
31. Muehematter, D., Larson, R. and Cerutti, P. (1988) Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non promotable JB6 mouse epidermal cells. Carcinogenesis, 9, 239-245.
32. Emerit, I. and Cerutti, P. (1981) Tumor promoter phorbol-12-myristate-13 acetate induces chromosomal damage via indirect action. Nature, 293, 144-146.
33. Dzarliieva, R. and Fusenig, N. (1982) Tumor promoter 12-O-tetradecanoylphorbol-13-acetate enhances sister chromatid exchanges and numerical and structural chromosomal aberration in primary mouse epidermal culture. Cancer Lett., 16, 7-17.
34. Weitzman, S.A. and Stossel, T.P. (1981) Mutation caused by human phagocytes. Science, 212, 546-547.
35. Weitzman, S., Weitberg, A., Clark, E. and Stossel, T. (1985) Phagocytes as carcinogens: malignant transformation produced by human neutrophils. Science, 227, 1231-1233.
36. Leadon, S.A. (1987) Production of thymine glycols in DNA by radiation and chemical carcinogens as detected by a monoclonal antibody. Br. J. Cancer. 8 (Suppl.), 113-117.
37. Amstad, P. and Cerutti, P. (1990) Genetic modulation of the cellular antioxidant defence capacity. Environ. Hlth Perspect., 88, 77-82.
38. Luna, M.C., Wong, S. and Gomer, C.J. (1994) Photodynamic therapy mediated induction of early response genes. Cancer Res., 54, 1374-1380.