Effects of Parathyroid Hormone on Hepatocyte pHi and Na+-H+ Exchanger Activity

American Journal of Nephrology

Volumn 16, Issue 5, 1996, Pages 431-441

  Michnowska, Maria ^a   Smogorzewski, Miroslaw ^a   Klin, Mariusz ^a   Sahai, Atul ^a   Massry, Shaul G ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Hepatocytes; Intracellular pH; Na+ H+ exchanger activity; Parathyroid hormone

Indexed keywords

AMILORIDE; BUCLADESINE; CALCIUM ION; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NIFEDIPINE; PARATHYROID HORMONE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; STAUROSPORINE; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL PH; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT;

AMMONIA; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; LIVER; MALE; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER;

EID: 0029814489     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000169037     Document Type: Article

References (36)

1. 2+], and intracellular pH in lymphocytes. J Gen Phvsiol 1957;89:185-213.
2. Muldoon LL, Dinerstein RJ, Villereal ML: Intracellular pH in human fibroblasts: Effect of mitogens. A 23187, and phospholipase activation. Am J Physiol 1985:249:040-048.
3. + exchange in rat parotid acinar cells is dependent on calcium but not on protein kinase-C. J Biol Chem 1950:265:4284-4289.
4. + antiporter. J Membr Biol 1989:108:207-215.
5. Massry SG, Smogorzcski M: The mechanisms responsible for the PTH-induced rise in cytosolic calcium in various cells are not uniform. Miner Electrolyte Metab 1995;21:13-28.
6. + exchange in renal brush border vesicles. Am J Phvsiol 1985; 248:F212-F218.
7. + exchange in opossum kidney cells by parathyroid hormone, cyclic AMP. and phorbol esters. Plliigcrs Arch 1990; 415:461-470.
8. Pollack AS, Warnock DG, Strewler GJ: Parathyroid hormone inhibition of Na'-H' anti-porter activity in a cultured renal cell line. Am J Physiol 1986;250:F217-F225.
9. Sasaki S, Marumo F: Mcchanismsofinhibition of proximal acidification by PTH. Am J Physiol 1991 ;260:F833-F838.
10. Cooper RH, Coll KE, Williamson JR: Differential effects of phorbol ester on pheny lephrine and vasopressin-induced calcium mobilization in isolated hepatocytes. J Biol Chem 1976:357: 1477-1486.
11. Klin M, Smogorzewski M, Khilnani H, Mich-nowska M, Massry SG: Mechanisms of PTH-induced rise in cytosolic calcium in adult rat hepatocytes. Am J Phvsiol 1994:267:0754-763.
12. 2' entry in hepatocytes. Biochem J 1992; 289:243-247.
13. Anwer MS, Atkinson JM: Intracellular calcium-mediated activation of hepatic Na'-H* exchange by arginine vasopressin and phenylephrine. Hepatologv 1992:15:134-143.
14. Anwer MS: Mechanism of ionomycin-induced intracellular alkalinization of rat hepatocytes. Hepatology 1993:18:433-439.
15. Seglen PO: Preparation of isolated rat liver cells. Methods Cell Biol 1975:13:29-83.
16. Grinstein S, Cohen S, Goetz-Smilh JD, Dixon SJ: Measurement of cytoplasmic pH and cellular volume for detection of Na'-H' exchange in lymphocytes. Methods Enzymol 1989:173: 777-790.
17. Ross A, Boron WF: Intracellular pH. Physiol Rev 1981:61:296-434.
18. Sahai A, Langhrey F, Tannen RL: Relationship between intracellular pH and ammonia metabolism in LLC-PK1 cells. Am J Physiol 1990; 258:F103-F108.
19. Bradford M: A rapid sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976:72:248-254.
20. Meier PJ, Kickelbem R, Moseley RH, Dobbins JW, Bover JL: Evidence for carrier mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane. J Clin Invest 1985: 75:1256-1263.
21. Chijva TA, Mishima A, Hagiware M, Sano M, Havashi K, Inoue T, Naito K, Toshioka T, Hidale H: Inhibition of forskolin induced neu-ritc outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase. N-[2-(p-bro-mocinnanylamino)ethvl_]-5-isoquinolinesulfon-amide (H-89), of PCI 2D pheochromocytoma. J Biol Chem 1990;265:5267-5272.
22. Stewart DJ: Monitoring of sodium proton exchange in isolated hepatocytes by electronic cell sizing. Hepatology 1989:10:986-994.
23. + antiport bv AVP, PTH, and PGEi in rat medullary thick ascending limb cells. Am J Physiol 1993;264:F354-F364.
24. Green J, Kleeman CR: Role of calcium and cAMP messenger systems in intracellular pH regulation of oesteoblastic cells. Am J Phvsiol 1992;262:C111-C121.
25. + exchanger by arginine vasopressin in hepa-tocytcs. Hepatology 1994;20:1309-1317.
26. + exchange in isolated rat hepatocytes. Eur J Biochem 1989;87:677-682.
27. Stewart DJ: Sodium-proton exchanger in isolated hepatocytes exhibits a set point. Am J Physiol 1989;256:G44-G52.
28. + exchanger in human fibroblasts. J Biol Chem 1989:264: 19540-19547.
29. 2+, and amiloride. J Cell Physiol 1981;107:359-369.
30. Orlowski J, Kandasomy RA, Shull GE: Molecular cloning of putative member of Na'/H' exchanger gene family. J Biol Chem 1992:267: 9331-9339.
31. + exchanger isoform 1 (NHE I) is a novel member of the calmodulin-binding proteins. J Biol Chem 1994:269:13703-13709.
32. 2+ regulation defective. J Biol Chem 1994:269:13710-13715.
33. 2+/calmodulin-depen-dent protein kinase II. Biochem 1992:282:139-145.
34. Sage SO, Jobson TM, Rink TJ: Agonist-evoked changes in cytosolic pH and calcium concentration :n human platelets: Studies in physiological bicarbonate. J Physiol (Lond) 1990:420:31-45.
35. Zavoico GB, Cragoe EJ Jr, Feinstein MB: Regulation of intracellular pH inhuman platelets. J Biol Chem 1986;261:13160-13167.
36. Massry SG, Coburn JW, Peacock M, Kleeman CR: Turnover of endogeneous parathyroid hormone in uremic patients and with those undergoing hemodialysis. Trans Am SocArtif Intern Organs 1972;18:416-422.