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Volumn 118, Issue 34, 1996, Pages 8142-8143

RNA photolabeling mechanistic studies: X-ray crystal structure of the photoproduct formed between 4-thiothymidine and adenosine upon near UV irradiation

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; PHOTOCHEMISTRY; RNA SYNTHESIS; ULTRAVIOLET IRRADIATION;

EID: 0029814112     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja961329g     Document Type: Article
Times cited : (21)

References (42)
  • 17
    • 9544250696 scopus 로고    scopus 로고
    • Unpublished results
    • Saintomé, C. Unpublished results.
    • Saintomé, C.1
  • 26
    • 9544232865 scopus 로고    scopus 로고
    • note
    • 1H NMR spectrum of the crude irradiated mixture.
  • 27
    • 9544258583 scopus 로고    scopus 로고
    • note
    • Purification was achieved on a medium-pressure (400 mhar) RP 18 column using a gradient of acetonitrile in water. Nucleosides 1 and 2 were recovered in 24% and 33% yield, respectively.
  • 28
    • 9544234813 scopus 로고    scopus 로고
    • note
    • 13C NMR chemical shifts of the aglycon nuclei are almost identical to those of 3.
  • 29
    • 9544246144 scopus 로고    scopus 로고
    • Attributed from the HMBC spectrum
    • Attributed from the HMBC spectrum.
  • 32
    • 9544235489 scopus 로고    scopus 로고
    • note
    • Purification was performed by HPLC on a semipreparative NOVA-PAK C18, 6μ radial pak cartridge, using a gradient of acetonitrile in 0.05 M sodium acetate.
  • 34
    • 9544225383 scopus 로고    scopus 로고
    • note
    • w= 0.086, goodness of fit 1.04, number of observed reflexions 1945.
  • 39
    • 84981860904 scopus 로고
    • The preferred N7-C8 imidazole ring fission of adenosine leading to a an W-9-formyl derivative is probably governed by the electron deficient nature of the N-7-substituent. This is inferred from analogous ring opening of 9-alkylated adenines undergoing N-7-acylation (Altman, J.; Ben-Ishai, D. J. Heterocycl. Chem. 1968, 5, 679-682. Leonard, N. J.; McDonald, J. J.; Henderson, R. E. L.; Reichmann, M. E. Biochemistry 1971, 10, 3335-3342).
    • (1968) J. Heterocycl. Chem. , vol.5 , pp. 679-682
    • Altman, J.1    Ben-Ishai, D.2
  • 40
    • 0015247071 scopus 로고
    • The preferred N7-C8 imidazole ring fission of adenosine leading to a an W-9-formyl derivative is probably governed by the electron deficient nature of the N-7-substituent. This is inferred from analogous ring opening of 9-alkylated adenines undergoing N-7-acylation (Altman, J.; Ben-Ishai, D. J. Heterocycl. Chem. 1968, 5, 679-682. Leonard, N. J.; McDonald, J. J.; Henderson, R. E. L.; Reichmann, M. E. Biochemistry 1971, 10, 3335-3342).
    • (1971) Biochemistry , vol.10 , pp. 3335-3342
    • Leonard, N.J.1    McDonald, J.J.2    Henderson, R.E.L.3    Reichmann, M.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.