The female brain hypoestrogenic continuum from the premenstrual syndrome to menopause: A hypothesis and review of supporting data

Journal of Reproductive Medicine for the Obstetrician and Gynecologist

Volumn 41, Issue 9, 1996, Pages 633-639

  Arpels, John C ^a  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

estrogens; menopause; perimenopause; premenstrual syndrome; progestins

Indexed keywords

ESTROGEN;

AMNESIA; ANXIETY NEUROSIS; BRAIN LEVEL; COGNITIVE DEFECT; ESTROGEN DEFICIENCY; FEMALE; HUMAN; IRRITABILITY; MENOPAUSE; NEUROENDOCRINOLOGY; PANIC; PREMENSTRUAL SYNDROME; PRIORITY JOURNAL; PUERPERAL DEPRESSION; REVIEW; SLEEP DISORDER;

ADULT; BRAIN CHEMISTRY; DEPRESSIVE DISORDER; ESTROGENS; FEMALE; HUMANS; MENOPAUSE; MIDDLE AGED; PREMENSTRUAL SYNDROME; PUERPERAL DISORDERS;

EID: 0029813566     PISSN: 00247758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (87)

1. Oldenhave A, Jaszmann LJ, Haspels AA, et al. Impact of climacteric on well-being: A survey based on 5213 women 39 to 60 years old. Am J Obstet Gynecol 1993;168:765-771
2. Asso D, Magos A: Psychological and physiological changes in severe premenstrual syndrome. Biol Psychol 1992;33: 115-132
3. Kendell RE, Wainwright S, Hailedy A, et al: The influence of childbirth on psychiatric morbidity. Psychol Med 1976;6: 297-302
4. Moos RH: Psychological aspects of oral contraceptives. Arch Gen Psychiatr 1968;19:87-94
5. Sherwin BB, Gelfand MM: A prospective one-year study of estrogen and progestin in postmenopausal women: Effects on clinical symptoms and lipoprotein lipids. Obstet Gynecol 1989;73:759-766
6. Sherwin BB: The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab 1991;72:336-343
7. McNaughton J, Bangah M, McCloud P, et al: Age-related changes in follicle-stimulating hormone, luteinizing hormone, oestradiol and immunoreactive inhibin in women of reproductive age. Clin Endocrinol 1992;36:339-345
8. Buckler HM, Anderson DC: The perimenopausal state and incipient ovarian failure. In Treatment of the Postmenopausal Woman: Basic and Clinical Aspects. Edited by RA Lobo. New York, Raven Press Limited, 1994, pp 11-23
9. Hunter M: The South-East England longitudinal study of the climacteric and postmenopause. Maturitas 1992;14:117-126
10. Casper RF, Graves GR, Reid RL: Objective measurement of hot flushes associated with the premenstrual syndrome. Fertil Steril 1987;47:341-344
11. Magos AL, Brewster E, Singh R, et al: The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: A model for the premenstrual syndrome. Br J Obstet Gynaecol 1986;93:1290-1296
12. Hammarbäck S, Bäckshöm T, Holst J, et al: Cyclic mood changes as in the premenstrual tension syndrome during sequential estrogen-progestagen postmenopausal replacement therapy. Acta Obstet Gynecol Scand 1985;64:393-397
13. Benz DJ, Haussler MR, Komm BS: Estrogen binding and estrogenic responses in normal human osteoblastic-like cells. J Bone Miner Res 1991;6:531-541
14. Ähraens L: The effects of estradiol on blood lipids and lipoproteins in postmenopausal women. Obstet Gynecol 1988;72:18s-22s
15. Sarrel PM: Ovarian hormones and the circulation. Maturitas 1990;12:287-298
16. Bush TL, Barrett-Connor E, Cowan LD, et al: Cardiovascular mortality and noncontraceptive use of oestrogen in women: Results from the Lipid Research Clinics Program Follow-up Study. Circulation 1987;75:1102-1109
17. Rauce NE: Hormonal influences on morphology and neuropeptide gene expression in the infundibular nucleus of postmenopausal women. Progr Brain Res 1992;93:221-235
18. Jensen J, Christiansen C: Dose-response and withdrawal effects on climacteric symptoms after hormonal replacement therapy: A placebo-controlled therapeutic trial. Maturitas 1983;5:125-133
19. Schiff I, Regestein Q, Schinfeld J, et al: Interactions of oestrogens and hours of sleep on cortisol, FSH, LH, and prolactin in hypogonadal women. Maturitas 1980;2:179-183
20. Best NR, Rees MP, Barlow DH, et al: Effects of estradiol implant on noradrenergic function and mood in menopausal subjects. Psychoneuroendocrinology 1992;17:87-93
21. Philipps SM, Sherwin BB: Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 1992;17:485-495
22. Barrett-Connor E, Kritz-Silverstein D: Estrogen replacement therapy and cognitive functions in older women. JAMA 1993;269:2637-2641
23. Riecher-Rössler A, Häfner H: Schizophrenia and oestrogens: Is there an association? Eur Arch Psychiatr Clin Neurosci 1993;242:323-328
24. Funk JL, Mortel KF, Meyer JS: Effects of estrogen replacement therapy on cerebral perfusion and cognition among postmenopausal women. Dementia 1991;2:268-272
25. Paganini-Hill A, Henderson VW: Estrogen deficiency and risk of Alzheimer's disease in elderly women. Am J Epidemiol 1994;140:256-261
26. McEwen BS: The brain as a target organ of endocrine hormones. In Neuroendocrinology. Edited by DT Kreiger, JC Hughes. Sunderland, Massachusetts, Sinauer Associates, 1980, pp 33-42
27. Frankfurt M, McEwen BS: Estrogen increases axodendritic synapses in the VMN of rats after ovariectomy. Neuroreport 1991;2:380-382
28. Leranth C, MacLusky NJ, Brown TJ, et al: Transmitter content and afferent connections of estrogen-sensitive progestin receptor-containing neurons in the primate hypothalamus. Neuroendocrinology 1992;55:667-682
29. Woolley CS, McEwen BS: Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Compar Neurol 1993; 336:293-306
30. Watson MA, Milbrandt J: The NGFI-β gene, a transcriptionally inducible member of the steroid receptor gene superfamily: Genomic structure and expression in rat brain after seizure induction. Mol Cell Biol 1989;9:4213-4219
31. Pfaff DW, McEwen BS: Actions of estrogens and progestins on nerve cells. Science 1983;219:808-814
32. McEwen BS, Bigeon A, Fischette CT, et al: Towards a neurochemical basis of steroid hormone action. In Frontiers in Neuroendocrinology. Edited by L Martini, W Ganong. New York, Raven Press, 1984 pp 1153-1176
33. D'Amico JF, Greendale GA, Lu JK, et al: Induction of hypothalamic opioid activity with transdermal estradiol administration in postmenopausal women. Fertil Steril 1991;55: 754-758
34. Morissette M, Lévesque D, Di Paolo T: Effect of chronic estradiol treatment on brain dopamine receptor reappearance after irreversable blockade: An autoradiographic study. Mol Pharmacol 1992;42:480-488
35. Gereau RW, Kedzie KA, Renner KJ: Effect of progesterone on serotonin turnover in rats primed with estrogen implants into the ventromedial hypothalamus. Brain Res Bull 1993;32: 293-300
36. Tomimatsu N, Hashimoto S, Akasofu K: Effects of oestrogen on hypothalamic β-endorphin in ovariectomized and old rats. Maturitas 1993;17:5-16
37. Guicheney P, Léger D, Barrat J, et al: Platelet serotonin content and plasma tryptophan in peri- and postmenopausal women: Variations with plasma oestrogen levels and depressive symptoms. Eur J Clin Invest 1988;18:297-304
38. Gonzales GF, Carillo C: Blood serotonin levels in postmenopausal women: Effects of age and serum oestradiol levels. Maturitas 1993;17:23-29
39. Luin VN, Khylcheoskaya RI, McEwen BS: Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain. Brain Res 1975;86:273-306
40. McEwen BS, Rhodes JC: Gonadal hormone regulation of MAO and other enzymes in hypothalamic areas. Neuroendocrinology 1983;36:235-238
41. Holzbauer M, Yondin MBH: The oestrous cycle and monoamine oxidase activity. Br J Pharmacol 1973;48:600-608
42. Schildkraut JJ: The catecholamine hypothesis of affective disorders: A review of supporting evidence. Am J Psychiatr 1965;122:509-522
43. Price WA, Giannini AJ. Antidepressant effects of estrogen. J Clin Psychiatr 1985;46:506-510
44. Speroff L, Glass RH, Kase NG: Clinical Gynecologic Endocrinology and Infertility. Baltimore, Williams & Wilkins, 1984, pp 30,34,35
45. Sherwin BB, Gelfand MM: Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. Am J Obstet Gynecol 1985;151:153-160
46. Collins P, Rosano GMC, Jiang C, et al: Cardiovascular protection by oestrogen: A calcium antagonist effect? Lancet 1993;341:1264-1265
47. Blackmore PF, Beebe SJ, Banforth DR, et al: Progesterone and 17 alpha-hydroxyprogesterone: Novel stimulators of calcium influx in human sperm. J Biol Chem 1990;265:1376-1380
48. Sarrel PM. Sexuality and menopause. Obstet Gynecol 1990; 75:265-325
49. Sarrel PM: Blood flow and ovarian secretions. In Ovarian Secretions and Cardiovascular and Neurovascular Function. Edited by F Naftolin, AH De Cherney, JN Gutmann, et al. Raven Press, 1990, pp 81-89
50. Sarrel PM: Personal communication, 1992
51. Ramirez VD, Dluzen D: Is progesterone a pre-hormone in the CNS? J Steroid Biochem 1987;27:589-598
52. Lam HY: Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase. Biochem Biophys Res Commun 1984;118:27-32
53. Ron IG, Inbar MJ, Barak Y, et al: Organic delusional syndrome associated with tamoxifen treatment. Cancer 1992;69: 1415-1417
54. Pardridge WM, Mietus LJ: Transport of steroid hormones through the rat blood brain barrier. J Clin Invest 1979;64: 145-154
55. Speroff L, Glass RH, Kase NG: Clinical Gynecologic Endocrinology and Infertility. Fifth edition. Baltimore, Williams and Witkins, 1994, p 59
56. Facchinetti F, Genazzani AD, Martignoni E, et al: Neuroendocrine changes in luteal function in patients with premenstrual syndrome. J Clin Endocrinol Metab 1993;76:1123-1127
57. Sherman BM, West JH, Korenman SG: The menopausal transition: Analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. JCE & M 1976;42:629-636
58. Hee J, MacNaughton J, Bangah M, et al: Perimenopausal patterns of gonadotrophins, immunoreactive inhibin, oestradiol and progesterone. Maturitas 1993;18:9-20
59. Bäckström T: Effects of natural and synthetic gestagens on mood and brain excitability. In The Modern Management of the Menopause. Edited by G Berg, M Hammar. New York, Parthenon Publishing Group, 1994, pp 295-299
60. Smith SS: Hormones, mood and neurobiology: A summary. In The Modern Management of the Menopause. Edited by G Berg, M Hammar. New York, Parthenon Publishing Group, 1994, pp 257-268
61. Robel P, Baulieu E-E: Neurosteroids, biosynthesis and function. TEM 1994;5:1-8
62. Schumacher M, Coirini H, McEwen BS: Regulation of GABAa receptors in specific brain regions by ovarian hormones. Neuroendocrinology 1989;50:315-320
63. Roberts E: Pregnenolone: From Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABAa receptor. Biochem Pharmacol 1995;49:1-16
64. Weiland NG: Estradiol selectivity regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus. Endocrinology 1992;131: 662-668
65. Pons M, Michel F, Descomps B, et al: Structural requirements for maximal inhibitory allosteric effect of estrogens and estrogen analogues on glutamate dehydrogenase. Eur J Biochem 1978;84:257-266
66. Smith SS: Activating effects of estradiol on brain activity. In The Modern Management of the Menopause. Edited by G Berg, M Hammar. New York, Parthenon Publishing Group, 1994, pp 279-294
67. Shideler SE, De Vane GW, Kalra PS, et al: Ovarian-pituitary hormone interactions during the perimenopause. Maturitas 1989;11:331-339
68. Umans RS, Weichselbaum RR, Johnson CM, et al: Effects of estradiol concentration on levels of nuclear estrogen receptors in MCF-7 breast tumor cells. J Steroid Biochem 1984; 20:605-609
69. Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: Relation to activation of the estrogen receptor. Pathol Biol (Paris) 1991;39:59-69
70. Desjardins GC, Brawer JR, Beaudet A: Estradiol is selectively neurotoxic to hypothalamic β-endorphin neurons. Endocrinology 1993;132:86-93
71. Gangar K, Cust M, Whitehead MI: Symptoms of oestrogen deficiency associated with supraphysiologic plasma oestradiol concentrations in women with oestradiol implants. Br Med J 1989;299:601-602
72. Thompson RF: Memory. Curr Opin Neurobiol 1992;2: 203-208
73. Von Cramon DY, Schuri U: The septo-hippocampal pathways and their relevance to human memory: A case report. Cortex 1992;28:411-422
74. Johnston AN, Rogers LJ, Johnston GA: Glutamate and imprinting memory: The role of glutamate receptors in the encoding of imprinting memory. Behav Brain Res 1993;54: 137-143
75. Lee EH, Lee CP, Wang HI, et al: Hippocampal CRF, NE, and NMDA system interactions in memory processing in the rat. Synapse 1993;14:144-153
76. Nordberg A: Biological markers and the cholinergic hypothesis in Alzheimer's disease. Acta Neurol Scand (suppl) 1992;130:54-58
77. Ohkura T, Isse K, Akazawa, et al: Evaluation of estrogen treatment in female patients with dementia of the Alzheimer type. Endocrinology J 1994;41:361-371
78. Ditkoff EC, Crary WG, Cristo M, et al: Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol 1991;78:991-995
79. Studd JWW, Smith RNJ: Estrogens and depression in women. Menopause J North Am Menopause Soc 1994;1: 33-37
80. Watson NR, Studd JW, Savvas M, et al: Treatment of severe premenstrual syndrome with estradiol patches and cyclic oral norethisterone. Lancet 1989;1:730-732
81. Watson NR, Studd JW, Savvas M, et al: The long-term effects of estradiol implant therapy for the treatment of premenstrual syndrome. Gynecol Endocrinol 1990;4:99-107
82. Smith RNJ, Studd JWW: Estrogens and depression in women. In Treatment of the Postmenopausal Woman: Basic and Clinical Aspects. Edited by RA Lobo. New York, Raven Press Limited, 1994, pp 129-136
83. Henderson AF, Gregoire AJP, Kumar RC, et al: Treatment of severe postnatal depression with oestradiol skin patches (lett). Lancet 1991;338:816-817
84. Maoz B, Shiber A, Lazer S, et al: The prevalence of psychological distress among postmenopausal women attending a menopausal clinic and the effect of hormone replacement therapy on their mental state. Menopause J North Am Menopause Soc 1994;1:137-141
85. Rahimy MH, Bodor N, Simpkins JW: Effects of a brainenhanced estrogen delivery system on tail-skin temperature of the rat: Implications for menopausal hot flush. Maturitas 1991;13:51-63
86. Henderson VW, Paganini-Hill A, Emanuel CK, et al: Estrogen replacement therapy in older women: Comparison between Alzheimer's disease cases and nondemented control subjects. Arch Neurol 1994;51:896-900
87. Smith RNJ, Holland EFN, Studd JWW: The symptomatology of progestogen intolerance. Maturitas 1994;18:87-91