Effect of in vivo administration of anesthetics on GABAA receptor function

Laboratory Animal Science

Volumn 46, Issue 4, 1996, Pages 425-429

  Engel, Sharon R ^a   Gaudet, Elizabeth A ^a   Jackson, Kathyjo A ^a   Allan, Andrea M ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BARBITURIC ACID; BENZODIAZEPINE; CARBON DIOXIDE; CHLORINE 36; FLUNITRAZEPAM; INHALATION ANESTHETIC AGENT; METHOXYFLURANE; PENTOBARBITAL;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CHLORIDE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GABAERGIC SYSTEM; INHALATION ANESTHESIA; INHALATIONAL DRUG ADMINISTRATION; MOUSE; NEUROPHARMACOLOGY; NEUROTRANSMISSION; NONHUMAN;

ANESTHESIA; ANESTHETICS; ANESTHETICS, INHALATION; ANIMALS; BRAIN; CARBON DIOXIDE; CHLORIDES; ETHANOL; FLUNITRAZEPAM; GABA MODULATORS; METHOXYFLURANE; MICE; MICE, INBRED ICR; PENTOBARBITAL; RECEPTORS, GABA;

EID: 0029813282     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Paul, S. M., and R H. Purdy. 1992. Neuroactive steroids. FASEB J. 6:2311-2322.
2. Deutsch, S. I., J. Mastropaolo, and A. Hitri. 1992. GABA-active steroids: endogenous modulators of GABA-gated chloride ion conductance. Clin. Neuropharmacol. 15:352-364.
3. Weight, F. F., L. G. Aguayo, G. White, et al. 1992. GABA-and glutamate-gated ion channels as molecular sites of alcohol and anesthetic action. Adv. Biochem. Psychopharmacol. 47:335-347.
4. - current correlates with in vivo anesthetic potency. J. Pharmacol. Exp. Ther. 270:987-991.
5. Mihic, S. J., S. J. McQuilkin, E. I. Eger II, et al. 1994. Potentiation of γaminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia. Mol. Pharmacol. 46:851-857.
6. Harrison, N. L., J. L. Kugler, M. V. Jones, et al. 1993. Positive modulation of human γaminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane. Mol. Pharmacol. 44:628-632.
7. Quinlan, J. J., E. J. Gallaher, and L. L. Firestone. 1993. Halothane's effects on GABA-gated chloride flux in mice selectively bred for sensitivity or resistance to diazepam. Brain Res. 610:224-228.
8. Harris, B. D., E. J. Moody, A. S. Basile, et al. 1994. Volatile anesthetics bidirectionally and stereospecifically modulate ligand binding to GABA receptors. Eur. J. Pharmacol. 267:269-274.
9. A receptor complex. Brain Res. 615:101-106.
10. Harris, B., G. Wong, and P. Skolnick. 1993. Neurochemical actions of the inhalational anesthetics at the GABAA receptor complex. J. Pharmacol. Exp. Ther. 265:1392-1398.
11. McQuilkin, S. J., and R. A. Harris. 1990. Factors affecting actions of ethanol on GABA-activated chloride channels. Life Sci. 46:527-541.
12. Andrews, E. J., B. T. Bennett, J. D. Clark, et al. 1993. Report of the AVMA panel on euthanasia. J. Am. Vet. Med. Assoc. 202:230-249.
13. Woods, S. W., D. S. Charney, J. Loke, et al. 1986. Carbon dioxide sensitivity in panic anxiety. Arch. Gen. Psychiatry. 43:900-909.
14. Sanna, E., T. Cuccheddu, M. Serra, et al. 1992. Carbon dioxide inhalation reduces the function of GABAA receptors in the rat brain. Eur. J. Pharmacol. 216:457-458.
15. Concas, A., E. Sanna, T. Cuccheddu, et al. 1993. Carbon dioxide inhalation, stress and anxiogenic drugs reduce the function of GABAA receptors in the rat brain. Prog. Neuropsychopharmacol. Biol. Psychiatr. 17:651-661.
16. Mischler, S. A., M. Alexander, A. H. Battles, et al. 1994. Prolonged antinociception following carbon dioxide anesthesia in the laboratory rat. Brain Res. 640:322-327.
17. Berger-Sweeney, J., U. V. Berger, M. Sharma, et al. 1994. Effects of carbon dioxide-induced anesthesia on cholinergic parameters in rat brain. Lab. Anim. Sci. 44:369-371.
18. Lumb, W. V., and E. V. Jones. 1984. Veterinary anesthesia, p. 200-201. Lea & Febiger, Philadelphia.
19. Allan, A. M., and R. A. Harris. 1986. γAminobutyric acid agonist and antagonist alter chloride flux across brain membranes. Mol. Pharmacol. 29:497-505.
20. Lowry, O. H., N. J. Rosebrough, A. L. Farr, et al. 1951 Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:256-275.
21. Huidobro-Toro, J. P., V. Bleck, A. M. Allan, et al. 1987. Neurochemical actions of anesthetic drugs on the γaminobutyric acid receptor-chloride channel complex. J. Pharmacol. Exp. Ther. 242:963-969.
22. A receptor function and binding by the volatile anesthetic halothane. J. Pharmacol. Exp. Ther. 266:153-159.
23. Quinlan, J. J., and L. L. Firestone. 1992. Ligand-dependent effects of ethanol and diethylether at brain benzodiazepine receptors. Pharmacol. Biochem. Behavior. 42:787-790.
24. Allan, A. M., and R. A. Harris. 1987. Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels. Pharmacol. Biochem. Behav. 27:665-670.
25. A receptor-operated chloride channels. I. Acute effects of ethanol. J. Pharmacol. Exp. Ther. 253:706-712.
26. Moody, E. J., P. D. Suzdak, S. M. Paul, et al. 1988. Modulation of the benzodiazepine/ γaminobutytic acid receptor chloride channel complex by inhalation anesthetics. J. Neurochem. 51:1386-1393.
27. 2 buffering capacity in respiratory acidosis and alkalosis. J. Appl. Physiol. 22:241-246.
28. - formation in cerebrospinal fluid. J. Appl. Physiol. 47:471-477.