Pentoxifylline therapy in human immunodeficiency virus-seropositive persons with tuberculosis: A randomized, controlled trial

Journal of Infectious Diseases

Volumn 174, Issue 4, 1996, Pages 727-733

  Wallis, R S ^a   Nsubuga, P ^b   Whalen, C ^b   Mugerwa, R D ^b   Okwera, A ^b   Oette, D ^b   Jackson, J B ^b   Johnson, J L ^b   Ellner, J J ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; ETHAMBUTOL; HEMOGLOBIN; ISONIAZID; PENTOXIFYLLINE; PLACEBO; PYRAZINAMIDE; RIFAMPICIN; TUBERCULOSTATIC AGENT; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA;

ADULT; ANEMIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MYCOBACTERIUM TUBERCULOSIS; NEUROTOXICITY; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; STEVENS JOHNSON SYNDROME; SUSTAINED RELEASE PREPARATION; UGANDA;

EID: 0029813078     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/174.4.727     Document Type: Article

References (13)

1. Villarino ME, Dooley SW, Geiter LJ, Castro KG, Snider DE Jr. Management of persons exposed to multidrug-resistant tuberculosis. MMWR Morb Mortal Wkly Rep 1992;41(RR-11):61-71.
2. Whalen C, Horsburgh CR, Horn D, Lahart C, Simberkoff M, Ellner J. Accelerated course of human immunodeficiency virus infection after tuberculosis. Am J Respir Crit Care Med 1995;151:129-35.
3. Nunn P, Brindle R, Carpenter L, et al. Cohort study of human immunodeficiency virus infection in patients with tuberculosis in Nairobi, Kenya. Analysis of early (6-month) mortality. Am Rev Respir Dis 1992;146: 849-54.
4. Brindle RJ, Nunn PP, Githui W, Allen BW, Gathua S, Waiyaki P. Quantitative bacillary response to treatment in HIV-associated pulmonary tuberculosis. Am Rev Respir Dis 1993;147:958-61.
5. Githui W, Nunn P, Juma E, et al. Cohort study of HIV-positive and HIV-negative tuberculosis, Nairobi, Kenya: comparison of bacteriological results. Tuber Lung Dis 1992;73:203-9.
6. Okwera A, Whalen C, Byekwaso F, et al. A randomized trial of thiacetazone- and rifampin-containing therapies for pulmonary tuberculosis in HIV-infected Ugandans. Lancet 1994;344:1323-8.
7. 2-microglobulin in HIV-1-associated tuberculosis. J Infect Dis 1993;167:43-8.
8. Kindler V, Sappino AP, Grau GE, Piguet PF, Vassalli P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 1989;56:731-40.
9. Kinter AL, Poli G, Maury W, Folks TM, Fauci AS. Direct and cytokine-mediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells. J Virol 1990;64:4306-12.
10. Griffin GE, Leung K, Folks TM, Kunkel S, Nabel GJ. Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression. Res Virol 1991;142:233-8.
11. Lederman MM, Georges DL, Kusner DJ, Mudido P, Giam CZ, Toossi Z. Mycobacterium tuberculosis and its purified protein derivative activate expression of the human immunodeficiency virus. J Acquir Immune Defic Syndr 1994;7:727-33.
12. Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA. Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 1991;110:192-8.
13. Lilly CM, Sandhu JS, Ishizaka A, et al. Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am Rev Respir Dis 1989;139: 1361-8.