Interaction between midazolam and clarithromycin: Comparison with azithromycin

International Journal of Clinical Pharmacology and Therapeutics

Volumn 34, Issue 9, 1996, Pages 400-405

  Yeates, R A ^a   Laufen, H ^a   Zimmermann, T ^a  

^a PFIZER INC   (United States)

Author keywords

Azalide; Azithromycin; Clarithromycin; Drug interaction; Hypnotic; Macrolide; Midazolam

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN; MIDAZOLAM MALEATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HYPERSENSITIVITY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; RANDOMIZED CONTROLLED TRIAL; SLEEP; STATISTICAL ANALYSIS;

ADULT; ANALYSIS OF VARIANCE; ANTI-ANXIETY AGENTS; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CLARITHROMYCIN; CROSS-OVER STUDIES; DRUG INTERACTIONS; FEMALE; HUMANS; MALE; MIDAZOLAM; MIDDLE AGED; SLEEP;

EID: 0029813001     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Allonen H, Ziegler G, Klotz U 1981 Midazolam kinetics. Clin Pharmacol Ther 30: 653-661
2. Amrein R, Hetzel W 1991 Pharmacology of drugs frequently used in ICUS: midazolam and flumazenil. Intensive Care Med 17: S1-S10
3. Backman JT, Aranko K, Himberg J-J, Olkkola KT 1994 A pharmacokinetic interaction between roxithromycin and midazolam. Eur J Clin Pharmacol 46: 551-555
4. Backman JT, Olkkola KT, Neuvonen PJ 1995 Azithromycin does not increase plasma concentrations of oral midazolam. Int J Clin Pharmacol Ther 13: 356-359
5. Bebin M, Bleck TP 1994 New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol. Drugs 48: 153-171
6. Bond A, Lader MH 1974 The use of visual analogue scales in rating subjective feelings. Br J Med Psychol 47: 211-218
7. Dundee JW, Halliday NJ, Harper KW, Brogden RN 1984 Midazolam. A review of its pharmacological properties and therapeutic use. Drugs 28: 519-543
8. Foulds G, Shepard RM, Johnson RB 1990 The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 25: 73-82
9. Gascon M-P, Dayer P 1991 In vitro forecasting of drugs which may interfere with the biotransformation of midazolam. Eur J Clin Pharmacol 41: 573-578
10. Gladue RP, Bright GM, Isaacson RE, Newborg MF 1989 In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanisms of delivery and release at sites of infection. Antimicrob Agents Chemother 33: 277-282
11. Hiller A, Olkkola KT, Isohanni P, Saarnivaara L 1990 Unconsciousness associated with midazolam and erythromycin. Br J Anaesth 65: 826-828
12. Hollander M, Wolfe DA 1973 Non-parametric statistical methods. John Wiley and Sons, Chichester, pp 138-184
13. Jacqz-Aigrain E, Daoud P, Burtin P, Desplanques L, Beaufils F 1994 Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies. Lancet 344: 646-650
14. Kupietzky A, Houpt MI 1993 Midazolam: a review of its use for conscious sedation of children. Ped Dentist 15: 237-241
15. Mattila MJ, Vanakoski J, Idänpään-Heikkilä JJ 1994 Azithromycin does not alter the effects of oral midazolam on human performance. Eur J Clin Pharmacol 47: 49-52
16. Olkkala KT, Aranko K, Luurila H, Hiller A, Saarnivaara L, Hinberg J-J, Neimmen PJ 1993 A potentially hazardous interaction between erythromycin and midazolam. Clin Pharmacol Ther 5: 298-305
17. Peters DH, Clissold SP 1992 Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Drugs 44: 117-164
18. Peters DH, Friedel HA, McTavish D 1992 Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy. Drugs 44: 750-799
19. Smith JM, Misiak H 1976 Critical flicker frequence (CFF) and psychotropic drugs in normal human subjects - a review. Psychopharmacology 47: 175-182
20. Smith MR, Bell GD, Quine MA, Spencer GM, Morden AE, Jones JG 1993 Small bolus injections of intravenous midazolam for upper gastrointestinal endoscopy: a study of 788 consecutive cases. Br J Clin Pharmacol 36: 573-578
21. Stone BI 1984 Pencil and paper tests - sensitivity to psychotropic drugs. Br J Clin Pharmacol 18: 15-20
22. Wrighton SA, Ring BJ 1994 Inhibition of human CYP 3A catalyzed 1′-hydroxymidazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine and nizatidine. Pharm Res 11: 921-924
23. Zimmermann T, Laufen H, Yeates RA 1995 A comparative study of the effects of azithromycin and erythromycin on the pharmacokinetics and pharmacodynamics of midazolam. In preparation