Inhibition of collagen expression by azelastine hydrochloride in cultured skin fibroblasts from normal individuals and scleroderma patients

Archives of Dermatological Research

Volumn 288, Issue 10, 1996, Pages 575-578

  Yamada, H ^a,b   Tajima, S ^a  

^a KEIO UNIVERSITY   (Japan)

^b Division of Dermatology   (Japan)

Author keywords

Azelastine; Collagen; Scleroderma; Skin fibroblast

Indexed keywords

AZELASTINE; COLLAGEN; MESSENGER RNA;

ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; INHIBITION KINETICS; NORTHERN BLOTTING; PRIORITY JOURNAL; RNA TRANSLATION; SCLERODERMA; SKIN FIBROBLAST; SKIN FIBROSIS;

EID: 0029812961     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02505259     Document Type: Article

References (23)

1. Krieg T, Perlish JS, Mauch C, Fleischmajer R (1985) Collagen synthesis by scleroderma fibroblasts. Ann NY Acad Sci 460: 375-386
2. Murray JC, Pollack SV, Pinnel SR (1981) Keloid: a review. J Am Acad Dermatol 4:461-470
3. Raghow R, Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH (1987) Transforming growth factor-β increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J Clin Invest 79:1285-1288
4. Fine A, Goldstein RH (1987) The effect of transforming growth factor-β on cell proliferation and collagen formation by lung fibroblasts. J Biol Chem 262:3897-3902
5. Kurata S, Hata R (1991) Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative. J Biol Chem 266:9997-10003
6. Kähäri VM, Heino J, Vuorio E (1987) Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts. Biochim Biophys Acta 929:142-147
7. Goldring MB, Krane SM (1987) Modulation by recombinant interleukin-1 of synthesis of type I and III collagens and associated procollagen mRNA levels in cultured human cells. J Biol Chem 262:16724-16729
8. Solis-Herruzo JA, Brenner DA, Chojkier M (1988) Tumor necrosis factor α inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J Biol Chem 263: 5841-5845
9. Jimenez SA, Freundlich B, Rosenbloom J (1984) Selective inhibition of human diploid fibroblasts collagen synthesis by interferons. J Clin Invest 74:1112-1119
10. Zechel HJ, Brock N, Lenke D, Achterrath-Tuckermann U (1981) Pharmacological and toxicological properties of azelastine, a novel antiallergic agent. Arzneimittelforschung 31:1184-1193
11. Katayama S, Akimoto N, Shionoya H, Morimoto T, Katoh Y (1981) Antiallergic effects of azelastine hydrochloride on immediate type hypersensitivity reactions in vivo and in vitro. Arzneimittelforschung 31:1196-1203
12. Chand N, Harrison JE, Rooney SM, Sofi RD, Diamantis W (1985) Inhibition of passive cutaneous anaphylaxis (PCA) by azelastine: dissociation of its antiallergic activities from antihistamic and antiserotonin properties. Int J Immunopharmacol 7:833-838
13. Chand N, Pillar J, Diamantis W, Perhach JL Jr, Sofia RD (1983) Inhibition of calcium ionophore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastin: implications for its mode of action. Eur J Pharmacol 96:227-233
14. Furue M, Osada A, Chang C-H, Tamaki K (1994) Immunosuppressive effects of azelastin hydrochloride on contact hypersensitivity and T-cell proliferative response: a comparative study with FK-506. J Invest Dermatol 103:49-53
15. Peterkofsky B, Diegelmann R (1971) Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemistry 1:988-994
16. 1 (III) collagens. Arch Biochem Biophys 295:397-403
17. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-195
18. 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution. Biochemistry 22:5213-5223
19. 1 (III) collagen. J Biol Chem 260:4357-4363
20. Chu M-L, Conway D, Pan T, Baldwin C, Mann K, Deutzmann R, Timpl R (1988) Amino acid sequence of the triple-helical domain of human collagen type VI. J Biol Chem 263:18601-18606
21. Fort P, Marty L, Piechaczyk M, Sabrouty SE, Dani D, Jeanteur P, Blanchard JM (1985) Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res 13: 1431-1442
22. Heckmann M, Aumailley M, Chu M-L, Timpl R, Krieg T (1992) Effect of transforming growth factor-β on collagen type VI expression in human dermal fibroblasts. FEBS Lett 310: 79-82
23. 3 (VI) chain expression by γ-interferon decreases synthesis and deposition of collagen type VI. Eur J Biochem 182:719-726