Construction of phosphorylatable monoclonal antibody to a tumor- associated antigen

Cancer Research

Volumn 56, Issue 18, 1996, Pages 4250-4254

  Lin, Lei ^a   Daugherty, Bruce ^a,b   Schlom, Jeffrey ^c   Pestka, Sidney ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; CYCLIC AMP DEPENDENT PROTEIN KINASE; MONOCLONAL ANTIBODY B.72.3; TUMOR ANTIGEN;

ADENOCARCINOMA; ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOMA; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA PRIMERS; FEMALE; GLYCOPROTEINS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0029811966     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Reynolds, J. G., Del Vecchio, S., Sakahara, H , Lora, M. E , Carrasquillo, J A., Neumann, R. D , and Larson, S M. Anti-murine response to mouse monoclonal antibodies, clinical findings and implications Nucl. Med. Biol , 16. 121-125, 1989
2. Seccamani, E , Tattenelli, M., Mariani, M., Spranzi, E., Scassellati, G. A., and Siccard, A. G. A. A simple qualitative determination of human antibodies to murine immunoglobulins (HAMA) in serum samples. Nucl. Med. Biol , 16: 167-170, 1989.
3. Morrison, S. L., Johnson, M. J., Herzenberg, L. A., and Oi, V. T. Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains Proc. Natl. Acad. Sci. USA, 81 6851-6855, 1984.
4. Schlom, J. Basic principle and application of monoclonal antibodies in the management of carcinomas, the Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res., 46. 3225-3238, 1986
5. Hand, P. H., Robbins, P. F., Salgaller, M. L., Poole, D J , and Schlom, J. Evaluation of human carcinoembryonic-antigen (CEA)-transduced and non-transduced murine tumors as potential targets for anti-CEA therapies. Cancer Immunol. Immunother., 36: 65-75, 1993
6. 131I-CC49) when given in combination with γ-interferon. Cancer Res., 53: 600-608, 1993
7. Primus, F. J , Finch, M D., Masci, A. M., Schlom, J., and Kashmiri, S V. S. Self-reactive antibody expression by human carcinoma cells engineered with monoclonal antibody genes. Cancer Res., 53, 3355-3361, 1993.
8. Guadagni, F., Roselli, M., Ferron, P., Amato, T , Colcher, D., Greiner, J. W., and Schlom, J Clinical evaluation of the new tumor marker TAG-72 Anticancer Res , 11: 1389-1394, 1991
9. Colcher, D, Hand, P. H, Nuti, M , and Schlom, J. A spectrum of monoclonal antibodies reactive with human mammary tumor cells. Proc. Natl. Acad. Sci USA, 78: 3199-3203, 1981.
10. Colcher, D., Milenic, D E., Ferroni, P., Roselli, M., and Schlom, J. In vivo and in vitro clinical applications of monoclonal antibodies against TAG-72. Int J. Radiat. Appl Instrum Part B, 18: 395-401, 1991.
11. Li, B-L., Langer, J. A , Schwartz, B., and Pestka, S. Creation of phosphorylation sites in proteins: construction of a phosphorylatable human interferon α Proc. Natl Acad. Sci. USA, 86: 558-562, 1989.
12. Zhao, X-X., Li, B-L , Langer, J. A., Van Piper, G., and Pestka, S. Construction and phosphorylation of a fusion protein Hu-IFN-αA/γ. Anal. Biochem , 178 342-347, 1989.
13. Wang, P., Izotova, L., Mariano, T. M., Donnelly, R. J., and Pestka, S. Construction and activity of phosphorylatable human interferon-αB2 and interferon-αA/D. J Interferon Res., 14: 41-46, 1994.
14. Mariano, T M., and Pestka, S Receptor-binding studies In. F. R Balkwill (ed ), Cytokines - A Practical Approach, pp. 95-108. Oxford, UK: Oxford University Press, 1991
15. Groger, R. K , Morrow, D. M., and Tykocinski, M. L Directional antisense and sense cDNA cloning using Epstein-Barr virus episomal expression vectors. Gene (Amst ), 81: 285-294, 1989.
16. Nishimuro, A., Monta, M., Nisbimura, Y., and Sugino, Y. A rapid and highly efficient method for preparation of competent Escherichia coli cells. Nucleic Acids Res , 18: 6169, 1990.
17. Greiner, J. W., Tobi, M., Fisher, P B., Langer, J A , and Pestka, S. Differential responsiveness of cloned mammary carcinoma cell populations to the human recombinant leukocyte interferon enhancement of tumor antigen expression. Int. J. Cancer, 36: 159-166, 1985.
18. Hutzell, P., Kashmiri, S., Colcher, D., Primus, F , Hand, P. H., Roselli, M., Finch, M., Yamanton, G., Bodmer, M., Whittle, N , King, D, Loullis, C. C , McCoy, D. W., Callahan, R , and Schlom, J. Generation and characterization of a recombinant/ chimeric B72.3 (human γ1). Cancer Res., 51: 181-189, 1991.
19. Daugherty, B. L , DeMartino, J. A., Law, M. F., Kawka, D. W., Singer, I. I., and Mark, G. E. Polymerase chain reaction facilitates the cloning, CDR-grafting, and rapid expression of a murine monoclonal antibody directed against the CD18 component of leukocyte integrins. Nucleic Acids Res., 19: 2471-2476, 1991.
20. Pestka, S. Studies in transfer ribonucleic acid-ribosome complex J. Biol. Chem., 247. 4669-4678, 1972.
21. Greiner, J W., Guadagni, F., Noguchi, P., Pestka, S , Colcher, D., Fisher, P. B., and Schlom, J. Recombinant interferon enhances monoclonal antibody-targeting of carcinoma lesions in vivo. Science (Washington DC), 235: 895-898, 1987.
22. Greiner, J W , Hand, P H., Noguchi, P , Fisher, P. B , Pestka, S., and Schlom, J. Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte α-interferon treatment. Cancer Res , 44: 3208-3214, 1984.
23. Guadagni, F., Schlom, J., Johnson, W. W., Szpak, C. Z., Goldstein, D., Smalley, R., Simpson, J. F., Borden, E. C , Pestka, S., and Greiner, J. W Selective interferon-induced enhancement of tumor-associated antigens on a spectrum of freshly isolated human adenocarcinoma cells. J. Natl. Cancer Inst., 81: 502-512, 1989.
24. Scatchard, G. Attraction of proteins for small molecules and ions. Ann NY Acad Sci., 51: 660-672, 1949.