The regulation mechanism of HLA class II gene expression at the level of mRNA stability

Immunogenetics

Volumn 44, Issue 6, 1996, Pages 453-458

  Del Pozzo, Giovanna ^a   Guardiola, John ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; MESSENGER RNA; PROTEIN SYNTHESIS INHIBITOR; PUROMYCIN; TRANS ACTING FACTOR;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HALF LIFE TIME; HUMAN; HUMAN CELL; HYDROLYSIS; POLYSOME; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAJI CELL; RNA DEGRADATION; RNA TRANSLATION; TRANSCRIPTION REGULATION;

EID: 0029811318     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02602807     Document Type: Article

References (32)

1. Altus, M. S. and Nagamine, Y. Protein synthesis inhibition stabilizes urokinase-type plasminogen activator mRNA. Studies in vivo and in cell decady reactions. J Biol Chem 266: 21 190-21 196, 1991
2. Aharon, T. and Schneider, R. J. Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3′ noncoding region is mediated by a cotraslational mechanism. Mol Cell Biol 13: 1971-1980, 1993
3. Bandyopadhyay, R., Coutts, M., Krowczynska, A., and Brawerman, G. Nuclease activity associated with mammalian mRNA in its native state: possible basis for selectivity in mRNA decady. Mol Cell Biol 10: 2060-2069, 1990
4. Beelman, C. A. and Parker, R. Degradation of mRNA in eukariotes. Cell 81: 179-182, 1995
5. Bernstein, P., Peltz, W., and Ross, J. The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro. Mol Cell Biol 9: 659-670, 1989
6. Bernstein, P. L., Herrick, D. J., Prokipcak, R. D., and Ross, J. Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant. Genes Dev 6: 642-665, 1992
7. Binder, R., Horowitz, J. A., Basilion, J. P., Koeller, D. M., Klausner, R. D., and Harford, J. B. Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening. EMBO J 13: 1969-1980, 1994
8. Brewer, G. and Ross, J. Poly(A) shortening and degradation of the 3′ A+U-rich sequences of human c-myc mRNA in a cell-free system. Mol Cell Biol 8: 1697-1708, 1988
9. Brewer, G. and Ross, J. Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component. Mol Cell Biol 9: 1996-2006, 1989
10. Brewer, G. and Ross, J. Messenger RNA turnover in cell-free extracts. Meth Enzymol 181: 202-209, 1991
11. Chen, C. Y., You, Y., and Shyu, A. B. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Mol Cell Biol 14: 8471-8482, 1994
12. Constable, A., Quick, S., Gray, N. K., and Hentze, M. W. Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function? Proc Natl Acad Sci USA 89: 4554-4558, 1992
13. Del Pozzo, G., Ciullo, M., Autiero, M., and Guardiola, J. Control of nucleo-cytoplasmic HLA-DRA mRNA partitioning by interaction of a retention signal with compartimentalized proteins. J Mol Biol 240: 193-204, 1994
14. Gay, D. A., Sangram, S. S., and Cleveland, W. Autoregulatory control of β-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci USA 86: 5763-5767, 1989
15. Giles, R. C. and Capra, J. D. Structure, function and genetics of human MHC class II molecules. Adv Immunol 37: 1-7, 1985
16. Graves, R. A., Pandey, N. B., Chodchoy, N., and Marzluff, W. F. Translation is required for regulation of histone mRNA degradation. Cell 48: 615-626, 1987
17. Guardiola, J. and Maffei, A. Control of MHC class II gene expression in autoimmune, infectious, and neoplastic diseases. Crit Rev Immunol 13: 247-268, 1993
18. Hentze, M. W. and Argos, P. Homology between IRE-BP, a regulatory RNA-binding protein, aconitase and isopropylmalate isomerase. Nucleic Acids Res 19: 1739-1740, 1991
19. Herrick, D. J. and Ross, J. The half-life of c-myc mRNA in growing and serum-stimulated cells: influence in the coding and 3′ untranslated regions and role of ribosome translocation. Mol Cell Biol 14: 2119-2128, 1994
20. Maffei, A., Perfetto, C., Ombra, N., Del Pozzo, G., and Guardiola, J. Transcriptional and post-transcriptional regulation of human MHC class II genes require the synthesis of short-lived proteins. J Immunol 142: 3657-3661, 1989
21. Mullner, E. W. and Kuhn, L. C. A stem loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell 53: 815-825, 1988
22. Pachter, J. S., Ven, T. J., and Cleveland, W. Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell 51: 283-292, 1987
23. Pandey, N. B. and Marzluff, W. F. The stem-loop structure at the 3′ end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability. Mol Cell Biol 7: 4557-4559, 1987
24. Peltz, S. W. and Ross, J. Autogenous regulation of histone mRNA decay by histone proteins in a cell-free system. Mol Cell Biol 7: 4345-4356, 1987
25. Ross, J., Kobs, G., and Brewer, G. H4 histone mRNA decay in cell-free extracts initiates at or near the 3′ terminus and proceeds 3′ to 5′. J Mol Biol 188: 579-593, 1986
26. Sachs, A. The role of poly(A) in the translation and stability of mRNA. Curr Opin Cell Biol 2: 1092-1098, 1990
27. Sachs, A. B. Messenger RNA degradation in Eukaryiotes. Cell 74: 413-421, 1993
28. Schiavi, S. C., Wellington, C. L., Shyu, A. B., Chen, C. Y., Greenberg, M. E., and Belasco, J. G. Multiple elements in the c-fos protein coding region facilitate deadenylation and decady by a mechanism coupled to translation. J Biol Chem 269: 3441-3448, 1994
29. Ting, J. P. and Baldwin, A. S. Regulation of MHC gene expression. Curr Op Immunol 5: 8-16, 1993
30. Vakalopoulou, E., Schaack, J., and Shenk, T. A 32-kilodalton protein binds to AU-rich domains in the 3′-untranslated regions of rapidly degraded mRNAs. Mol Cell Biol 11: 3355-3364, 1991
31. Veyrune, J. L., Carillo, S., Vie, A., and Blanchard, J. M. c-fos mRNA instability determinants present within both the coding region and the 3′ non coding region link the degradation of this mRNA to its translation. Oncogene 11: 2127-2134, 1995
32. Wellington, C. L., Greenberg, M. E., and Belasco, J. G. The destabilizing elements in the coding region of c-fos mRNA are recognized as RNA. Mol Cell Biol 13: 5034-5042, 1993