Preterm birth in rats produced by the synergistic action of a nitric oxide inhibitor (N(G)-nitro-L-arginine methyl ester) and an antiprogestin (onapristone)

American Journal of Obstetrics and Gynecology

Volumn 175, Issue 1, 1996, Pages 207-212

  Yallampalli, C ^a   Buhimschi, I ^a   Chwalisz, K ^a   Garfield, R E ^a   Dong, Y L ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

antiprogesterone; Nitric oxide; pregnancy; preterm labor; uterus

Indexed keywords

ANTIGESTAGEN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; ONAPRISTONE;

ANIMAL EXPERIMENT; ARTICLE; CHILDBIRTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG MIXTURE; DRUG POTENTIATION; FEMALE; GESTATIONAL AGE; NONHUMAN; OSMOTIC MINIPUMP; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029810914     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(96)70276-4     Document Type: Article

References (13)

1. C Yallampalli RE Garfield M Byam-Smith Nitric oxide inhibits uterine contractility during pregnancy but not during delivery Endocrinology 133 1993 1899 1902
2. C Yallampalli H Izumi M Byam-Smith RE Garfield An L-arginine - nitric oxide - cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy Am J Obstet Gynecol 170 1994 175 185
3. C Yallampalli M Byam-Smith S Nelson RE Garfield Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus Endocrinology 134 1994 1971 1974
4. ES Natuzzi PC Ursell M Harrison C Buscher RK Riemer Nitric oxide synthase activity in the pregnant uterus decreases at parturition Biochem Biophys Res Commun 194 1993 1 8
5. SM Sladek AC Regenstein D Lykins JM Roberts Nitric oxide synthase activity in pregnant rabbit uterus decreases on the last day of pregnancy Am J Obstet Gynecol 169 1993 1285 1291
6. C Yallampalli RE Garfield Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia Am J Obstet Gynecol 169 1993 1316 1320
7. AL Csapo Force of labor L Iffy HA Kaminetzky Principles and practice of obstetrics and perinatology 1981 John Wiley New York 761 799
8. RE Garfield EE Baulieu The antiprogesterone steroid RU 486: a short pharmacological and clinical review, with emphasis on the interruption of pregnancy Baillieres Clin Endocrinol Metab 1 1987 207 221
9. EE Baulieu RU 486: an antiprogestin with contragestive activity in women EE Baulieu SJ Segal The antiprogestin steroid RU 486 and human fertility Control 1985 Plenum Press New York 1 25
10. RE Garfield JM Gasc EE Baulieu Effects of the antiprogesterone RU 486 on preterm birth in the rat Am J Obstet Gynecol 157 1987 1281 1285
11. RE Garfield S Beier Increased myometrial responsiveness to oxytocin during term and preterm labor Am J Obstet Gynecol 161 1989 454 461
12. W Elger K Chwalisz M Fahnrich SH Hasan D Laurent S Beier Studies on labor-conditioning and labor-inducing effects of antiprogesterones in animal models RE Garfield Uterine contractility: mechanisms of control 1990 Serono Symposia Norwell (MA) 153 176
13. M Bygdeman M-L Swahn KG Danielsson C Gottlieb The use of progesterone antagonists in combination with prostaglandin for termination of pregnancy Hum Reprod 9 1994 121 125