Daidzin decreases ethanol consumption in rats

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 6, 1996, Pages 1083-1087

  Heyman, Gene M ^a   Keung, Wing Ming ^b   Vallee, Bert L ^b  

^a HARVARD UNIVERSITY   (United States)

^b NONE

Author keywords

Daidzin; Ethanol Consumption; Ethanol Preference; Kudzu Plant; Rats

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE INHIBITOR; CALCIUM CARBIMIDE; DAIDZIN; SACCHARIN; UNCLASSIFIED DRUG;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DEVELOPMENT; FOOD INTAKE; HERBAL MEDICINE; MALE; MEDICINAL PLANT; NONHUMAN; PHARMACOLOGY; PRIORITY JOURNAL; RAT; SYRIAN HAMSTER; THIRST;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS; PUERARIA MONTANA VAR. LOBATA;

EID: 0029810731     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01950.x     Document Type: Article

References (22)

1. Galanter M: Recent Developments in Alcoholism, vol 4. New York, Plenum Press, 1986
2. Gordis E: Critical issues in alcoholism research. Int J Addict 30:497-505, 1995
3. Myers RD: Psychopharmacology of alcohol. Ann Rev Pharmacol Tox 18:125-144, 1978
4. Volpicelli JR: Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880, 1992
5. Keung WM, Vallee BL: Daidzin: A potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc Nat Acad Sci USA 90:1247-1251, 1993a
6. Keung WM, Vallee BL: Daidzin and daidzein suppress free-choice ethanol intake by Syrian Golden hamsters. Proc Nat Acad Sci USA 90:10,0008-10,012, 1993b
7. Keung WM, Vallee BL: Daidzin suppresses ethanol consumption by Syrian Golden hamsters without blocking acetaldehyde metabolism. Proc Nat Acad Sci USA 92:8990-8993, 1995
8. Sun S.-M: Beiji-Qiamijin-Yaofang (Circa 600 AD)
9. Tipton KF, Henehan GT, Harrington MC: Cellular and intracellular distribution of acetaldehyde dehydrogenases, in Crow KE, Batt RC (eds): Human Metabolism of Alcohol: Regulation, Enzymology, and Metabolites of Ethanol, vol 2. Boca Raton, FL CRC Press, 1989 pp 105-116
10. Heyman GM: Ethanol regulated preference in rats. Psychopharmacology 112:259-269, 1993
11. Heyman GM: Robust preferences for flavored alcohol relative to isocaloric food sources in rats. Alcohol Clin Exp Res 19:12a, 1995 (abstr)
12. Files F, Samson HH, Brice GT: Sucrose, ethanol, and sucrose/ethanol reinforced responding under variable-interval schedules of reinforcement. Alcohol Clin Exp Res 19:1271-1278, 1995
13. Tatham TA, Zurn KR: The MED-PC experimental apparatus programming system. Behav Res Methods Instrum Comput 21:294-302, 1989
14. Herrnstein RJ: Relative and absolute strength of response as a function of frequency of reinforcement. J Exp Anal Behav 4:267-272, 1961
15. Herrnstein RJ: On the law of effect. J Exp Anal Behav 13:243-266, 1970
16. Williams BA: Reinforcement, choice, and response strength, in Atkinson RC, Herrnstein RJ, Lindzey G, Luce RD (eds): Stevens Handbook of Experimental Psychology, vol 2: Learning and Cognition, ed 2. New York: Wiley, 1988 pp 167-244
17. Fleshier M, Hoffman HS: A progression for generating variable interval schedules. J Exp Anal Behav 5:529-530, 1962
18. Levitt MD, Furne J, DeMaster EG: Magnitude, origin, and implications of the discrepancy between blood ethanol concentrations of tail vein and arterial blood of the rat. Alcohol Clin Exp Res 18:1237-1241, 1994
19. Goedde HW, AgarwaJ DP: Pharmacogenetics of aldehyde dehydrogenase (ALDH). Pharmacol Ther 45:345-371, 1990
20. Sinclair JD, Lindros KO: Suppression of alcohol drinking with brain aldehyde dehydrogenase inhibition. Pharmacol Biochem Behav 14:377-383, 1981
21. Xie C-I, Lin RC, Antony V, Lumeng L, Li T-K, Mai K, Liu C, Wang Q-D, Zhao Z-H, Wang GF: Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. Alcohol Clin Exp Res 18:1443-1447, 1994
22. Overstreet DH, Lee Y-W, Rezvani AH, Pei Y-Hm, Criswell HE, Janowsky DS: Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. Alcohol Clin Exp Res 20:221-227, 1996