Immunologic effects of encapsulated short ragweed extract: A potent new agent for oral immunotherapy

Annals of Allergy, Asthma and Immunology

Volumn 77, Issue 2, 1996, Pages 132-138

  Litwin, Allen ^a   Flanagan, Michael ^a   Entis, Gregory ^a   Gottschlich, Gregory ^a   Esch, Robert ^b   Gartside, Peter ^b   Michael, J Gabriel ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b College of Medicine ML524 ^*

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ATOPY; CLINICAL ARTICLE; DRUG EFFECT; DRUG POTENCY; HUMAN; IMMUNOTHERAPY; MICROENCAPSULATION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAGWEED POLLEN;

EID: 0029810526     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)63499-0     Document Type: Article

References (26)

1. Frankland AW, Augustin R. Prophylaxis of Summer hay-fever and asthma: a controlled trial comparing crude grass-pollen extracts with the isolated main protein component. Lancet 1954;1:1055-7.
2. Lowell FC, Franklin W. A 'double-blind' study of treatment with aqueous allergenic extracts in cases of allergic rhinitis. J Allergy 1963;34:165-82.
3. Van Metre Jr. TE, Marsh DG, Adkinson NF Jr, et al. Immunotherapy for cat asthma. J Allergy Clin Immunol 1988;82:1055-67.
4. Hunt KJ, Sobotka AK, Amodio FJ, et al. A controlled trial of immunotherapy in insect hypersensitivity. N Engl J Med 1978;299:257-61.
5. Taudorf E, Larsen LC, Lanner Å, et al. Oral immunotherapy in birch pollen hay fever. J Allergy Clin Immunol 1987;80:153-61.
6. Creticos PS, Nuclerio KM, Adkinson NF, Norman PS. Efficacy, safety, and kinetics of oral ragweed immunotherapy in the treatment of allergic seasonal rhinitis [Abstract]. J Allergy Clin Immunol 1990;85:165.
7. Van Niekerk CH, De Wet JL. Efficacy of grass-maize pollen oral immunotherapy in patients with seasonal hay-fever: a double-blind study. Clin Allergy 1987;17:507-13.
8. Mosbech H, Dreboug S, Madsen F, et al. High dose grass pollen tablets used for hyposensitization in hay-fever patients. A one-year double blind placebo-controlled study. Allergy 1987;42: 451-5.
9. Urbanek R, Bürgelin KH, Kahle S, et al. Oral immunotherapy with grass pollen in enterosoluble capsules. A prospective study of the clinical and immunological response. Eur J Pediatr 1990;149:545-50.
10. Oppenheimer J, Areson JG, Nelson HS. Safety and efficacy of oral immunotherapy with standardized cat extract. J Allergy Clin Immunol 1994;93: 61-7.
11. Flanagan M, Wang C, Litwin A, Michael JG. Induction of an immune response in BDF1 mice by microencapsulated allergens following oral delivery. [Abstract] J Allergy Clin Immunol 1994;93.
12. Norman PS, Lichtenstein LM, Ishizaka K. Diagnostic tests in ragweed hayfever: a comparison of direct skin tests, IgE antibody measurements and basophile histamine release. J Allergy 1973;52:210-24.
13. U.S. Pharmacopeia, USP 23 1995. The United States Pharmacopeial Convention, Inc. 12601 Twinbrook Parkway, Rockville, MD 20852. Monograph 711, p 1791-3.
14. Nelson HS, Rosioniec DM, McCall LI, Ikle D. Comparative performance of five commercial prick skin test devices. J Allergy Clin Immunol 1993; 92:750-6.
15. Norman PS. In vivo methods of study of allergy. Skin and mucosal tests, techniques, and interpretations. In: Middleton E Jr, Ellis EF, Reed CE, ed. Allergy, principles and practice, ed. 2, St Louis: Mosby-Year Book 1983.
16. Litwin A, Pesce AJ, Fischer T, et al. Regulation of the human immune response to ragweed pollen by immunotherapy. A controlled trial comparing the effect of immunosuppressive peptic fragments of short ragweed with standard treatment. Clin Exp Allergy 1991;21:457-65.
17. Peng Z, Naclerio RM, Norman PS, Adkinson NF, Jr. Quantitative IgE and IgG subclass responses during and after long-term ragweed immunotherapy. J Allergy Clin Immunol 1992;89: 519-29.
18. De Fillipi J, Yman L, Schröder H. Clinical accuracy of updated version of Phadebas RAST test. Ann Allergy 1981;45:249-55.
19. Elson C, Ealding N, Lefkowitz J. A lavage technique allowing repeated measurements of IgA antibody in mouse intestinal secretions. J Immunol Meth 1984;67:101-8.
20. Morrison DF. Applied linear statistical methods. New Jersey: Prentice Hall, 1983:407-12.
21. Möller C, Dreborg S, Lanner Å, Björkstén B. Oral immunotherapy of children with rhinoconjunctivitis due to birch pollen allergy. Allergy 1986;41: 271-9.
22. Horak F, Wheeler AW. Oral hyposensitization with enteric-coated allergens as extension therapy following a basic subcutaneous course of injections. Int Arch Allergy Appl Immunol 1987;84: 74-8.
23. Lichtenstein LM, Norman PS, Winkenwerder WL. A single year of immunotherapy for ragweed hay fever: Immunologic and clinical studies. Ann Intern Med 1971;75:663-71.
24. Patterson R, Grammer LC, Shaughnessy MA. Immunotherapy: parameters of assessment. J Allergy Clin Immunol 1983;76:394-7.
25. Stewart GE II, Lockey RF. Systemic reactions from allergen immunotherapy [Editorial]. J Allergy Clin Immunol 1992;90:567-78.
26. Creticos PS, Van Metre TE, Mardiney MR et al. Dose response of IgE and IgG antibodies during ragweed immunotherapy. J Allergy Clin Immunol 1984;73:94-104.