Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 8, 1996, Pages 829-833

  Junggren, Inga Lill ^a   Zhao, Xiaohe ^a   Sun, Xiangying ^a   Hedner, Thomas ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; LOSARTAN POTASSIUM; UNCLASSIFIED DRUG; ZD 7155;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTERIAL PRESSURE; ARTICLE; CARDIOVASCULAR EFFECT; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; HEART RATE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRESSOR RESPONSE; RAT;

EID: 0029810060     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb03983.x     Document Type: Article

References (19)

1. Bensoussan, M., Mitchell, T., Reilly, T., Timmermanns, P. B. M. W. M., Verroust, P. J., Ronco, P. M. (1993) Immunological reactivity of angiotensin II receptor antagonists: possible implications for receptor binding sites, Eur. J. Pharmacol. 247: 169-175
2. 3H)losartan receptors in isolated rat glomeruli. Eur. J. Pharmacol. 247: 193-198
3. 3H) DuP 753, a highly potent and specific radioligand for the angiotensin II-I receptor subtype. Biochem. Biophys. Res. Comm. 172: 1195-1202
4. Chiu, A. T., McCall, D. E., Price, W. A., Wong, P. C., Carini, D. J., Duncia, J. V., Wexler, R. R., Sung, E. Y., Johnson, A. L., Timmermans, P. B. M. W. M. (1990b) Nonpeptide angiotensin II receptor antagonists, VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 252: 711-718
5. Hahn, A. W., Jonas, U., Buhler, F. R., Resink, T. J. (1994) Activation of human peripheral monocytes by angiotensin II. FEBS Lett. 347: 178-180
6. MacFadyen, R. J., Reid, J. L. (1994) Angiotensin receptor antagonists as a treatment for hypertension. J. Hypertension 12: 1333-1338
7. Oldham, A. A., Allott, C. F., Major, J. S., Pearce, R. J., Roberts, D. A., Russell, S. T. (1993) Zeneca ZD 7155. A novel, potent and orally-effective angiotensin II receptor antagonist. Br. J. Pharmacol. 109(S): 136P
8. Regoli, D. (1979) Receptors for angiotensin: a critical analysis. Can. J. Physiol. Pharmacol. 57: 129-139
9. Regoli. D., Park, W. K. (1972) The pressor and myotropic effects and the antagonistic properties of several analogs of angiotensin II. Can. J. Physiol. Pharmacol. 50: 99-112
10. Rhaleb, N.-E., Rouissi, N., Nantel, F., D'Orleans-Juste, P., Regoli, D. (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17: 480-484
11. Siegl, P. K. S. (1993) Discovery of losartan, the first specific nonpeptide angiotensin II receptor antagonist. J. Hypertension 11 (Suppl 3): S19-22
12. Smith, R. D., Chiu, A. T., Wong, P. C., Herblin, W. F., Timmermanns, P. B. M. W. M. (1992) Pharmacology of nonpeptide angiotensin II receptor antagonists. Ann. Rev. Pharmacol. Toxicol. 32: 135-165
13. Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., Herblin, W. F. (1991) Nonpeptide angiotensin II receptor antagonists. Trends Pharmacol. Sci. 12: 55-62
14. Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A. M., Smith, R. D. (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 45: 205-251
15. Ujhelyi, M. R., Fergusson, R. K., Vlasses, P. H. (1989) Angiotensin-converting enzyme inhibitors; mechanistic controversies. Pharmacotherapy 9: 351-362
16. Widdop, R. E., Gardiner, K. M., Kemp, P. A., Bennett, T. (1992) Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT-receptor antagonists given after the AT1-receptor antagonist EXP 3174. Br. J. Pharmacol. 107: 873-880
17. Wong, P. C., Price, W. A., Chiu, A. T. (1990) Nonpeptide angiotensin II receptor antagonists. Hypertension 15: 823-834
18. Wong, P. C., Chiu, A. T., Duncia, J. V., Herblin, W. F., Smith, R. D., Timmermanns, P. B. M. W. M. (1992) Angiotensin II receptor antagonists and receptor subtypes. Trends Endocrinol. Metab. 3: 211-217
19. Zusman, R. M. (1987) Effects of converting enzyme inhibitors on the renin angiotensin aldosterone, bradykinin, and arachidonic acid-prostaglandin systems; correlation of chemical structure and biological activity. Am. J. Kidney Dis. 10 (suppl): 13-23