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0028592664
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Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects
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Bagshawe KD, Sharma SK, Springer CJ and Rogers GT: Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects. Ann Oncol 5: 879-891, 1994.
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Bagshawe, K.D.1
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Rogers, G.T.4
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0029095503
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Regressions and cures of melanoma xenografts following/treatment with monoclonal antibody ß-lactamase conjugates in combination with anticancer prodrugs
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Kerr DE, Schreiber GJ, Vrudhula VM, Svensson HP, Hellstrom I, Hellstrom KE and Senter PD: Regressions and cures of melanoma xenografts following/treatment with monoclonal antibody ß-lactamase conjugates in combination with anticancer prodrugs. Cancer Res 55: 3558-3563, 1995.
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0028848101
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Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs
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Blakey DC, Davies DH, Dowell RI, East SJ, Burke PJ, Sharma SK, Springer CJ, Mauger AB and Melton RG: Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs. Br J Cancer 72: 1083-1088, 1995.
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Blakey, D.C.1
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Melton, R.G.9
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0029019242
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In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody ß-lactamase conjugates
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Svensson HP, Vrudhula VM, Emswiler JE, MacMaster JF, Cosand WL, Senter PD and Wallace PM: In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody ß-lactamase conjugates. Cancer Res 55: 2357-2365, 1995.
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0028335819
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Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
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Wallace PM, MacMaster JF, Smith VF, Kerr DE, Senter PD and Cosand WL: Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res 54: 2719-2723, 1994.
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0027942213
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Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbR-2 p185
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Eccles SA, Court WJ, Box GA, Dean CJ, Melton RG and Springer CJ: Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbR-2 p185. Cancer Res 54: 5171-5177, 1994.
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0025186181
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Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/anti-alkaline phosphatase monoclonal antibody
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Sahin U, Hartmann F, Senter P, Pohl C, Engert A, Diehl V and Pfreundschuh M: Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/anti-alkaline phosphatase monoclonal antibody. Cancer Res 50: 6944-6948, 1990.
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New mustard prodrugs for antibody-directed enzyme prodrug therapy (ADEPT): Alternative to the amide link
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Dowell R, Springer CJ, Davies DH, Hadley EM, Burke PJ, Boyle FT, Melton RG, Connors TA, Blakey DC and Mauger AB: New mustard prodrugs for antibody-directed enzyme prodrug therapy (ADEPT): alternative to the amide link. J Med Chem 39: 1100-1105, 1996.
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0027390784
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Optimisation of small-scale coupling of A5B7 monoclonal antibody to carboxypeptidase G2
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Melton RG, Boyle JMB, Rogers GT, Burke PJ, Bagshawe KD and Sherwood RF: Optimisation of small-scale coupling of A5B7 monoclonal antibody to carboxypeptidase G2. J Immunol Methods 158: 49-56, 1993.
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Melton, R.G.1
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0025341331
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New colorimetric cytotoxicity assay for anti-cancer drug screening
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Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica J, Warren JT, Bokesch H, Kenney S and Boyd MR: New colorimetric cytotoxicity assay for anti-cancer drug screening. J Natl Cancer Inst 82: 1107-1112, 1990.
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0027538834
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Antitumour effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug
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Blakey DC, Valcaccia BE, East S, Wright AF, Boyle FT, Springer CJ, Burke PJ, Melton RG and Bagshawe KD: Antitumour effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug. Cell Biophys 222: 1-8, 1993.
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13
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0029621825
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Optimisation of alkylating agent prodrugs derived from phenol and aniline mustards: A new clinical candidate prodrug (ZD2767) for ADEPT
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Springer CJ, Dowell R, Burke PJ, Hadley E, Davies DH, Blakey DC, Melton RG and Niculescu-Duvaz I: Optimisation of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for ADEPT. J Med Chem 38: 5051-5065, 1996.
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Springer, C.J.1
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Hadley, E.4
Davies, D.H.5
Blakey, D.C.6
Melton, R.G.7
Niculescu-Duvaz, I.8
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