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Volumn 9, Issue 3, 1996, Pages 567-570

Antibody-directed enzyme prodrug therapy (ADEPT): Evidence for a bystander effect in vitro

Author keywords

ADEPT; bystander effect; prodrug

Indexed keywords

CARBOXYPEPTIDASE G2; IMMUNOGLOBULIN F(AB')2 FRAGMENT;

EID: 0029810013     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (13)
  • 1
    • 0028592664 scopus 로고
    • Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects
    • Bagshawe KD, Sharma SK, Springer CJ and Rogers GT: Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects. Ann Oncol 5: 879-891, 1994.
    • (1994) Ann Oncol , vol.5 , pp. 879-891
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.J.3    Rogers, G.T.4
  • 2
    • 0029095503 scopus 로고
    • Regressions and cures of melanoma xenografts following/treatment with monoclonal antibody ß-lactamase conjugates in combination with anticancer prodrugs
    • Kerr DE, Schreiber GJ, Vrudhula VM, Svensson HP, Hellstrom I, Hellstrom KE and Senter PD: Regressions and cures of melanoma xenografts following/treatment with monoclonal antibody ß-lactamase conjugates in combination with anticancer prodrugs. Cancer Res 55: 3558-3563, 1995.
    • (1995) Cancer Res , vol.55 , pp. 3558-3563
    • Kerr, D.E.1    Schreiber, G.J.2    Vrudhula, V.M.3    Svensson, H.P.4    Hellstrom, I.5    Hellstrom, K.E.6    Senter, P.D.7
  • 4
  • 5
    • 0028335819 scopus 로고
    • Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
    • Wallace PM, MacMaster JF, Smith VF, Kerr DE, Senter PD and Cosand WL: Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res 54: 2719-2723, 1994.
    • (1994) Cancer Res , vol.54 , pp. 2719-2723
    • Wallace, P.M.1    MacMaster, J.F.2    Smith, V.F.3    Kerr, D.E.4    Senter, P.D.5    Cosand, W.L.6
  • 6
    • 0027942213 scopus 로고
    • Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbR-2 p185
    • Eccles SA, Court WJ, Box GA, Dean CJ, Melton RG and Springer CJ: Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbR-2 p185. Cancer Res 54: 5171-5177, 1994.
    • (1994) Cancer Res , vol.54 , pp. 5171-5177
    • Eccles, S.A.1    Court, W.J.2    Box, G.A.3    Dean, C.J.4    Melton, R.G.5    Springer, C.J.6
  • 7
    • 0002726158 scopus 로고
    • Antibody-directed enzyme prodrug therapy: A pilot scale clinical trial
    • Bagshawe KD, Sharma SK, Springer CJ and Antoniw P: Antibody-directed enzyme prodrug therapy: a pilot scale clinical trial. Tumor Targeting 1: 17-29, 1995.
    • (1995) Tumor Targeting , vol.1 , pp. 17-29
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.J.3    Antoniw, P.4
  • 8
    • 0025186181 scopus 로고
    • Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/anti-alkaline phosphatase monoclonal antibody
    • Sahin U, Hartmann F, Senter P, Pohl C, Engert A, Diehl V and Pfreundschuh M: Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/anti-alkaline phosphatase monoclonal antibody. Cancer Res 50: 6944-6948, 1990.
    • (1990) Cancer Res , vol.50 , pp. 6944-6948
    • Sahin, U.1    Hartmann, F.2    Senter, P.3    Pohl, C.4    Engert, A.5    Diehl, V.6    Pfreundschuh, M.7
  • 13
    • 0029621825 scopus 로고    scopus 로고
    • Optimisation of alkylating agent prodrugs derived from phenol and aniline mustards: A new clinical candidate prodrug (ZD2767) for ADEPT
    • Springer CJ, Dowell R, Burke PJ, Hadley E, Davies DH, Blakey DC, Melton RG and Niculescu-Duvaz I: Optimisation of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for ADEPT. J Med Chem 38: 5051-5065, 1996.
    • (1996) J Med Chem , vol.38 , pp. 5051-5065
    • Springer, C.J.1    Dowell, R.2    Burke, P.J.3    Hadley, E.4    Davies, D.H.5    Blakey, D.C.6    Melton, R.G.7    Niculescu-Duvaz, I.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.