The effect of 5-HT and selective 5-HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro

British Journal of Pharmacology

Volumn 119, Issue 3, 1996, Pages 519-526

  Albert, Anthony P ^a   Spyer, K Michael ^a   Brooks, Penelope A ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

5 HT; 5 HT(2A) receptor subtype; Dorsal vagal preganglionic neurones; Potassium channels; Whole cell patch clamp recording

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; BEMESETRON; KETANSERIN; SEROTONIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SPIPERONE; TROPISETRON;

ANIMAL TISSUE; ARTICLE; DEPOLARIZATION; NONHUMAN; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION; VAGUS NERVE;

EID: 0029809390     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15702.x     Document Type: Article

References (43)

1. ALBERT, A.P. & BROOKS, P.A. (1994). Postsynaptic excitatory actions of 5-hydroxytryptamine on dorsal vagal motoneurones (DVMs). J. Physiol., 481, 23P.
2. 1A receptors mediate oppossing responses on membrane excitability in rat association cortex. Neuroscience, 40, 399-412.
3. 2 receptors in nucleus prepositus hypoglossi. J. Neurosci., 14, 2428-2434.
4. BOBKER, D.H. & WILLIAMS, J.T. (1991). Serotonin augments the cationic current Ih in central neurons. Neuron, 2, 1535-1540.
5. 4) receptors positively coupled to adenylate cyclase in adult guinea-pig hippocampal membranes: effects of substituted benzamide derivatives. Mol. Pharmacol., 37, 408-411.
6. BROOKS, P.A. (1991). Actions of 5-hydroxytryptamine on dorsal vagal motoneurones. J. Physiol., 438, 131P.
7. 4 receptors. Trends Neurosci., 16, 391-398.
8. ELLIOT, P. & WALLIS, D.I. (1992). Serotonin and L-norepinephrine as mediators of altered excitability in neonatal rat motoneurons studied in vitro. Neuroscience, 47, 533-544.
9. GLAUM, S.R., BROOKS, P.A., SPYER, K.M. & MILLER, R.J. (1992). 5-Hydroxytryptamine-3 receptors modulate synaptic activity in the rat nucleus tractus solitarius in vitro. Brain Res., 589, 62-68.
10. HOYER, D., CLARKE, D.E., FOZARD, J.R., HARTIG, P.R., MARTIN, G.R., MYLECHARANE, E.J., SAXENA, P.R. & HUMPHREY, P.A. (1994). VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46, 157-203.
11. JOHNSTON, A.R., MURNION, B., MCQUEEN, D.S. & DUTIA, M.B. (1993). Excitation and inhibition of rat medial vestibular nucleus neurones by 5-hydroxytryptamine. Exp. Brain Res., 93, 293-298
12. KROWICKI, Z.K. & HORNBY, P.J. (1993). Serotonin microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway. J. Pharmacol. Exp. Ther., 265, 468-476.
13. LARKMAN, P.M. & KELLY, J.S. (1991). Pharmacological characterisation or the receptor mediating 5-HT evoked motoneuronal depolarization in vitro. In Serotonin: Molecular Biology, Receptors and Functional Effects. ed. Fozard, J.R. & Saxena, P.R. pp. 310-321. Basel: Birkhauser.
14. LARKMAN, P.M. & KELLY, J.S. (1992). Ionic mechanisms mediating 5-hydroxytryptamine- and noradrenaline-evoked depolarization of adult rat facial motoneurones. J. Physiol., 456, 473-490.
15. LOEWY, A.D., FRANKLIN, M.F. & HAXHIU, M.A. (1994). CNS monoamine cell groups projecting to pancreatic vagal motor neurons: A transneuronal labelling study using pseudorabies virus. Brain Res., 638, 248-260.
16. LOEWY, A.D. & SPYER, K.M. (1992). Vagal preganglionic neurons. In Central Regulation of Autonomic Functions. ed. Loewy, A.D. & Spyer, K.M. pp. 68-87. New York: Oxford University Press.
17. MCTIGUE, D.M., ROGERS, R.C. & STEPHENS, Jr. R.L. (1992). Thyrotropin-releasing hormone analogue and serotonin interact within the dorsal vagal complex to augment gastric acid secretion. Neurosci. Lett., 144, 61-64.
18. 2 receptors to decrease potassium conductance in rat nucleus accumbens neurones. J. Physiol., 417, 1-12.
19. 2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells. Vision Res., 33, 2171-2179.
20. PEROUTKA, S.J. (1994). Molecular biology of serotonin (5-HT) receptors. Synapse, 18, 241-260.
21. PICKERING, A.E., SPANSWICK, D. & LOGAN, S.D. (1994). 5-Hydroxytryptamine evokes depolarizations and membrane potential oscillations in rat sympathetic preganglionic neurones. J. Physiol., 480, 109-121.
22. 2C receptors. Mol. Brain Res., 23, 163-178.
23. RASMUSSEN, K. & AGHAJANIAN, G.K. (1990). Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse, 5, 324-332.
24. ROGERS, R.C., KITA, H., BUTCHER, L.L. & NOVIN, D. (1980). Afferent projections to the dorsal motor nucleus of the vagus. Brain Res. Bull., 5, 365-373.
25. SAH, P. & MCLACHLAN, E.M. (1992). Potassium currents contributing to action potential repolarization and the afterpolarization in rat vagal motoneurons. J. Neurophysiol., 68, 1834-1841.
26. 1A agonists into the dorsal motor vagal nucleus produce a bradycardia in the atenolol-pretreated anaesthetized rat. Br. J. Pharmacol., 104, 466-470.
27. STEINBUSCH, H.W.M. (1981). Distribution of serotonin-immunoreactivity in the central nervous system of the rat. Cell bodies and terminals. Neuroscience, 4, 557-618.
28. 3 receptor recognition sites in the rat brain using the agonist radioligand [3H]-meta-chlorophenylbiguanide. Eur. J. Pharmacol., 243, 13-18.
29. 3 receptor mRNA. Proc. Natl. Acad. Sci. U.S.A., 90, 1430-1434.
30. THOR, K.B. & HELKE, C.J. (1987). Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat. J. Comp. Neurol., 265, 275-293.
31. 4 receptor-mediated responses in adult hippocampal neurons. J. Pharmacol. Exp. Ther., 271, 255-261.
32. TRAVAGLI, R.A. & GILLIS, R.A. (1992). Effects of thyrotropin-releasing hormone (TRH) and serotonin (5-HT) on voltage-dependent currents in motoneurones of the dorsal motor nucleus of the vagus (DMV). Gastroenterology, 103, 1392.
33. KIR, in rat dorsal motor nucleus of the vagus (DMV) neurones in vitro. J. Neurophysiol., 71, 1308-1317.
34. TRAVAGLI, R.L. & GILLIS, R.A. (1995). Effects of 5-HT alone and its interaction with TRH on neurons in rat dorsal motor nucleus of the vagus. Am. J. Physiol., 268, G292-G299.
35. TRAVAGLI, R.A., GILLIS, R.A., ROSSITER, C.D. & VICINI, S. (1991). Glutamate and GABA-mediated synaptic current in neurons of the rat dorsal motor nucleus of the vagus. Am. J. Physiol., 260, G531-G536.
36. 3 receptors. FASEB J., 6, 955.
37. 4 receptors in rat brain. Neurosci Abs., 728.3, 1856.
38. WANG, M.Y. & DUN, N.J. (1990). 5-Hydroxytryptamine responses in neonatal rat motoneurones in vitro. J. Physiol., 430, 87-103.
39. 1A receptor antagonists. Br. J. Pharmacol., 114, 160P.
40. 3 receptors mediate an excitatory action of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: an in vivo ionophoretic study. Br. J. Pharmacol., (in press).
41. WATTS, S.W. & COHEN, M.L. (1992). Characterization of the contractile serotonergic receptor in guinea-pig trachea with agonists and antagonists. J. Pharmacol. Exp. Ther., 260, 1101-1106.
42. 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol., 351, 357-373.
43. 2 1C receptor in rats. Gastroenterology, 102, A768.