What's new in ras genes? Physiological role of ras genes in signal transduction and significance of ras gene activation in tumorigenesis

Pathology Research and Practice

Volumn 192, Issue 9, 1996, Pages 883-891

  Waldmann, V ^a   Rabes, H M ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b Institute of Pathology   (Germany)

Author keywords

Carcinogenesis; Mutation; Ras genes; Signal transduction

Indexed keywords

PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL GROWTH; CELL INTERACTION; CELL METABOLISM; CELL PROLIFERATION; CYTOARCHITECTURE; GENE EXPRESSION; GENE MUTATION; HUMAN; ONCOGENE RAS; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029809315     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(96)80067-7     Document Type: Article

References (119)

1. van Aelst L, Barr M, Marcus S, Polverino A, Wigler M (1993) Complex formation between ras and raf and other protein kinases. Proc Natl Acad Sci USA 90: 6213-6217
2. Ahn N, Seger R, Krebs E (1992) The mitogen-activated protein kinase activator. Curr Op Cell Biol 4: 992-999
3. Ahuja H, Foti A, Bareli M, Cline M (1990) The pattern of mutational involvement of ras genes in human hematologic malignancies determined by DNA amplification and direct sequencing. Blood 75: 1684-1690
4. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M (1988) Most human carcinomas of the exocrine pancreas contain mutant K-ras genes. Cell 53: 549-554
5. Barbacid M (1987) Ras-genes. Annu Rev Biochem 56: 779-827
6. Basu T, Gutmann D, Fletcher J, Glover T, Collins F, Downward J (1992) Aberrant regulation of ras proteins in malignant tumour cells from typ l neurofibromatosis patients. Nature 356: 713-715
7. Bennett A, Tang T, Sugimoto S, Walsh C, Neel B (1994) Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to ras. Proc Natl Acad Sci USA 91: 7335-7339
8. Bishop J (1991) Molecular themes in oncogenesis. Cell 64 235-248
9. Blenis J (1993) Signal transduction via the MAP kinases: Proceed at your own RSK. Proc Natl Acad Sci USA 90: 5889-5892
10. Boguski M, McCormick F (1993) Proteins regulating ras and its relatives. Nature 366: 643-654
11. Bollag G, McCormick F (1992) GTPase activating proteins. Semin Cancer Biol 3: 199-208
12. Bollag G, McCormick F (1991) Differential regulation of ras-GAP and neurofibromatosis gene product activities. Nature 351: 576-578
13. Bos J, Fearon S, Hamilton S, Kern S, Verlaan-de Vries M, van Boom J, van der Eb A, Vogelstein B (1987) Prevalence of ras mutations in human colorectal cancers. Nature 327: 293-297
14. Bos J (1989) Ras oncogenes in human cancer. A review. Cancer Res 49: 4682-4689
15. Bourne H, Sanders D, McCormick F (1991) The GTPase superfamily: Conserved structure and molecular mechanism. Nature 349: 117-127
16. Bourne H, Sanders D, McCormick F (1991) The GTPase superfamily: A conserved switch for diverse cell functions. Nature 348: 125-132
17. Breivik J, Meling G, Spurkland A, Rogrium T, Gaudernack G (1994) K-ras mutation in colorectal cancer: Relations to patient age, sex and tumour location. Br J Cancer 69: 367-371
18. Burgering B, Pronk G, van Weeren P, Chardin P, Bos J (1993) CAMP antagonizes p21ras directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSOS nucleotide exchange factor. EMBO J 12: 4211-4220
19. Chandler L, Ehretsmann C, Bourgeois S (1994) A novel mechanism of Haras oncogene action: Regulation of fibronectin mRNA levels by a nuclear posrtranscriptional event. Mol Cell Biol 14: 3085-3093
20. Chaubert P, Benhattar J, Saraga E, Costa J (1994) K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. Am J Path 144: 767-775
21. Chen R, Sernecki C, Blenis J (1992) Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 22: 915-927
22. Chuang E, Barnard D, Hettich L, Zhang X, Avruch J, Marshall M (1994) Critical binding and regulatory interaction between ras and raf occur through a small, stable N-terminal domain of raf and specific ras effector residues. Mol Cell Biol 14: 5318-5325
23. Cook S, Rubinfeld B, Albert A, McCormick F (1993) RapV12 antagonizes ras-dependent activation of erk-1 and erk-2 by LPA and EGF in rat-1 fibroblasts. EMBO J 12: 3475-3485
24. Cook S, McCormick F (1993b) Inhibition of cAMP of ras-dependent activation of raf. Science 262: 1069-1072
25. Cox A, Garcia A, Westwick J, Kowalczyk J, Lewis M, Brenner D, Der C (1994) The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranyl- geranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem 269: 19203-19206
26. Crews C, Alessandrini A, Erikson R (1992) Erks: Their fifteen minutes has arrived. Cell Growth Diff 3: 135-142
27. Dawkins H, Robbins P, Smithk, Sarna M, Harvey J, Sterret G, Papadimitriou J (1993) What's new in breast cancer? Molecular perspectives of cancer development and the role of the oncogene c-erbB-2 in prognosis and therapy. Path Res Pract 189: 1233-1252
28. ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurobiromatosis. Cell 69: 265-273
29. Dekker L, Parker P (1994) Protein kinase C: A question of specifity. Trands Biochem Sci 19: 73-77
30. Deng G, Liu X, Wang J (1991) Correlation of mutations of oncogenic c-Ha-ras at codon 12 with metastasis and survival of gastric cancer patients. Oncogene Res 6: 33-38
31. ras upon T-cell activation. Nature 346: 719-723
32. Downward J (1994) The grb2/sem5 adaptor protein. FEBS Letters 338: 113-117
33. Duchesne M, Schweighoffer F, Parker F, Clerc F, Frobert Y, Thang M, Tocque B (1993) Identification of the SH domain of GAP as an essential sequence for ras-GAP-mediated signaling. Science 259: 525-528
34. Egan S, Giddings B, Brooks M, Buday L, Sizeland A, Weinberg R (1993) Association of sos ras exchange protein with grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363: 45-51
35. Egan S, Weinberg R (1993) The pathway to signal achievement. Nature 365: 781-783
36. Fabian J, Vojtek A, Cooper J, Morrison D (1994) A single amino acid change in raf-1 inhibits ras binding and alters raf-1 function. Proc Natl Acad Sci USA 91: 5982-5986
37. Fearon E (1993) K-ras gene mutations as a pathogenetic and diagnostic marker in human cancer. J Natl Cancer Inst 85: 1978-1980
38. Fearon E, Vogelstein B (1990) A genetic model for colorectal cancer. Cell 61: 759-767
39. Feig L (1994) Guanine-nucleotide exchange factors: A family of positive regulators of ras and related GTPases. Curr Opin Cell Biol 6: 204-211
40. Fernandez-Sarabia M, Bischoff J (1993) Bcl-2 associates with the ras-related protein R-ras p23. Nature 366: 274-275
41. Forrester K, Almoguera C, Han K, Grizzle W, Perucho M (1987) Detection of high incidence of K-ras oncogenes during human carcinogenesis. Nature 327: 298-303
42. Fujimori T, Satonaka K, Yamamura-Idei Y, Nagasako K, Maeda S (1994) Non-involvement of ras mutations in flat colorectal adenomas and carcinomas. Int J Cancer 57: 51-55
43. Gallego C, Gupta S, Heasley L, Qian N, Johnson G (1992) Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH3T3 and rat la cells. Proc Natl Acad Sci USA 89: 7355-7359
44. Gedde-Dahl T, Spurkland A, Fossum B, Wittinghofer A, Thorsby E, Gaudernack G (1994) T-cell epitopes encompassing the mutational hot spot position 61 of p21 ras. Promiscuity in ras peptide binding to HLA. Eur J Immunol 24: 410-414
45. Gibbs J, Oliff A, Kohl N (1994) Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77: 175-178
46. Glomset J, Gelb M, Farnsworth C (1990) Prenyl proteins in eukaryotic cells: A new type of membrane anchor. Trends Biochem Sci 15: 139-142
47. Gould M (1993) Cellular and molecular aspects of the multistage progression of mammary carcinogenesis in humans and rats. Sem Cancer Biol 4: 161-169
48. Graham S, deSolms S, Giuliani E, Kohl N, Mosser S, Oliff A, Pompliano D, Rands E, Breslin M, Deana A, Garsky V, Scholz T, Gibbs J, Smith R (1994) Pseudopeptide inhibitors of ras farnesyl-protein transferase. J Med Chem 37: 725-732
49. Gulbis B, Galand P (1993) Immunodetection of the p21 ras products in human normal and preneoplastic tissues and solid tumors: a review. Hum Pathol 24: 1271-1285
50. Gupta S, Gallego C, Johnson G, Heasley L (1992) MAP kinase is constitutively activated in gip2 and src transformed rat la fibroblasts. J Biol Chem 267: 7987-7990
51. Hesketh R (1994) The oncogene handbook, pp 378-413. Academic press, London.
52. Howe L, Leavers S, Gomez N, Nakielny S, Cohen P, Marshall C (1992) Activation of the MAP kinase pathway by the protein kinase raf. Cell 71: 335-342
53. Jacoby R, Llor X, Teng B, Davidson N, Brasitus T (1991) Mutations in the K-ras oncogene induced by 1,2-Dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. J Clin Invest 87: 624-630
54. Jamal H, Cano-Gauci D, Buick R, Filmus J (1994) Activated ras and src induce CD44 overexpression in rat intestinal epithelial cells. Oncogene 9: 417-423
55. Kaplan D, Morrison D, Wong G, McCormick F, Williams L (1990) PDGFβ-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell 61: 125-133
56. Kaziro Y, Itoh H, Kozasa T, Nakafuku M, Satoh T (1991) Structure and function of signal-transducing GTP-binding proteins. Annu Rev Biochem 60: 349-400
57. Khosravi-Far R, Der C (1994) The ras signal transduction pathway. Cancer Metastasis Rev 13: 67-89
58. Kihana T, Tsuda H, Hirota T, Shimosato Y, Sakamoto H, Terada M, Hirohashi S (1991) Point mutation of c-Ki-ras oncogene in gastric adenoma and adenocarcinoma with tubular differentiation. Jpn J Cancer Res 82: 308-314
59. Kyriakis J, App H, Zhang X, Banerjee P, Brautigan D, Rapp U, Avruch J (1992) Raf-1 activates MAP kinase-kinase. Nature 358: 417-421
60. Leevers S, Paterson H, Marshall C (1994) Requirement for ras in raf activation is overcome by targeting raf to the plasma membrane. Nature 369: 411-414
61. Lemoine N (1990) Ras oncogenes in human cancers. In: Sluyser M (Ed) Molecular Biology of Cancer Genes. Ellis Horwood, London
62. mapkk) in fibroblasts. J Cell Biol 122: 1079-1088
63. Li B, Kaplan D, Kung H, Damata T (1992) Nerve growth factor stimulation of the ras-guanine nucleotide exchange factor and GAP activities. Science 256: 1456-1459
64. Liaw G, Steingrimsson E, Pignoni F, Courey A, Lengyel J (1993) Characterization of downstream elements in a raf-1 pathway. Proc Natl Acad Sci USA 90: 858-862
65. Lin L, Wartmann M, Lin A, Knopf J, Seth A, Davis R (1993) CPLA2 is phosphorylated and activated by MAP kinase. Cell 72: 269-278
66. Lowy D, Willumsen B (1993) Function and regulation of ras. Annu Rev Biochem 62: 851-891
67. Maekawa M, Nakamura S, Hattori S (1993) Purification of a novel ras GTPase-acting protein from rat brain. J Biol Chem 268: 22948-22952
68. Maltese W (1990) Posttranslational modification of proteins by isoprenoids in mammalian cells. FASEB J 4: 3319-3328
69. Marshall C (1994) MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Develop 4: 82-89
70. Matsuda M, Hashimoto Y, Muroya K, Hasegawa H, Kurata T, Tanaka S, Nakamura S, Hattori S (1994) CRK protein binds to two guanine nucleotide-releasing proteins for the ras family and modulates nerve growth factor-induced activation of ras in PC12 cells. Mol Cell Biol 14: 5495-5500
71. McCormick F(1994) Activators and effectors of ras p21 proteins. Curr Opin Genet Develop 4: 71-76
72. McGlade J, Brunkhorst B, Anderson D, Mbmalu G, Settleman J, Dedhar S, Rodzakis-Adcock M, Chen L, Pawson T (1993) The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J 12: 3073-3081
73. Medema R, de Laat W, Martin G, McCormick F, Bos J (1992) GTPase-activating protein SH2-SH3 domains induce gene expression in a ras-dependent fashion. Mol Cell Biol 12: 3425-3430
74. ras. Mol Cell Biol 13: 155-162
75. Medema R, Bos J (1993) The role of p21ras in receptor tyrosine kinase signaling. Grit Rev Oncogenesis 4: 615-661
76. Minamoto T, Sawaguchi K, Mai M, Yamashita N, Sugimura T, Esumi H (1994) Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res 54: 2841-2844
77. Moerkerk P, Arends J, van Driel M, de Bruine A, de Goeij A, ten Kate J (1994) Type and number of Ki-ras point mutations relate to stage of human colorectal cancer. Cancer Res 54: 3376-3378
78. Molloy C, Bottaro D, Fleming T, Marshall M, Gibbs J, Aaronson S (1989) PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature 342: 711-714
79. Moodie S, Willumsen B, Weber M, Wolfman A (1992) Complexes of ras-GTP with raf-1 and mitogen-activated protein kinase. Science 260: 1658-1661
80. Pawson T, Schlessinger J (1993) SH2 and SH3 domains. Curr Biol 3: 434-442
81. Peace D, Smith J, Chen W, You S, Cosand W, Blake J, Cheever M (1994) Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide. J Exp Med 179: 473-479
82. Pelech S, Sanghera J (1992) Mitogen-activated protein kinases: Versatile transducers for cell signaling. Trends Biochem Sci 17: 233-238
83. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci P (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93-104
84. Porras A, Muszynski K, Rapp U, Santos E (1994) Dissociation between activation of raf-1 kinase and the 42 kDa mitogen-activated protein kinase/90 kDa S6 kinase (MAPK/ RSK) cascade in the insulin/ras pathway of adipocytic differentiation of 3T3I1 cells. J Biol Chem 17: 12741-12748
85. Powell S, Zilz N, Beazer-Barclay Y, Bryan T, Hamilton S, Thibodeau S, Vogelstein B, Kinzler K (1992) APC mutations occur early during colorectal tumorigenesis. Nature 359: 235-237
86. Prendergast G, Gibbs J (1993) Ras regulatory interactions: Novel targets for anti-cancer intervention? BioEssays 16: 187-191
87. Prendergast G, Davide J, deSolms S, Giuliani E, Graham S, Gibbs J, Oliff A, Kohl N (1994) Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol Cell Biol 14: 4193-4202
88. Pretlow T, Brasitus T, Fulton N, Cheyer C, Kaplan E (1994) K-ras mutations in putative preneoplastic lesions in human colon. J Natl Cancer Inst 85: 2004-2007
89. Pryer N, Wuestehuebe L, Schekman R (1992) Vesicle-mediated protein sorting. Annu Rev Biochem 61: 471-561
90. Radner H, El-Shabrawi Y, Eibl R, Brüstle O, Kenner L, Kleihues P (1993) Tumor induction by ras and myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral dose. Acta Neuropathol 86: 456-465
91. Rey I, Taylor-Harris P, van Erp H, Hall A (1994) R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation. Oncogene 9: 685-692
92. Ridley A, Hall A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389-399
93. Ridley A, Paterson H, Johnston C, Diekmann D, Hall A (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70: 401-410
94. Rochlitz C, Peter S, Willroth G, de Kant E, Lobeck H, Huhn D, Herrmann R (1992) Mutations in the ras protooncogenes are rare events in renal cell cancer. Eur J Cancer 28: 333-336
95. Rodenhuis S (1992) ras and human tumors. Semin Cancer Biol 3: 241-247
96. Rodenhuis S, Slebos R (1990) Ras oncogenes and human lung cancer. Am Rev Resp Dis 142: S27-30
97. Schlessinger J (1993) How receptor tyrosine kinases activate ras. Trends Biochem Sci 18: 273-275
98. Sinensky M, Beck L, Leonard S, Evans R (1990) Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis. J Biol Chem 265: 19937-19941
99. Spaargaren M, Martin G, McCormick F, Fernandez-Sarabia M, Bischoff J (1994) The ras-related protein R-ras interacts directly with raf-1 in a GTP-dependent manner. Biochem J 300: 303-307
100. Sukumar S, Notario V, Martin-Zanca D, Barbacid M (1983) Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature 306: 658-661
101. Sukumar S, Carney W, Barbacid M (1988) Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas. Science 240: 524-526
102. Sukumar S (1989) Ras oncogenes in chemical carcinogenesis. Curr Top Microbiol Immunol 148: 83-114
103. Suzuki Y, Orita M, Shiraishi M, Hayashi K, Sekiya M (1990) Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene 5: 1037-1043
104. Tamanoi F (1993) Inhibitors of ras farnesyltransferases. Trends Biochem Sci 18: 349-353
105. Tauchi T, Boswell H, Leibowitz D, Broxmeyer H (1994) Coupling between p210bcr-abl and she and grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway. J Exp Med 179: 167-175
106. Tobi M, Luo F, Ronai Z (1994) detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma. J Natl Cancer Inst 86: 1007-1010
107. Traverse S, Gomez N, Paterson H, Marshall C, Cohen P (1992) Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Biochem J 288: 351-355
108. Valencia A, Chardin P, Wittinghofer A, Sander C (1991) The ras protein family: Evolutionary tree and role of conserved amino acids. Biochemistry 30: 4637-4648
109. Victor T, Dutoit R, Jordaan A, Bester A, Vanhelden P (1990) No evidence for point mutations in codon 12, codon 13 and codon 61 of the ras genes in a high incidence area for esophageal and gastric cancers. Cancer Res 50: 4911-4914
110. Vojtek A, Hollenberg S, Cooper J (1993) Mammalian ras interacts directly with the serine/threonine kinase raf. Cell 74: 205-214
111. Waldmann V, Rabes H (1993) Are experimentally induced rat tumors useful tools for studying the role of activated ras genes in carcinogenesis? Abstract of the oral presentation at the symposium "Oncogenes" at the 12th meeting of the EACR, Brussels, Belgium
112. Waldmann V, Rabes H (1992) Ras gene mutation-independent tumours in the intestine of the rat by a single dose of N-Methyl-N-Nitrosourea. Int J Exp Pathol 73: 435-447
113. Waldmann V, Suchy B, Rabes H (1993) Cell proliferation and prevalence of ras gene mutations in 1,12-Dimethylbenz(a)anthracene-induced rat mammary tumors. Res Exp Med 193: 143-151
114. Williams N, Roberts T (1994) Signal transduction pathways involving the raf proto-oncogene. Cancer Metastasis Rev 13: 105-116
115. Wittinghofer A, Franken S, Scheidig A, Rensland H, Lautwein A, Pai E, Goody R (1993) Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21. In: The GTPase superfamily, pp 6-27. Wiley, Chichester, Ciba Foundation Symposium 176
116. Wu J, Dent P, Jelinek T, Wolfman A, Weber M, Sturgill T (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′, 5′-monophosphate. Science 262: 1065-1069
117. Wynford-Thomas D (1993) Molecular basis of epithelial tumorigenesis: The thyroid model. Crit Rev Oncogenesis 4: 1-23
118. Zarbl H, Sukumar S, Arthur A, Martin-Zanca D, Barbacid M (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitrososo-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315: 382-385
119. ras proteins bind to the aminoterminal regulatory domain of c-raf-1. Nature 364: 308-313