Cytokines and rheumatoid arthritis: from pathophysiology to treatment;Cytokines et polyarthrite rhumatoïde: de la physiopathologie au traitement

Immuno-analyse et biologie specialisee

Volumn 11, Issue 5, 1996, Pages 292-296

  Miossec, P ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

cytokine; destruction; inflammation; interleukin; interleukine; polyarthrite rhumato de; rheumatoid arthritis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; LEUKEMIA INHIBITORY FACTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ARTICLE; GENE THERAPY; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

EID: 0029809293     PISSN: 09232532     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2532(96)88202-0     Document Type: Review

References (21)

1. Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis
2. Differential effects of interleukins 10 and 4 on the production of interleukin-6 by blood and synovium monocytes in rheumatoid arthritis
3. Different cytokine production profiles of gd T cell clones. Relation to inflammatory arthritis
4. Interferon g inhibits interleukin-10 production by monocytes
5. Contribution of IL-1, CD 14, CD 13 in the increased IL-6 production during monocyte synoviocyte interactions
6. The balance of IL-1 receptor antagonist/IL-1β in rheumatoid synovium and its regulation by IL-4 and IL-10
7. Interleukin 4 inhibits growth factor-stimulated rheumatoid synoviocyte proliferation by blocking the early phases of the cell cycle
8. The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium
9. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor a (cA2) versus placebo in rheumatoid arthritis
10. Increased incidence of neutralizing autoantibodies against interleukin-1 alpha (IL-1 alpha) in nondestructive chronic polyarthritis.
11. Immunoregulatory role of interleukin 10 in rheumatoid arthritis
12. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus.A potential mechanism of B lymphocyte hyperactivity and autoimmunity
13. Acting on the cytokine balance to control auto-immunity and chronic inflammation
14. Interleukin 4 inhibits ex vivo production of proinflammatory cytokines and immunoglobulins by rheumatoid synovitis
15. Bypassing the antigen to control rheumatoid arthritis
16. Interleukin 4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritis
17. Heterogeneity of cytokine secretion patterns and functions of helper T cells
18. Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts
19. Human TH1 and TH2 subsets: doubt no more
20. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon?
21. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody