Effect of stobadine on gastric mucosal injury after ischaemia/reperfusion

Physiological Research

Volumn 45, Issue 5, 1996, Pages 399-403

  Mojzis J ^a   Pomfy, M ^a   Kohut A ^a   Benes L ^b   Nicak A ^a   Mirossay, L ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b Physics and Informatics   (Slovakia)

Author keywords

free radicals; gastric mucosal injury; ischaemia reperfusion; stobadine

Indexed keywords

STOBADINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG EFFECT; HISTOLOGY; ISCHEMIA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REPERFUSION INJURY; STOMACH MUCOSA INJURY;

ANIMALS; ANTI-ULCER AGENTS; CAPILLARY PERMEABILITY; CARBOLINES; GASTRIC MUCOSA; ISCHEMIA; MALE; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; REPERFUSION INJURY; STOMACH ULCER;

EID: 0029808970     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. ANDREWS F.J., MALCONTENTI C., O'BRIEN P.E.: Sequence of gastric mucosal injury following ischemia and reperfusion. Role of reactive oxygen metabolites. Dig. Dis. Sci. 37: 1356 - 1361, 1992.
2. ANDREWS F.J, MALCONTENTI-WILSON C., O'BRIEN P.E.: Polymorphonuclear leukocyte infiltration into gastric mucosa after ischemia-reperfusion. Am. J. Physiol. 266: G48 - G54, 1994.
3. BAST A., HAENEN G.R.M.M., DOELMAN C.J.A.: Oxidants and antioxidants: State of the art. Am. J. Med. 91 (Suppl 3C): 2S - 13S, 1991.
4. CLINCH K.A., VINCENZI F.F., ROHN T.T., HINDS T.R.: Stobadine protects ion pump ATPases from free radical inhibition. Proc. West. Pharmacol. Soc. 36: 209 - 214, 1993.
5. HORÁKOVÁ L., LUKOVIČ L., ŠTOLC S.: Effect of stobadine and vitamin E on the ischemie reperfused brain tissue. Pharmazie 45: 223 - 224, 1990.
6. HORÁKOVÁ L., URAZ V., ONDREJIČKOVÁ O., LUKOVIČ L., JURÁNEK I.: Effect of stobadine on brain lipid peroxidation induced by incomplete ischemia and subsequent reperfusion. Biomed. Biochim. Acta 50: 1019 - 1025, 1991.
7. KAGAN V.E, TSUCHIA M., SERBINOVÁ E., PACKER L., SIES H.: Interaction of the pyridoindole stobadine with peroxyl, superoxide and chromanoxyl radicals. Blochem. Pharmacol. 45: 393 - 400, 1993.
8. KORTHIUS R.J., GRANGER D.N., TOWNSLEY M.I., TAYLOR A.E.: The role of oxygen-derived free radicals in ischemia-induced increase in canine skeletal muscle vascular permeability. Circ. Res. 57: 599 - 609, 1985.
9. MA J.J, CHO C.H., OGLE C.V.: Portal hypertension. Its effects on gastric function and ethanol-induced gastric mucosal damage in rats. Dig. Dis. Sci. 38: 2203 - 2208, 1993.
10. MOJŽIŠ J., KOHÚT A.: The role of bioreactive forms of oxygen in gastric mucosal injury. Čs. Gastroenterol Výž 47: 275 - 280, 1993.
11. PRUIJN F.B., BAST A.: Effects of free radicals on hormonally and nonhormonally regulated calcium homeostasis in rat liver microsomes and hepatocytes. Adv. Biosci. 76: 83 - 97, 1989.
12. SANTRŮČEK M., KŘEPELKA J.: Antioxidants - potential chemotherapeutic agents. Drug Future 13: 973 - 996, 1988.
13. STEENKEN S., SUNQUIST A.R., JOVANOVIC S.V, CROCKETT R., SIES H.: Antioxidant activity of the pyridoindole stobadine. Pulse radiolytic characterization of one-electron-oxidized stobadine and quenching of singlet molecular oxygen. Chem. Res. Toxicol. 5: 355 - 360, 1992.
14. ŠTEFEK M., BENEŠ L.: Pyridoindole stobadine is a potent scavenger of hydroxyl radicals. FEBS Lett. 294: 264 - 266, 1991.
15. ŠTOLC S., BAUER V., BENEŠ L.: New antiarrhythmic drug with pyridoindole structure I. In: Abst. Symp. on Pharmacology of Cardiovascular System, Tatranské Mlynčeky, Czechoslovakia, 1982, p. 59.
16. 2 aggravated gastric mucosal injury induced by histamine in rats: possible role of increased mucosal vascular permeability. Gastroenterology 97: 1276 - 1288, 1987.
17. WELBOURN C.R.B, GOLDMAN G., PATERSON I.S., VALERI C.R, SHERPO D., HECHTMAN H.B.: Pathophysiology of ischemia reperfusion injury: central role of the neutrophil. Br. J. Surg. 78: 651 - 656, 1991.
18. ZIMMERMAN B.J., GRANGER D.N.: Oxygen free radicals and the gastrointestinal tract: role in ischemiareperfusion injury. Hepatogastroenterology 41: 337 - 342, 1994.