Relation of obesity to insulin secretion and clearance in adolescents: The Bogalusa Heart Study

International Journal of Obesity

Volumn 20, Issue 10, 1996, Pages 951-956

  Jiang, X ^a   Srinivasan, S R ^a   Berenson, G S ^a  

^a Tulane Center for Cardiovascular Health   (United States)

Author keywords

Adolescents; C peptide; Insulin clearance; Obesity

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN;

ADOLESCENT; ADULT; ARTICLE; BODY FAT; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INSULIN CLEARANCE; INSULIN RELEASE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RACE DIFFERENCE; SCHOOL CHILD;

ADOLESCENT; AFRICAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; BODY MASS INDEX; C-PEPTIDE; CHILD; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; HYPERINSULINISM; INSULIN; LOUISIANA; MALE; METABOLIC CLEARANCE RATE; OBESITY;

EID: 0029808702     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Garcia MJ, McNamara PM, Gordon T and Kannell WB Morbidity and mortality in diabetes in the Framingham population sixteen year followup study Diabetes 1974; 23: 105-111
2. Palumbo PJ et al Diabetes mellitus: Incidence, prevalence, survivorship and causes of death in Rochester, Minnesota, 1945-1970 Diabetes 1976; 25: 566-573
3. Ferrannini E et al Insulin resistance in essential hypertension N Engl J Med 1987; 317: 350-357
4. Modan M et al Hyperinsulinemia: A link between hypertension, obesity and glucose intolerance J Clin Invest 1985; 75: 809-817
5. Freedman et al Relation of body fat distribution to hyperinsulinemia in children and adolescents: The Bogalusa Heart Study Am J Clin Nutr 1987; 46: 403-410
6. Smoak CG et al Relation of obesity to clustering of cardiovascular disease risk factors in children and young adults: The Bogalusa Heart Study Am J Epidemiol 1987; 125: 364-372
7. Jiang X, Srinivasan SR, Bao W and Berenson GS Association of fasting insulin with blood pressure in young individuals: The Bogalusa Heart Study Arch Intern Med 1993; 153: 323-328
8. Jiang X et al Association of fasting insulin with serum lipids and lipoproteins in children, adolescents and young adults: The Bogalusa Heart Study Arch Intern Med 1995; 155: 190-196
9. Jiang X, Srinivasan SR, Urbina E and Berenson GS Hyperdynamic circulation and cardiovascular risk in children and adolescence: The Bogalusa Heart Study Circulation 1995; 91: 1101-1106
10. Rubenstein AH, Clark JL, Melani F and Steiner DF Secretion of proinsulin C-peptide by pancreatic beta cells and its circulation in blood Nature 1969; 224: 697-699
11. Horwitz DL et al Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood J Clin Invest 1975; 55: 1278-1283
12. Madison LL Role of insulin in the hepatic handling of glucose Arch Intern Med 1969; 123: 284-292
13. Rubenstein AH et al The metabolism of proinsulin and insulin by the liver 7 Clin Invest 1972; 51: 912-921
14. Faber OK et al Kinetics of human connecting peptide in normal and diabetic subjects J Clin Invest 1978; 62: 197-203
15. Shapiro ET et al Insulin secretion and clearance; Comparison after oral and intravenous glucose Diabetes 1987; 36: 1365-1371
16. Shuster LT et al Incretin effect is due to increased secretion and decreased clearance of insulin in normal humans Diabetes 1988; 37: 200-203
17. Katz AL and Rubenstein AH Metabolism of proinsulin, insulin and C-peptide in rat J Clin Invest 1983; 52: 1133-1121
18. Rossell R et al Reduced hepatic insulin extraction in obesity: relationship with plasma insulin levels J Clin Endocrinol Metab 1983; 56: 608-611
19. Meistas MT, Margolis S and Kowarski AA Hyperinsulinemia of obesity is due to decreased clearance of insulin Am J Physiol 1983; 245: E155-E159
20. Davidson MB, Harris MD and Rosenberg CS Inverse relationship of metabolic clearance rate of insulin to body mass index Metabolism 1987; 36: 219-222
21. Faber OK et al Decreased insulin removal contributes to hyperinsulinemia in obesity J Clin Endocrinol Metab 1981; 53: 618-621
22. Ieyoub S et al Relationship of body mass index to insulin, C-peptide and hepatic insulin clearance in females. (Abstract) Clin Res 1993; 41: 785A
23. Berenson GS et al. Cardiovascular Risk Factors in Children: The Early Natural History of Atherosclerosis and Essential Hypertension. Oxford University Press: New York, 1980, 453 pp
24. Lohman TG Assessment of body composition in children Pediatr Exerc Sci 1989; 1: 19-30
25. Tanner JM. Growth at Adolescence. 2nd edn. Blackwell: Oxford, 1962, 326 pp.
26. Osei K and Schuster DP Ethnic differences in secretion sensitivity, and hepatic extraction of insulin in black and white Americans Diabetic Med 1994; 11: 755-762
27. Stern MP The insulin resistance syndrome: The controversy is dead, long live the controversy Diabetologia 1994; 37: 956-958
28. SAS Institute Inc. SAS Users Guide: Version 6. SAS Institute Inc.: Cary, NC, 1989, vol. 1, 943 pp; vol 2, 846 pp
29. SAS Institute Inc. SAS Users Guide: Version 6. SAS Institute Inc.: Cary, NC, 1989, vol. 1, 943 pp; vol 2, 846 pp
30. Jiang X et al. Racial (black-white) differences in insulin secretion and clearance in adolescents: The Bogalusa Heart Study Pediatrics 1996; 97: 357-360
31. Savage PJ et al C-peptide and insulin secretion in Pima indians and Caucasians: constant fractional hepatic extraction over a wide range of insulin concentration and in obesity J Clin Endocrinol Metab 1979; 48: 594-598
32. Polonsky KS and Rubenstein AH C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations Diabetes 1984; 33: 486-494
33. Salvatore T et al Decreased insulin clearance as a feature of essential hypertension J Clin Endocrinol Metab 1992; 74: 144-149
34. Polonsky KS, Licinio-Paixao J and Given BD Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and Type I diabetic patients J Clin Invest 1986; 77: 98-105
35. Bruce R et al Associations between insulin sensitivity and free fatty acid and triglyceride metabolism independent of uncomplicated obesity Metabolism 1994; 43: 1275-1281
36. Mondon CE et al Abnormal insulin metabolism by specific organs from rats with spontaneous hypertension Am J Physiol 1989; 257: E491-E498
37. Lockwood DH, Hamilton CL and Livingston JN The influence of obesity and diabetes in the monkey on insulin and glucagon binding to liver membranes Endocrinology 1979; 104: 76-81
38. Svec F et al Black-white contrasts in insulin levels during pubertal development: The Bogalusa Heart Study Diabetes 1992; 41: 313-317
39. Amiel SA, Sherwin RS, Simonson DC, Lauritano AA and Tamborlane WV Impaired insulin action in puberty N Engl J Med 1986; 315: 215-219
40. Bloch CA, demons P and Sperling MA Puberty decreases insulin sensitivity J Pediatr 1987; 110: 481-487