Outcomes of neonatal screening for congenital hypothyroidism

Current Opinion in Pediatrics

Volumn 8, Issue 4, 1996, Pages 389-395

  Dattani, Mehul ^a   Brook, Charles G D ^a  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; THYROID HORMONE; THYROXINE;

BEHAVIOR DISORDER; CONGENITAL HYPOTHYROIDISM; HUMAN; INCIDENCE; INTELLECTUAL IMPAIRMENT; IODINE DEFICIENCY; LEARNING DISORDER; MOTOR DYSFUNCTION; NEWBORN; NEWBORN SCREENING; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; THYROID HORMONE BLOOD LEVEL;

EID: 0029808491     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-199608000-00016     Document Type: Review

References (62)

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53. Glorieux J, Dussault JH, Letarte J, Guyda H, Morissette J: Preliminary results on the mental development of hypothyroid infants detected by the Quebec screening programme. J Pediatr 1983, 102:19-22.
54. Heyerdahl S, Frode Kase B, Lie SO: Intellectual development in children with congenital hypothyroidism in relation to recommended thyroxine treatment. J Pediatr 1991, 118:850-857.
55. Grant DB, Smith I, Fuggle PW, Tokar S, Chapple J: Congenital hypothyroidism detected by neonatal screening: relationship between biochemical severity and early clinical features. Arch Dis Child 1992, 67:87-90.
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58. Kooistra L, Laane C, Vulsma T, Schellekens JMH, Van der Meere JJ, Kalverboer AF: Motor and cognitive development in children with congenital hypothyroidism: a long-term evaluation of the effects of neonatal treatment. J Pediatr 1994, 124:903-909.
59. Tillotson SL, Fuggle PW, Smith I, Ades AE, Grant DB: Relation between biochemical severity and intelligence in early treated congenital hypothyroidism: a threshold effect. BMJ 1994, 309:440-445. This seminal paper describes the threshold effect of the pretreatment thyroxine level on IQ. The data suggest that the severity of prenatal hypothyroxinemia will determine the degree of brain damage and hence IQ.
60. Calaciura F, Mendoria G, Distefano M, Castorina S, Fazio T, Motta RM, Sava L, Delange F, Vigneri R: Childhood IQ measurements In infants with transient congenital hypothyroidism. Clin Endocrinol 1995, 43:473-477. Global, verbal, and performance IQs were lower in nine infants with transient congenital hypothyroidism born in an area of endemic goiter than in matched control subjects living in the same environment but with normal thyroid function at birth.
61. Weber G, Siragusa V, Rondanini GF, Cerai LMP, Mora S, Colombini J, Medaglini S, Lia C, Locatelli T, Comi G, Chiumello G: Neurophysiologic studies and cognitive function In congenital hypothyroid children. Pediatr Res 1995, 37:736-740. This paper described the attention deficit and delayed nerve conduction velocity observed in infants with congenital hypothyroidism diagnosed in the prescreening era. Additionally, 47% of neonates detected by screening manifested an abnormality in at least one neurophysiologic test.
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