Novel aromatic urea derivatives with DNA-binding ability

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 10, 1996, Pages 1983-1985

  Fukutomi, Ryuuta ^a,b   Kagechika, Hiroyuki ^a   Hashimoto, Yuichi ^a   Shudo, Koichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NISSHIN SEIFUN GROUP INC   (Japan)

Author keywords

aromatic urea; calf thymus DNA; netropsin; ultrafiltration assay

Indexed keywords

1,3 BIS[5 (GLYCYLAMINO)PYRID 2 YL]UREA; CONGOCIDINE; DISTAMYCIN A; N,N' DIMETHYL N,N' BIS[(4 AMIDYLPHENYL)AMINOCARBONYL] 2.6 DIAMINOPYRIDINE; PROPAMIDINE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; BASE PAIRING; CELL PROLIFERATION; DNA DRUG COMPLEX; DNA STRUCTURE; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG POTENCY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; ULTRAFILTRATION;

EID: 0029808007     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1983     Document Type: Article

References (10)

1. Hurley L. H., J. Med. Chem., 32, 2027-2033 (1989).
2. Lown J. W., Krowicki K., Balzarini J., DeClercq E., J. Med. Chem., 29, 1210-1214 (1986); Dervan P. B., Science, 232, 464-471 (1986).
3. Lown J. W., Krowicki K., Balzarini J., DeClercq E., J. Med. Chem., 29, 1210-1214 (1986); Dervan P. B., Science, 232, 464-471 (1986).
4. Cory M., Tidwell R. R., Fairley T. A., J. Med. Chem., 35, 431-438 (1992).
5. a) Azumaya I., Kagechika H., Yamaguchi K., Shudo K., Tetrahedron, 51, 5277-5290 (1995)
6. b) Yamaguchi K., Matsumura G., Kagechika H., Azumaya I., Ito Y., Itai A., Shudo K., J. Am. Chem. Soc., 113, 5474-5475 (1991).
7. 3 (M+H) calcd. 359.1580, found 359.1585.
8. Shichita M., Shimazawa R., Nakajima O., Miziguchi H., Hashimoto Y., Iwasaki S., Biol. Pharm. Bull., 18, 637-639 (1995).
9. Kagechika H, Azumaya I, Yamaguchi K, Shudo K, Chem. Pharm. Bull., 44, 460-462 (1996).
10. Carmichael J., Degraff G. W., Gazdar F. A., Minna D. J., Mitchell B. J., Cancer Res., 47, 936-942 (1987).