Ethanol and acetaldehyde metabolism: Past, present, and future

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 8 SUPPL., 1996, Pages

  Kitson, Kathryn E ^a   Weiner, Henry ^b   Li, Ting Kai ^c  

^a MASSEY UNIVERSITY   (New Zealand)

^b PURDUE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; CYTOCHROME P450; LIVER ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ALCOHOL METABOLISM; ALCOHOLISM; CONFERENCE PAPER; ENZYME KINETICS; HUMAN; LIVER METABOLISM; OXIDATION; PRIORITY JOURNAL; STOMACH;

EID: 0029807975     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01752.x     Document Type: Conference Paper

References (77)

1. Cornell NW, Crow KE, Leadbetter MG, Veech RL: Rate-determining factors for ethanol oxidation in vivo and in isolated hepatocytes, in Li T-K, Schenker S, Lumeng L (eds): Alcohol and Nutrition. Washington, DC, U.S. Govt. Printing Office, 1979, pp 315-330
2. Lumeng L, Bosron WF, Li T-K: Correlation of ethanol elimination rates in vivo with liver alcohol dehydrogenase activity in fed, fasted, and food-restricted rats. Biochem Pharmacol 28:1547-1551, 1979
3. Rachamin G, MacDonald JA, Wahid S, Clapp JJ, Khanna JM, Israel Y: Modulation of alcohol dehydrogenase and ethanol metabolism by sex hormones in the spontaneously hypertensive rat. Biochem J 186:483-490, 1980
4. Orme-Johnson WH, Ziegler DM: Alcohol mixed function oxidase activity of mammalian liver microsomes. Biochem Biophys Res Commun 21:78-82, 1965
5. Lieber CS, Decarli LM: Hepatic microsomal ethanol oxidative system: in vitro characteristics and adaptive properties in vivo. J Biol Chem 245:2505-2512, 1970
6. Thurman RG, Ley HG, Scholz R: Hepatic microsomal ethanol oxidation. Hydroperoxide formation and the role of catalase. Eur J Biochem 25:420-428, 1972
7. Koop DR, Morgan ET, Tarr GE, Coon MJ: Purification and characterization of a unique isozyme of cytochrome P450 from liver microsomes of the rabbit. J Biol Chem 257:8472-8480, 1982
8. Lindros KO: Alcoholic liver disease: pathobiological aspects. Review, J Hepatol, suppl. 1:7-15, 1995
9. Branden C-I, Jörnvall H, Eklund H, Furugren B: Alcohol Dehydrogenases, in: The Enzymes. New York, Academic Press, 1975, pp 103-190
10. Smith M: Genetics of human alcohol and aldehyde dehydrogenases. Adv Hum Genet 15:249-290, 1986
11. Ehrig T, Bosron WF, Li T-K: Alcohol and aldehyde dehydrogenase. Alcohol Alcohol 25:105-116, 1990
12. Jörnvall H, VonVahr-Lindstrom H. Höög JO: Alcohol dehydrogenases-structure, in Crow KE, Batt RD (eds): Human Metabolism of Alcohol: Volume II Regulation, Enzymology, and Metabolism of Ethanol. Boca Raton, FL, CRC Press Inc., 1989, pp 43-64
13. Bosron WF, Ehrig T, Li T-K: Genetic factors in alcohol metabolism and alcoholism. Semin Liver Dis 13:126-135, 1993
14. Lieber CS, Gentry RT, Baraona E: First pass metabolism of ethanol. Alcohol Alcohol, (suppl) 2:163-169, 1994
15. Yuki T, Thurman RG: The swift increase in alcohol metabolism. Time course for the increase in hepatic oxygen uptake and the involvement of glycolysis. Biochem J 186:119-126, 1980
16. Crow KE, Braggins TJ, Batt RD, Hardman MJ: Rat liver cytosolic malate dehydrogenase: Purification, kinetic properties, role in control of free cytosolic NADH concentration. J Biol Chem 257:14217-14225, 1982
17. Crow KE, Braggins TJ, Batt RD, Hardman MJ: Kinetics of malate dehydrogenase and control of rates of ethanol metabolism in rats. Pharmacol Biochem Behav 18: (suppl 1) 233-236, 1983
18. Braggins TJ, Crow KE: The effects of high ethanol doses on rates of ethanol oxidation in rats. Eur J Biochem 119:633-640, 1981
19. Stowell KM, Crow KE: The effect of acute ethanol treatment on rates of oxygen uptake, ethanol oxidation and gluconeogenesis in isolated rat hepatocytes. Biochem J 230:595-602, 1985
20. Thurman RG, Glassman EB, Handler JA, Forman DT: The swift increase in alcohol metabolism (SIAM): A commentary on the regulation of alcohol metabolism in mammals, in Crow KE, Batt RD (eds): Human Metabolism of Alcohol, Vol. II. Boca Raton, FL, CRC Press Inc., 1989, pp 17-30
21. Crow KE, Hardman MJ: Regulation of rates of ethanol metabolism, in Crow KE, Batt RD (eds): Human Metabolism of Alcohol, Vol. II. Boca Raton, FL, CRC Press Inc.,1989, pp 3-16
22. Page RA, Kitson KE, Hardman MJ: The importance of alcohol dehydrogenase in regulation of ethanol metabolism in rat liver cells. Biochem J 278:659-665, 1991
23. Edenberg HJ, Brown CJ: Regulation of human alcohol dehydrogenase genes. Pharmacogenet 2:185-196, 1992
24. Yasunami M, Chen CS, Yoshida A: A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. Proc Natl Acad Sci USA 88:7610-7614, 1991
25. Kedishvili NY, Bosron WF, Stone CL, Hurley TD, Peggs CF, Thomasson HR, Popov KM, Carr LG, Edenberg HJ, Li T-K: Expression and kinetic characterization of recombinant human stomach alcohol dehyroggenase. J Biol Chem 270:3625-3630, 1995
26. Hurley TD, Bosron WF, Stone CL, Amzel LM: Structures of three human β alcohol dehydrogenase variants: Correlations with their functional differences. J Mol Biol 239:415-429, 1994
27. Eklund H, Muller-Wille P, Horjales E, Futer O, Holmquist B, Vallee BL, Höög JO, Kaiser R, Jörnvall H: Comparison of three classes of human liver alcohol dehydrogenase: Emphasis on different substrate binding pockets. Eur J Biochem 193:303-310, 1990
28. Parés X, Cederlund E, Moreno A, Hjelmqvist L, Farrés J, Jörnvall, H: Mammalian class IV alcohol dehydrogenase (stomach alcohol dehydrogenase): Structure, origin, and correlation with enzymology. Proc Natl Acad Sci USA 91:1893-1897, 1994
29. Yang Z-N, Davis GJ, Hurley TD, Stone CL, Li T-K, Bosron WF: Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction. Alcohol Clin Exp Res 18:587-591, 1994
30. Wagner FW, Parés X, Holmquist B, Vallee BL: Physical and enzymatic properties of a class III isozyme of human liver alcohol dehydro- genase: chi-ADH. .Biochemistry 23:2193-2199, 1984
31. Thomasson HR, Beard JD, Li T-K: ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol Clin Exp Res 19:1494-1499, 1995
32. Bosron WF, Li T-K: Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to al∞hol metabolism and alcoholism. Hepatology 6:502-510, 1986
33. Yin S-J, Cheng T-C, Chang C-P, Chen Y-J, Chao Y-C, Tang H-S, Chang T-M, Wu C-W: Human stomach alcohol and aldehyde dehydrogenase (ALDH): A genetic model proposed for ALDH III isoenzymes. Biochem Genet 26:343-360, 1988
34. Burnell JC, Bosron WF: Genetic polymorphism of human liver alcohol dehydrogenase and kinetic properties of the isoenzymes, in Crow KE, Batt RD (eds): Human Metabolism of Alcohol, Vol. II. Boca Raton, FL, CRC Press Inc., 1989, pp 65-75
35. Farrés J, Moreno A, Crosas B, Peralba JM, Allali-Hassani A, Hjelmqvist L, Jörnvall H, Parés X: Alcohol dehydrogenase of class IV (σσ-ADH) from human stomach cDNA sequence and structure/function relationships. Eur J Biochem 224:549-557, 1994
36. Moreno A, Parés X: Purification and characterization of a new alcohol dehydrogenase from human stomach. J Biol Chem 266:1128-1133, 1991
37. Yin S-J, Wang M-F, Liao C-S, Chen C-M, Wu C-W: Identification of a human stomach alcohol dehydrogenase with distinctive kinetic properties. Biochem Int 22:829-835, 1990
38. Stone CL, Thomasson HR, Bosron WF, Li T-K: Purification and partial amino acid sequence of a high-activity human stomach alcohol dehydrogenase. Alcohol Clin Exp Res 17:911-918, 1993
39. Yasunami M, Chen C-S, Yoshida A: A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. Proc Natl Acad Sci USA 88:7610-7614, 1991
40. Estonius M, Danielsson O, Karlsson C, Persson H, Jörnvall H, Höög J-O: Distribution of alcohol and sorbitol dehydrogenases. Assessment of mRNA species in mammalian tissues. Eur J Biochem 215:497-503, 1993
41. Engeland K, Maret W: Extrahepatic, differential expression of four classes of human alcohol dehydrogenase. Biochem Biophys Res Commun 193:47-53, 1993
42. Salaspuro M: Helicobacter pylori alcohol dehydrogenase, in Jansson B, Jörnvall H, Rydberg U, Terenius L, Vallee BL (eds): Toward a Molecular Basis of Alcohol Use and Abuse. Bassel, Birkhäuser Verlag, 1994, pp 185-195
43. Moreno A, Parés A, Ortiz J, Enríquez J, Parés X: Alcohol dehydrogenase from human stomach. Variability in normal mucosa and effect of age, sex, ADH3 phenotype and gastric region. Alcohol Alcohol 29:663-671, 1994
44. Frezza M, di Padova C, Pozzato G, Terpin M, Baraona E, Lieber CS: High blood alcohol levels in women. The role of the decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med 332:95-99, 1990
45. Seitz HK, Egerer G, Simanowski UA, Waldherr R, Eckey R, Agarwal DP, Goedde HW, von Wartburg J-P: Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism. Gut 34:1433-1437, 1993
46. Hernández-Muñoz R, Caballería J, Baraona E, Uppal R, Greenstein R, Lieber CS: Human gastric alcohol dehydrogenase: its inhibition by H2-receptor antagonists and its effect on the bioavailability of ethanol. Alcohol Clin Exp Res 14:946-950, 1990
47. Thuluvath PJ, Wojno KJ, Yardley JH, Mezey E: Effects of Helicobacter pylori infection and gastritis on gastric alcohol dehydrogenase activity. Alcohol Clin Exp Res 18:795-798, 1994
48. Harada S, Okubo T: Investigation of alcohol dehydrogenase isozymes of biopsy gastric mucosa in Japanese. Alcohol Alcohol 28:59, 1993
49. Levitt MD, Levin DG: The critical role of the rate of ethanol absorption in the interpretation of studies purporting to demonstrate gastric metabolism of ethanol. J Pharmacol Exp Ther 269:297-304, 1994
50. Parés X, Farrés J: Alcohol and aldehyde dehydrogenases in the gastrointestinal tract, in Preedy VR, Watson RR (eds): Alcohol and the Gastrointestinal Tract, Boca Raton, FL, CRC Press Inc., 1996, pp 41-56
51. Terelius Y, Lindros KO, Albano E, Ingelman-Sundberg M: Isozyme-specificity of cytochrome P450-mediated hepatotoxicity, in Rein H, Ruckpaul K (eds): Frontiers of Biotransformation 8:186-233, 1993
52. Kunitoh S, Tanaka T, Imaoka S, Funae Y, Monna Y: Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): a specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol Alcohol, (suppl) 1B:63-68, 1993
53. Wu DF, Cederbaum AI: Presence of functionally active cytochrome P450IIE1 in the plasma membrane of rat hepatocytes. Hepatology 15:515-524, 1992
54. Hansson T, Tinberg N, Ingelman-Sundberg M, Kuhler C: Regional distribution of ethanol-inducible cytochrome P450E1 in the rat central nervous system. Neuroscience 34:451-463, 1990
55. Ingelman-Sundberg M, Johansson I, Penttilä KE, Glaumann H, Lindros KO: Centrilobular expression of ethanol-inducible cytochrome P450IIE1 in rat liver. Biochem Biophys Res Commun 157:55-60, 1988
56. Ronis MJ, Lindros KO, Ingelman-Sundberg M: The CYP2E subfamily, review in Ioannides C (ed): Cytochromes P450: Metabolic and Toxicological Aspects. Boca Raton, FL, CRC Press Inc., 1996
57. Clot P, Bellomo G, Tabone M, Arico S, Albano E: Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic liver cirrhosis. Gastroenterology 108:201-207, 1995
58. Morimoto M, Hagbjörk AL, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, Albano E, French SW: Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol 10:459-464, 1993
59. Cao QN, Tu GC, Weiner H: Mitochondria as the primary site of acetaldehyde metabolism in beef and pig liver slices. Alcohol Clin Exp Res 12:720-724, 1988
60. Feldman RI, Weiner H: Horse liver aldehyde dehydrogenase. I. Purification and characterization. J Biol Chem 247:260-266, 1972
61. Greenfield NJ, Pietruszko R: Two aldehyde dehydrogenase from human liver isolation via affinity chromatography and characterization of the isozymes. Biochem Biophys Acta 483:35-45, 1977
62. Hempel J, Nicholas H, Lindahl R: Aldehyde dehydrogenase: Widespread structural and functional diversity within a shared framework. Protein Sci 2:1890-1900, 1993
63. Yoshida A, Huang I-Y, Ikawa M: Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci USA 81:258-261, 1984
64. Farrés J, Guan KL, Weiner H: Sequence of the signal for rat liver mitochondrial aldehyde dehydrogenase. Biochem Biophys Res Commun 150:1083-1087, 1988
65. Hammen P, Waltner M, Heard T, Hahnemann B, Weiner H: The role of the positive charges in the leader sequence of mitochondrial aldehyde dehydrogenase. J Biol Chem, 1996 (in press)
66. Farrés J, Takahashi K, Cunningham SJ, Wang X, Wang TT, Weiner H: Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase: A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 269:13854-13860, 1994
67. Crabb DW, Edenberg HJ, Boston WF, Li T-K: Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH's allele is dominant. J Clin Invest 83:314-316, 1989
68. Xiao Q, Weiner H, Johnston T, Crabb DW: The aldehyde dehydrogenase A2DH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. J Clin Invest 96:2180-2186, 1995
69. Higuchi S, Matsushita S, Imazeki H, Kinoshita T, Takagi S, Kono H: Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343:741-742, 1994
70. Marshall SJ, Chambers GK: Alcohol dehydrogenase and aldehyde dehydrogenase gene variants in New Zealand alcoholic patients. Alcohol Clin Exp Res 18:58A, 1994 (abstr)
71. Neumark YD, Friedlander Y, Thomasson HR, Li T-K: Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel. Nature Genet, 1996 (submitted)
72. Mizoi Y, Yamamoto K, Ueno Y, Fukunaga T, Harada S: Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 29:707-710, 1994
73. Thomasson HR, Beard JD, Li T-K: ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol Clin Exp Res 19:1491-1499, 1995
74. Chao Y-C, Liu S-R, Chung Y-Y, Tang H-S, Hsu C-T, Li T-K, Yin S-J: Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. Hepatology 19:360-366, 1994
75. Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M: High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease. Hepatology 23:234-239, 1996
76. McCarver-May DG, Thomasson H, Martier SS, Sokol R, Li T-K: Alcohol dehydrogenase 2*3 allele protects against adverse developmental offspring outcome after intrauterine alcohol exposure. Alcohol Clin Exp Res 20:122A, 1996 (abstr)
77. Lindros KO, Badger T, Ronis M, Ingelman-Sundberg M, Koivusalo M: Phenethyl isothiocyanate, a new dietary liver aldehyde dehydrogenase inhibitor. J Pharmacol Exp Ther 275:79-83, 1995