MR spectroscopy in the evaluation of enhancing lesions in the brain in multiple sclerosis

American Journal of Neuroradiology

Volumn 17, Issue 10, 1996, Pages 1829-1836

  Hirsch, Joshua A ^a   Lenkinski, Robert E ^a   Grossman, Robert I ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Brain, magnetic resonance; Magnetic resonance, spectroscopy; Sclerosis, multiple

Indexed keywords

GADOLINIUM PENTETATE MEGLUMINE;

ARTICLE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; HUMAN; IMAGE ANALYSIS; LIPID ANALYSIS; LIPID METABOLISM; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING;

ASPARTIC ACID; BRAIN; CHOLINE; CREATININE; HUMANS; INOSITOL; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MULTIPLE SCLEROSIS;

EID: 0029807955     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Francis GS, Evans AC, Arnold DL. Neuroimaging in multiple sclerosis. Neurol Clin 1995;13:147-171
2. Miller DH, McDonald WI. Neuroimaging in multiple sclerosis. Clin Neurosci 1994;2:215-224
3. Kermode AG, Thompson AJ, Tofts P, et al. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis: pathogenetic and clinical implications. Brain 1990;113:1477-1489
4. Miller DH, Rudge P, Johnson G, et al. Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. Brain 1988; 111:927-939
5. Grossman RI, Gonzalez-Scarano F, Atlas SW, Galetta S, Silberberg DH. Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 1986;161:721-725
6. Grossman RI. Magnetization transfer in multiple sclerosis. Ann Neurol 1994;36(Suppl):S97-S99
7. Grossman RI, Gomori JM, Ramer KN, Lexa FJ, Schnall MD. Magnetization transfer: theory and clinical applications in neuroradiology. Radiographics 1994;14:279-290
8. Dousset V, Grossman RI, Ramer KN, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 1992;182:483-491 (erratum appears in Radiology 1992;183:878)
9. Kauppinen RA, Williams SR. Nuclear magnetic resonance spectroscopy studies of the brain. Prog Neurobiol 1994;44:87-118
10. Lenkinski RE, Schnall MD. MR spectroscopy and the biochemical basis of neurological disease. In: Atlas SW, ed. Magnetic Resonance Imaging of the Brain and Spine. New York, NY: Lippincott-Raven; 1995:1619-1653
11. Rothman DL. 1H NMR studies of human brain metabolism and physiology. In: Gillies RJ, ed. NMR in Physiology and Biomedicine. San Diego, Calif: Academic Press; 1994
12. Arnold DL, Matthews PM, Francis GS, O'Connor J, Antel JP. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 1992;31:235-241
13. De Stefano N, Matthews PM, Antel JP, Preul M, Francis F, Arnold DL. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995;38:901-909
14. Koopmans RA, Li DK, Zhu G, Allen PS, Penn A, Paty DW. Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products (letter). Lancet 1993;341: 631-632
15. Narayana PA, Wolinsky JS, Jackson EF, McCarthy M. Proton MR spectroscopy of gadolinium-enhanced multiple sclerosis plaques. J Magn Reson Imaging 1992;2:263-270
16. Richards TL. Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy. AJR Am J Roentgenol 1991;157:1073-1078
17. Newsholme P, Newsholme EA. Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture. Biochem J 1989;261:211-218
18. Lopez-Villegas D, Lenkinski RE, Wehrli SL, Ho WZ, Douglas SD. Lactate production by human monocytes/macrophages determined by proton MR spectroscopy. Magn Reson Med 1995;34:32-38
19. Grossman RI, Lenkinski RE, Ramer KN, Gonzalez-Scarano F, Cohen JA. MR proton spectroscopy in multiple sclerosis. AJNR Am J Neuroradiol 1992;13:1535-1543
20. Hiehle JF Jr, Grossman RI, Ramer KN, Gonzalez-Scarano F, Cohen JA. Magnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadolinium-enhanced spinecho images and nonenhanced T1-weighted images. AJNR Am J Neuroradiol 1995;16:69-77
21. Pauly J, Le Roux P, Nishimura D, Macovski A. Parameter selection for the Shinar-Le Roux excitation pulse design algorithm. IEEE Trans Med Imaging 1991;10:53-65
22. Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58
23. Adams CW, Poston RN, Buk SJ. Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis. J Neurol Sci 1989;92:291-306
24. Roser W, Hagberg G, Mader I, et al. Proton MRS of gadolinium-enhancing MS plaques and metabolic changes in normal-appearing white matter. Magn Reson Med 1995;33:811-817
25. Nesbit GM, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M. Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology 1991;180:467-474
26. Ernst T, Hennig J. Coupling effects in volume selective 1H spectroscopy of major brain metabolites. Magn Reson Med 1991;21: 82-96
27. Kauppinen RA, Palvimo J. Contribution of cytoplasmic polypeptides to the 1H NMR spectrum of developing rat cerebral cortex. Magn Reson Med 1992;25:398-407
28. Kauppinen RA, Nissinen T, Karkkainen AM, et al. Detection of thymosin beta 4 in situ in a guinea pig cerebral cortex preparation using 1H NMR spectroscopy. J Biol Chem 1992;267: 9905-9910
29. Kauppinen RA, Kokko H, Williams SR. Detection of mobile proteins by proton nuclear magnetic resonance spectroscopy in the guinea pig brain ex vivo and their partial purification. J Neurochem 1992;58:967-974
30. Kauppinen RA, Niskanen T, Hakumaki J, Williams SR. Quantitative analysis of 1H NMR detected proteins in the rat cerebral cortex in vivo and in vitro. NMR Biomed 1993;6:242-247
31. Behar KL, Rothman DL, Spencer DD, Petroff OA. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magn Reson Med 1994;32:294-302