Distribution of pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactivity in the hypothalamus and extended amygdala of the rat

Journal of Comparative Neurology

Volumn 376, Issue 2, 1996, Pages 278-294

  Piggins, Hugh D ^a,c   Stamp, Jennifer A ^a   Burns, Joan ^a   Rusak, Benjamin ^a,b   Semba, Kazue ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

bed nucleus of the stria terminalis; immunocytochemistry; neuropeptide; suprachiasmatic nucleus; vasoactive intestinal polypeptide

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; NEUROPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE;

AMYGDALOID NUCLEUS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; STRIA TERMINALIS; SUPRACHIASMATIC NUCLEUS; TISSUE DISTRIBUTION;

AMYGDALA; ANIMALS; COLCHICINE; HYPOTHALAMUS; IMMUNE SERA; IMMUNOENZYME TECHNIQUES; MALE; NEUROPEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; RATS, WISTAR; SUPRACHIASMATIC NUCLEUS; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0029807660     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19961209)376:2<278::AID-CNE9>3.0.CO;2-0     Document Type: Article

References (55)

1. Alheid, G.F., and L. Heimer (1988) New perspectives in basal forebrain organization in special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of the substantia innominata. Neuroscience 27:1-39.
2. Alheid, G.F., J.S. de Olmos, and C.A. Beltramino (1995) Amygdala and extended amygdala. In G. Paxinos (ed): The Rat Nervous System. Second Edition. New York: Academic Press, pp. 495-578.
3. Arimura, A. (1992) Pituitary adenylate cyclase activating polypeptide (PACAP): Discovery and current status of research. Regul. Peptides 37:287-303.
4. Azmitia, E.C., and M. Segal (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179 641-668.
5. Canteras, N.S., R.B. Simerly, and L.W. Swanson (1994) Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 348: 41-79.
6. Card, J.P., N. Brecha, H. Karten, and R.Y. Moore (1981) Immunocytochemical localization of vasoactive intestinal polypeptide-containing cells and processes in the suprachiasmatic nucleus of the rat. Light and electron microscope analysis. J. Neurosci. 1:1289-1303.
7. Clarke, I., D. Jessop, R. Millar, M. Morris, S. Bloom, S. Lightman, C.W. Coen, R. Lew, and I. Smith (1993) Many peptides that are present in the external zone of the median eminence are not secreted into the hypophysial portal blood of sheep. Neuroendocrinology 57:765-775.
8. Davis, M. (1992a) The role of the amygdala in fear and anxiety. Ann. Rev. Neurosci. 15:353-375.
9. Davis, M. (1992b) The role of the amygdala in fear-potentiated startle: Implications for animal models of anxiety. Trends Pharmacol. 13:25-41.
10. de Olmos, J.S., G.F. Alheid, and C.A. Beltramino (1985) Amygdala. In G. Paxinos (ed): The Rat Central Nervous System. Sydney: Academic Press, pp. 223-234.
11. Dow, R.C., J. Bennie, and G. Fink (1994) Pituitary adenylate cyclase-activating peptide-38 (PACAP-38) is released into hypophysial portal blood in the normal male and female rat. J. Endocrinol. 142:R1-R4.
12. Gottschall, P.E., I. Tatsuno, A. Miyata, and A. Arimura (1990) Characterization and distribution of binding sites for the hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide. Endocrinology 127: 272-277.
13. Grove, E.A. (1988a) Neural associations of the substantia innominata in the rat: Afferent connections. J. Comp. Neurol. 277:315-346.
14. Grove, E.A. (1988b) Efferent connections of the substantia innominata in the rat. J. Comp. Neurol. 277:347-364.
15. Haglund, L., L.W. Swanson, and C. Kohler (1984) The projection of the supramammillary nucleus to the hippocampal formation: An immunohistochemical and anterograde transport study with the lectin PHA-L in the rat. J. Comp. Neurol. 229:171-185.
16. Hannibal, J., J.D. Mikkelsen, H. Clausen, J.J. Holst, B.S. Wulff, and J. Fahrenkrug (1995) Gene expression of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat hypothalamus. Regul. Peptides 55:133-148.
17. Hashimoto, H., T. Ishihara, R. Shigemoto, K. Mori, and S. Nagata (1993) Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron 11:333-342.
18. Johnson, R.F., R.Y. Moore, and L.P. Morin (1988) Retinohypothalamic projections in the rat and hamster demonstrated using cholera toxin. Brain Res. 462:301-312.
19. Johnston, J.B. (1923) Further contributions to the study of the evolution of the forebrain. J. Comp. Neurol. 35:337-481.
20. Kivipelto, L., A. Absood, A. Arimura, F. Sundler, R. Håkanson, and P. Panula (1992a) The distribution of pituitary adenylate cyclase-activating polypeptide-like immunoreactivity is distinct from helodermin- and helospectin-like immunoreactivities in the rat brain. J. Chem. Neuroanat. 5:85-94.
21. Kivipelto, L., A. Absood, R. Håkanson, F. Sundler, and P. Panula (1992b) Helodermin- and helospectin-like immunoreactivities in the rat brain: An immunochemical and immunohistochemical study. Neuroscience 47:135-153.
22. Köves, K., A. Arimura, T.G. Görcs, and A. Somogyvári-Vigh (1991) Comparative distribution of immunoreactive pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in rat forebrain. Neuroendocrinology 54:159-169.
23. Köves, K., A. Arimura, A. Somogyvári-Vigh, S. Vigh, and J. Miller (1990) Immunohistochemical demonstration of a novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, in the ovine hypothalamus. Endocrinology 127:264-271.
24. Leonhardt, S., H. Jarry, A. Kreipe, K. Werstler, and W. Wuttke (1992) Pituitary adenylate cyclase activating polypeptide (PACAP) stimulates pituitary hormone release in male rats. Neuroendocrinol. Lett. 14:319-328.
25. Lorén, I., P.C. Emson, J. Fahrenkrug, A. Björklund, J. Alumets, R. Håkanson, and F. Sundler (1979) Distribution of vasoactive intestinal polypeptide in the rat and mouse brain. Neuroscience 4:1953-1976.
26. Masuo, Y., T. Ohtaki, Y. Masada, M. Tsuda, and M. Fujino (1992) Binding sites for pituitary adenylate cyclase activating polypeptide (PACAP): Comparison with vasoactive intestinal polypeptide (VIP) binding site localization in rat brain sections. Brain Res. 575:113-123.
27. Masuo, Y., Y. Matsumoto, F. Tokito, M. Tsuda, and M. Fujino (1993a) Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis. Brain Res. 611:207-215.
28. Masuo, Y., N. Suzuki, H. Matsumoto, F. Tokito, Y. Matsumoto, M. Tsuda, and M. Fujino (1993b) Regional distribution of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat central nervous system as determined by sandwich-immunoassay. Brain Res. 602:57-63.
29. Mikkelsen, J.D., and J. Fahrenkrug (1994) Concentrations and distribution of vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI), and peptide histidine valine (PHV) in the cerebral cortex and the suprachiasmatic nucleus of the mouse. Brain Res. 656:95-107.
30. Mikkelsen, J.D., J. Hannibal, J. Fahrenkrug, P.J. Larsen, J. Olcese, and C. McArdle (1995) Pituitary adenylate cyclase activating peptide-38 (PACAP-38), PACAP-27, and PACAP related peptide (PRP) in the rat median eminence and pituitary. J. Neuroendo. 7:47-55.
31. Miyata, A., A. Arimura, R.R. Dahl, N. Minamino, A. Uehara, L. Jiang, M.D. Culler, and D.H. Coy (1989) Isolation of a novel 38 residue hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Comm. 164:567-574.
32. Miyata, A., L. Jiang, R.D. Dahl, C. Kitada, K. Kubo, M. Fujino, N. Minamino, and A. Arimura (1990) Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP-38). Biochem. Biophys. Res. Comm. 170:643-648.
33. Moore, R.Y., J.C. Speh, and J.P. Card (1995) The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells. J. Comp. Neurol. 352:351-366.
34. Morrow, J.A., E.M. Lutz, K.M. West, G. Fink, and A.J. Harmar (1993) Molecular cloning and expression of a cDNA encoding a receptor for pituitary adenylate cyclase activating polypeptide (PACAP). FEBS 329: 99-105.
35. Murase, T., K. Kondo, H. Arima, Y. Iwasaki, M. Ito, Y. Miura, and Y. Oiso (1995) The expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in rat brain: Possible role of endogenous PACAP in vasopressin release. Neurosci. Lett. 185:103-106.
36. Okamura, H., A. Miyagawa, H. Takagi, J. Esumi, N. Yanaihara, and Y. Ibata (1994) Co-existence of PACAP and nitric oxide synthase in the rat hypothalamus. NeuroReport 5:1177-1180.
37. Osuga, Y., N. Mitsuhashi, and M. Mizuno (1992) In vivo effect of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) and on the secretion of luteinizing hormone (LH) in male rats. Endocrinol. Jpn. 39:153-156.
38. Ottersen, O.P. (1981) Afferent connections to the amygdaloid complex of the rat with some observations in the cat. III. Afferents from the lower brain stem. J. Comp. Neurol.202:335-356.
39. Paxinos, G., and C. Watson (1986) The Rat Brain in Stereotaxic Coordinates. 2nd Edition. New York: Academic Press.
40. Pisegna, J.R., and S.A. Wank (1993) Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor. Proc. Natl. Acad. Sci. USA 90:6345-6349.
41. Prasser, R.A., and M.U. Gillette (1989) The mammalian circadian clock in the suprachiasmatic nuclei is reset in vitro by cAMP. J. Neurosci. 9:1073-1081.
42. Rawlings, S.R., and M. Hezareh (1996) Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/VIP receptors: Actions on the anterior pituitary gland. Endocrine Rev. in press.
43. Rusak, B., and I. Zucker (1979) Neural regulation of circadian rhythms. Physiol. Rev. 59:449-527.
44. Schwaber, J.S., B.S. Kapp, G.A. Higgins, and P.R. Rapp (1982) Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus. J. Neurosci. 2:1424-1438.
45. Sim, L.J., and S.A. Joseph (1993) Dorsal raphe nucleus efferents: Terminations in peptidergic fields. Peptides 14:75-83.
46. Simerly, R.B. (1995) Anatomical substrates of hypothalamic integration. In G. Paxinos (ed): The Rat Nervous System, Second edition. New York: Academic Press, pp. 353-376.
47. Spengler, D., C. Waeber, C. Pantaloni, F. Holsboer, J. Bockaert, P.H. Seeburg, and L. Journot (1993) Differential signal transduction of five splice variants of the PACAP receptor. Nature 365:170-175.
48. Stefanini, M., C. de Martino, and L. Zamboni (1967) Fixation of ejaculated spermatozoa for electron microscopy. Nature 216:173-174.
49. Swanson, L.W. (1987) The hypothalamus. In A. Björklund, T. Hokfelt, and L.W. Swanson (eds): Handbook of Chemical Neuroanatomy, vol. 5, Integrated Systems of the CNS, part I. Hypothalamus, Hippocampus, Amygdala, and Retina. New York: Elsevier, pp. 1-227.
50. Swanson, L.W. (1992) Brain Maps: The Structure of the Brain. Amsterdam: Elsevier.
51. Tamada, Y., M. Tanaka, Y. Ichtani, H. Okamura, N. Yanaihara, and Y. Ibata (1994) Pituitary adenylate cyclase-activating polypeptide (PACAP)-like immunoreactive neuronal elements in rat hypothalamus and median eminence with special reference to morphological background of its effect on anterior pituitary-light and electron microscopic immunocytochemistry. Neurosci. Lett. 180:105-108.
52. Vertes, R.P. (1991) A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat. J. Comp. Neurol. 313:643-668.
53. Vertes, R.P. (1992) PHA-L analysis of projections from the supramammillary nucleus in the rat. J. Comp. Neurol. 326:595-622.
54. Vigh, S., A. Arimura, K. Köves, A. Somogyvári-Vigh, J. Sitton, and C.D. Fermin (1991) Immunohistochemical localization of the neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), in human and primate hypothalamus. Peptides 12:313-318.
55. Watts, A.G., and L.W. Swanson (1987) Efferent projections of the suprachiasmatic nucleus: II. Studies using retrograde transport of fluorescent dyes and simultaneous peptide immunohistochemistry in the rat. J. Comp. Neurol. 258:230-252.