Application of an improved method for the analysis of pesticides and their metabolites in the urine of farmer applicators and their families

Environment International

Volumn 22, Issue 6, 1996, Pages 661-675

  Shealy, Dana B ^a   Bonin, Michael A ^a   Wooten, Joe V ^a   Ashley, David L ^a   Needham, Larry L ^a   Bond, Andrew E ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAS CHROMATOGRAPHY; HEALTH HAZARDS; METABOLITES;

CARBARYL CHEMICAL COMPOUND; CHRONIC PESTICIDE EXPOSURE; DICAMBA CHEMICAL COMPOUND; ENZYME DIGESTION; URINE METABOLITES;

PESTICIDE EFFECTS;

AGRICULTURAL WORKER; ANALYTIC METHOD; ARTICLE; BIOLOGICAL MONITORING; DERIVATIZATION; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; OCCUPATIONAL EXPOSURE; PESTICIDE SPRAYING; POPULATION RESEARCH; PRIORITY JOURNAL; SAMPLING; URINALYSIS;

EID: 0029807504     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/S0160-4120(96)00058-X     Document Type: Article

References (38)

1. Alavanja, M.C.R.; Akland, G.; Baird, D.; Blair, A.; Bond, A.; Dosemeci, M.; Kamel, F.; Lewis, R.; Lubin, J.; Lynch, C.; McMaster, S.B.; Moore, M.; Pennybacker, M.; Ritz, L.; Rothman, N.; Rowland, A.; Sandler, D.P.; Sinha, R.; Swanson, C.; Tarone, R.; Weinberg, C.; Zahm, S.H. Cancer and noncancer risk to women in agriculture and pest control: the Agricultural Health Study. J. Occup. Med. 36 (11):1247-1250; 1994.
2. Annest, J.L.; Pirkle, J.L.; Makuc, D.; Neese, J.W.; Bayse, D.D.; Kovar, M.G. Chronological trend in blood lead levels between 1976 and 1980. N. Engl. J. Med. 308:1373-1377; 1983.
3. Ashley, D.L.; Bonin, M.A.; Cardinali, F.L.; McCraw, J.M.; Holler, J.S.; Needham, L.L.; Patterson, D.G.Jr. Determining volatile organic compounds in human blood from a large sample population by using purge and trap gas chromatography/mass spectrometry. Anal.Chem. 64:1021-1029; 1992.
4. Bond, A.E.; McMaster, S.B.; Kuchibhatla, R.K. A pilot study for measuring occupational and environmental exposures from agricultural applications of pesticides: an overview of the AHS Human Exposure Study. Measurement of Toxic and Related Air Pollutants, Research Triangle Park, NC., May 16-18; 1995. Pittsburgh, PA: Air and Waste Management Association.
5. Braun, W.H.; Blau, G.E.; Chenoweth, M.B. The metabolism/pharmacokinetics of pentachlorophenol in man, and a comparison with the rat and monkey. Toxicol. Appl. Pharmacol. 45(1): 278-285; 1978.
6. CDC (Centers for Disease Control). Veterans Health Studies: Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in U.S. Army Vietnam-era veterans. JAMA 260:1249-1254; 1988.
7. Colby, B.N.; McCaman, M.W. A comparison of calculation procedures for isotope dilution determinations using gas chromatography mass spectrometry. Biomed. Mass Spectrom. 6(6): 225-230; 1979.
8. Comer, S.W.; Staiff, D.C.; Armstrong, J.F.; Wolfe, H.R. Exposure of workers to carbaryl. Bull. Environ. Contam. Toxicol. 13 (4):385-391; 1975.
9. Draper, W.M.; Street, J.C. Applicator exposure to 2,4-D, dicamba, and a dicamba isomer. J.Environ.Sci.Health B17 (4):321-339; 1982. Frank, R.; Campbell, R.A.; Sirons, G.J. Forestry workers involved in aerial application of 2,4-dichlorophenoxyacetic acid (2,4-D): exposure and urinary excretion. Arch. Environ. Contam. Toxicol. 14:427-435; 1985.
10. Draper, W.M.; Street, J.C. Applicator exposure to 2,4-D, dicamba, and a dicamba isomer. J.Environ.Sci.Health B17 (4):321-339; 1982. Frank, R.; Campbell, R.A.; Sirons, G.J. Forestry workers involved in aerial application of 2,4-dichlorophenoxyacetic acid (2,4-D): exposure and urinary excretion. Arch. Environ. Contam. Toxicol. 14:427-435; 1985.
11. Grover, R.; Franklin, C.A.; Muir, N.I.; Cessna, A.J.; Riedel, D. Dermal exposure and urinary metabolite excretion in farmers repeatedly exposed to 2,4-D amine. Toxicol. Let. 33:73-83; 1986a.
12. Grover, R.; Cessna, A.J.; Muir, N.I.; Riedel, D.; Franklin, C.A.; Yoshida, K. Factors affecting the exposure of ground-rig applicators to 2,4-D dimethylamine salt. Arch. Environ. Contam. Toxicol. 15:677-686; 1986b.
13. Hill, R.H.Jr.; Shealy, D.B.; Head, S.L.; Williams, C.C.; Bailey, S.L.; Gregg, M.; Baker, S.E.; Needham, L.L. Determination of pesticide metabolites in human urine using isotope dilution technique and tandem mass spectrometry. J. Anal.Toxicol. 19: 1-7; 1995.
14. Hill, R.H.Jr.; Head, S.L.; Baker, S.; Rubin, C.; Bailey, S.L.; Shealy, D.B.; Needham, L.L. The use of reference range concentrations in environmental health investigations. In: Proceedings Field Applications of Biomarkers for Agrochemicals and Toxic Substances (ACS Symposium Series); 1996a. (In press) Washington, D.C.: American Chemical Society.
15. Hill, R.H.Jr.; Head, S.L.; Baker, S.; Gregg, M.; Needham, L.L. Pesticide residues in urine of adults in the United States: reference range concentrations. Environ. Res.; 1996b. (In press)
16. Hoar, S.K.; Blair, A.; Holmes, F.F.; Boysen, C.D.; Robel, R.J.; Hoover, R.; Fraumeni, J.F.Jr. Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 256(9): 1141-1147; 1986. Holler, J.S.; Fast, D.M.; Hill, R.H.Jr.; Cardinali, F.L.; Todd, G.D.; McCraw, J.M.; Bailey, S.L.; Needham, L.L. Quantification of selected herbicides and chlorinated phenols in urine by using gas chromatography/mass spectrometry/mass spectrometry. J. Anal. Toxicol. 13: 152-157; 1989.
17. Hoar, S.K.; Blair, A.; Holmes, F.F.; Boysen, C.D.; Robel, R.J.; Hoover, R.; Fraumeni, J.F.Jr. Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 256(9): 1141-1147; 1986. Holler, J.S.; Fast, D.M.; Hill, R.H.Jr.; Cardinali, F.L.; Todd, G.D.; McCraw, J.M.; Bailey, S.L.; Needham, L.L. Quantification of selected herbicides and chlorinated phenols in urine by using gas chromatography/mass spectrometry/mass spectrometry. J. Anal. Toxicol. 13: 152-157; 1989.
18. Johnson, E.S. Association between soft tissue sarcomas, malignant lymphomas, and phenoxy herbicides/chlorophenols: evidence from occupational cohort studies. Fund. Appl. Toxicol. 14: 219-234; 1990.
19. Knaak, J.B.; Tallant, M.J.; Kozbelt, S.J.; Sullivan, L.J. The metabolism of carbaryl in man, monkey, pig, and sheep. J. Agr. Food Chem. 16 (3):465-470; 1968.
20. Knopp, D.; Glass, S. Biological monitoring of 2,4-dichlorophenoxyacetic acid-exposed workers in agriculture and forestry. Int. Arch. Occup. Environ. Health 63: 329-333; 1991.
21. Knopp, D. Assessment of exposure to 2,4-dichlorophenoxyacetic acid in the chemical industry: results of a five year biological monitoring study. Occup. Environ. Med. 51: 152-159, 1994.
22. Kohli, J.D.; Khanna, R.N.; Gupta, B.N.; Dhar, M.M.; Tandon, J.S.; and Sircar, K.P. Absorption and excretion of 2,4-dichlorophenoxyacetic acid in man. Xenobiotica 4 (2):97-100; 1974.
23. Kolmodin-Hedman, B.; Erne, K. Estimation of occupational exposure to phenoxy acids. Arch. Toxicol. Suppl. 4: 318-321; 1980.
24. Kutz, F.W.; Cook, B.T.; Carter-Pokras, O.D; Brody, D.; Murphy, R.S. Selected pesticide residues and metabolites in urine from a survey of the general U.S. population. J. Toxicol. Environ. Health 37:277-291; 1992.
25. Leaback, D.H.; Walker, P.G. Studies on glucosaminidase: the fluorimetric assay of N-acetyl-β-glucosaminidase. Biochem. J. 78: 151-155; 1961.
26. Moolenaar, R.L.; Hefflin, B.J.; Ashley, D.L.; Middaugh, J.P.; Etzel, R.A. Methyl tertiary butyl ether in human blood after exposure to oxygenated fuel in Fairbanks, Alaska. Arch. Environ. Health 49 (5): 402-409; 1994.
27. Needham, L.L.; Pirkle, J.L.; Burse, V.W.; Patterson, D.G.Jr.; Holler, J.S. Case studies of relationship between external dose and internal dose. J. Exp. Anal. Environ. Epidem. Suppl. 1: 209-221; 1992.
28. Needham, L.L.; Hill, R.H. Jr; Ashley, D.L.; Pirkle, J.L.; Sampson, E.J. The Priority Toxicant Reference Range Study: Interim Report. Environ. Health Perspect. 103(3): 89-94; 1995.
29. Nigg, H.N.; Stamper, J.H. Exposure of Florida airboat aquatic weed applicators to 2,4-dichlorophenoxyacetic acid (2,4-D). Chemosphere 12(2): 209-215; 1983.
30. Pirkle, J.L.; Sampson, E.J.; Needham, L.L.; Patterson, D.G.; Ashley, D.L. Using biological monitoring to assess human exposure to priority toxicants. Environ. Health Perspect. 103(3): 45-48; 1995.
31. Rivers, J.B.; Yauger, W.L.Jr.; Klemmer, H.W. Simultaneous gas chromatographic determination of 2,4-D and dicamba in human blood and urine. J. Chromatog. 50: 334-337; 1970.
32. Shafik, T.M.; Sullivan, H.C.; Enos, H.F. A method for the determination of 1-naphthol in urine. Bull. Environ. Contam. Toxicol. 6: 34-39; 1971.
33. Shafik, T.M.; Sullivan, H.C.; Enos, H.R. Multiresidue procedure for halo- and nitrophenols. Measurement of exposure to biodegradable pesticides yielding these compounds as metabolites. J. Agr. Food Chem. 21(2): 295-298; 1973.
34. Taylor, J.K. Quality assurance of chemical measurements. Chelsea, MI: Lewis Publishers; 1987.
35. USEPA (U.S. Environmental Protection Agency). EPA's Pesticide Programs. EPA, Washington, D.C. : U.S. Departemnt of Health and Human Services; 1991: 1-23.
36. Vural, N.; Burgaz, S. A gas chromatographic method for determination of 2,4-D residues in urine after occupational exposure. Bull. Environ. Contam. Toxicol. 33: 518-524; 1984.
37. Wigle, D.T.; Semencin, R.M.; Wilkin, K. Mortality study of Canadian male farm operators: non-Hodgkin's lymphoma mortality and agricultural practices in Saskatchewan. J. Natl. Cancer Inst. 82: 575-582; 1990.
38. Zahm, S.H.; Weisenburger, D.D.; Babbitt, P.A.; Saal, R.C.; Vaught, J.B.; Cantor, K.P.; Blair, A. A case-control study of non-Hodgkin's lymphoma and the herbicides 2,4-D and C2,4-D2 in eastern Nebraska. Epidemiology 1: 349-356; 1990.