Antithrombotic effect of human recombinant tissue factor pathway inhibitor on endotoxin-induced intravascular coagulation in rats: Concerted effect with antithrombin

Thrombosis and Haemostasis

Volumn 76, Issue 4, 1996, Pages 621-626

  Kamikubo, Yu Ichi ^a   Hamuro, Tsutomu ^a   Matsuda, Jun Ichi ^a   Shinya, Noriko ^a   Miyamoto, Seiji ^a   Funatsu, Akinobu ^a   Kato, Hisao ^b  

^a Kaketsuken   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; ANTICOAGULANT AGENT; ANTITHROMBIN; BLOOD CLOTTING FACTOR 8; ENDOTOXIN; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN; RECOMBINANT PROTEIN; TISSUE FACTOR PATHWAY INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; FIBRIN FORMATION; IMMUNOHISTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; LIVER SINUSOID; LIVER VEIN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029806188     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1650632     Document Type: Article

References (23)

1. Edgington TS, Mackman N, Brand K, Ruf W. The structural biology of expression and function of tissue factor. Thromb Haemost 1991; 66: 67-79.
2. Vinazzer H. Therapeutic use of antithrombin in shock and disseminated intravascular coagulation. Semin Thromb Hemost 1989; 15: 347-52.
3. Wun TC. Tissue factor pathway inhibitor. In: Molecular Biology of Thrombosis and Hemostasis. Roberts HR, High KA (eds.). Marcel Dekker, Inc., New York 1995.
4. Day KC, Hoffman LC, Palmier MO, Kretzmer KK, Huang MD, Pyla EY, Spokas E, Broze GJ jr, Warren TG, Wun TC. Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit. Blood 1990; 76: 1538-45.
5. Creasey AA, Chang ACK, Feigen L, Wun TC, Taylor FB jr, Hinshaw LB. Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock. J Clin Invest 1993; 91: 2850-60.
6. Bregengard C, Nordfang O, Wildgoose P, Svendsen O, Hedner U, Diness V. The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits. Blood Coagul Fibrinol 1993; 4: 699-706.
7. Holst J, Lindblad B, Bergqvist D, Nordfang O, Ostergaard PB, Petersen JGL, Nielsen G, Hedner U. Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI1-161) in experimental venous thrombosis - a comparison with low molecular weight heparin. Thromb Haemost 1994; 71: 214-9.
8. Carr C, Bild GS, Chang ACK, Peer GT, Palmier MO, Frazier RB, Gustafson ME, Wun TC, Creasey AA, Hinshaw LB, Taylor FB jr, Galluppi GR. Recombinant E. coli-derived tissue factor pathway inhibitor reduces coagulopathic and lethal effects in the baboon gram-negative model of septic shock. Circ Shock 1995; 44: 126-37.
9. Palmier MO, Hall U, Reisch CM, Baldwin MK, Wilson AGE, Wun TC. Clearance of recombinant tissue factor pathway inhibitor (TFPI) in rabbits. Thromb Haemost 1992; 68: 33-6.
10. Bregengaard C, Nordfang O, Ostergaard P, Petersen JGL, Meyn G, Diness V, Svendsen O, Hedner U. Pharmacokinetics of full length and two-domain tissue factor pathway inhibitor in combination with heparin in rabbits. Thromb Haemost 1993; 70: 454-7.
11. Warshawsky I, Broze GJ jr, Schwarzt AL. The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. Proc Natl Acad Sci USA 1994; 91: 6664-8.
12. Warshawsky I, Bu G, Mast A, Saffitz JE, Broze GJ jr, Schwartz AL. The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo. J Clin Invest 1995; 95: 1773-81.
13. Narita M, Bu G, Olins GM, Higuchi DA, Herz J, Broze GJ jr, Schwartz AL. Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo. J Biol Chem 1995; 270: 24800-4.
14. 243, of the third Kunitz domain is a heparin-binding site. Biochemistry 1995; 34: 5725-35.
15. Fraker PJ, Speck JC jr. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a, 6a-diphenylglycoluril. Biochem Biophys Res Commun 1978; 80: 849-57.
16. Abumiya T, Enjyoji K, Kokawa T, Kamikubo Y, Kato H. An anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody recognized the third Kunitz domain of free-form TFPI but not lipoprotein-associated forms in plasma. J Biochem 1995; 118: 178-82.
17. Meszaros K, Aberle S, Dedrick R, Machovich R, Horwitz A, Birr C, Theofan G, Parent JB. Monocyte tissue factor induction by lipopolysaccharide (LPS): Dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein. Blood 1994; 83: 2516-25.
18. Arai M, Mochida S, Ohno A, Ogata I, Obama H, Maruyama I, Fujiwara K. Blood coagulation equilibrium in rat liver microcirculation as evaluated by endothelial cell thrombomodulin and macrophage tissue factor. Thromb Res 1995; 80: 113-23.
19. Moll T, Czyz M, Holzmuller H, Hofer-Warbinek R, Wagner E, Winkler H, Bach FH, Hofer E. Regulation of the tissue factor promoter in endothelial cells. Binding of NF-kB-, AP-1, and Sp1-like transcription factors. J Biol Chem 1995; 270: 3849-57.
20. Nakahara Y, Miyata T, Hamuro T, Funatsu A, Miyagi M, Tsunasawa S, Kato H. Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: One N- and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked is in Kunitz domain 2. Biochemistry 1996; in press.
21. Werling RW, Zacharski LR, Kisiel W, Bajaj SP, Memoli VA, Rousseau SM. Distribution of tissue factor pathway inhibitor in normal and malignant human tissues. Thromb Haemost 1993; 69: 366-9.
22. Takei A, Tashiro K, Nakagawa K, Enjyoji K, Kato H, Sueishi K. An immunohistochemical study on the localization of TFPI in tissues (Abstract in Japanese). Jpn J Thromb Haemost 1993; 4: 319.
23. Enjyoji K, Kato H, Kamikubo Y. An interaction of TFPI with human endothelial cells (Abstract in Japanese). Seikagaku 1995; 67: 674