The role of mucus in gut protection

Current Opinion in Gastroenterology

Volumn 12, Issue 6, 1996, Pages 584-590

  Lichtman, Steven N ^a   Sherman, Phil ^b   Mack, David R ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c CREIGHTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN;

INTESTINE; INTESTINE SECRETION; MUCUS; REVIEW; STOMACH;

EID: 0029806163     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-199611000-00016     Document Type: Review

References (55)

1. Gendler SJ, Spicer AP: Epithelial mucin genes. Annu Rev Physiol 1995, 57:607-634. Informative review of the known epithelial mucin genes in human and other animal species. Particular reference is made to membrane-associated MUC1 mucins.
2. Van Klinken BJ-W, Dekker J, Buller HA, Einerhand AWC: Mucin gene structure and expression: protection vs. adhesion. Am J Physiol 1995, 269:G613-G627. Informative review on human mucins with reference to the evolving concept of different classes of mucins, namely epithelial and endothelial cell- and leukocyte-associated mucins. A scholarly interpretation and discussion of emerging studies on the characteristics of the mucin genes and their products is supplied, with particular reference to molecular biology.
3. Chambers JA, Hollingsworth MA, Trezise AE, Harris A: Developmental expression of mucin genes MUC1 and MUC2. J Cell Sci 1994, 107:413-24.
4. Chang SK, Dohrman AF, Basbaum CB, Ho SB, Tsuda T, Toribara NW, Gum JR, Kim YS: Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Gastroenterology 1994, 107:28-36.
5. Ho SB, Niehans GA, Lyftogt C, Yan PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS: Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 1993, 53:641-651.
6. Sasaki M, Nakanuma Y, Terada T, Kim YS: Biliary epithelial expression of MUC1, MUC2, MUC3, and MUC5/6 apomucins during intrahepatic bile duct development and maturation. Am J Pathol 1995, 147:574-579.
7. Lan MS, Batra SK, Qi W-N, Metzgar RS, Hollingsworth MA: Cloning and sequencing of a human pancreatic tumor cDNA. J Biol Chem 1990, 265:15294-15299.
8. Bara J, Imberty A, Perez S, Imai K, Yachi A, Oriol R: A fucose residue can mask the MUC1 epitopes in normal and cancerous gastric mucosae. Int J Cancer 1993, 54:607-613.
9. Baeckstrom D, Hansson GC, Nilsson O, Johannsson C, Gendler SJ, Lindholm L: Purification and characterization of a membrane-bound and secreted mucin type glycoprotein carrying the carcinoma-associated sialyl Le A epitope on distinct core proteins. J Biol Chem 1991, 266:21537-21547.
10. Carrato C, Balague C, De Bolos C, Gonzales E, Gambus G, Planas J, Perini JM, Andreu D, Real FX: Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology 1994, 107:160-172.
11. Ho SB, Roberton AM, Shekels LL, Lyftgot CT, Niehans GA, Toribara NW: Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression. Gastroenterology 1995, 109:735-747. Demonstration of the cell- and tissue-specific nature of mucins in the stomach.
12. Klomp LWJ, Van Rens L, Strous GJ: Cloning and analysis of human mucin cDNA reveals two types of conserved cysteine-rich domains. Biochem J 1995, 308:831-838.
13. Aubert JP, Porchet N, Crepin M, Duterque-Coquillaud M, Vergnes G, Mazzuca M, Debuire B, Petitprez D, Degand P: Evidence for different human tracheo-bronchial mucin peptides deduced from nucleotide cDNA sequences. Am J Respir Cell Biol 1991, 5:178-185.
14. Nguyen VC, Aubert JP, Gross MS, Porchet N, Degand P, Frezal J: Assignment of human tracheobronchial mucin gene(s) to 11p15 and a tracheobronchial mucin-related sequence to chromosome 13. Hum Genet 1990, 86:167-172.
15. Guyonnet Duperat V, Audie J-P, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N: Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? Biochem J 1995, 305:211-219.
16. De Bolos C, Garrido M, Real FX: MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach. Gastroenterology 1995, 109:723-734.
17. Piotrowski J, Majka J, Piotrowski E, Murty VL, Gabryelewicz A, Slomiany A, Slomainay BL: Helicobacter pylori aggregating activity of gastric mucin with ulcer healing by ebrotidine. Biochem Mol Biol Int 1994, 34:875-881.
18. Kamisago S, Iwamori M, Tai T, Mitamura K, Yazaki Y, Sugano K: Role of sulfatides in adhesion of Helicobacter pylori to gastric cancer cells. Infect Immun 1996, 64:624-628.
19. Shekels LL, Lyftogt C, Kieliszewski M, Filie JD, Kozak CA, Ho SB: Mouse gastric mucin: cloning and chromosomal localization. Biochem J 1995, 311:775-785.
20. Turner BS, Bhaskar KR, Hadzopoulou-Cladaras M, Specian RD, LaMont JT: Isolation and characterization of cDNA clones encoding pig gastric mucin. Biochem J 1995, 308:89-96.
21. Meerzaman D, Charles P, Daskal E, Polymeropoulos MH, Martin BM, Rose MC: Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). J Biol Chem 1994, 269:12932-12939.
22. Forstner GG: Signal transduction, packaging and secretion of mucins. Annu Rev Physiol 1995, 57:585-605. An excellent review of intracellular signaling and mucin secretion.
23. Poulson LK, Lan F, Kristensen CS, Hobolth P, Molin S, Krogfelt KA: Spatial distribution of E. coli in the mouse large intestine inferred from rRNA in situ hybridization. Infect Immun 1994, 62:5191-5194.
24. Mack DR, Blain-Nelson PL: Disparate in vitro inhibition of adhesion of enteropathogenic E. coli RDEC-1 by mucins isolated from various regions of the intestinal tract Pediatr Res 1995, 37:75-80.
25. Smith CJ, Kaper JB, Mack DR: Intestinal mucin inhibits adhesion of human enteropathogenic E. coli to HEp-2 cells. J Pediatr Gastroenterol Nutr 1995, 21:269-276.
26. Kim YS, Gum Jr, JR: Diversity of mucin genes, structure, function and expression. Gastroenterology 1995, 109:999-1013.
27. Tytgat KMAJ, Bovelander F-J, Opdam FJM, Einerhand AWC, Buller HA, Dekker J: Synthesis of rat MUC2 in colon and its analogy with human MUC2. Biochem J 1995, 309:221-229.
28. Belley A, Keller K, Grove J, Chadee K: Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. Gastroenterology 1996, in press.
29. Cruz N, Alverez X, Specian RD, Berg RD, Deitch EA: Role of mucin, mannose and β-1 integrin receptors in E. coli translocation across Caco-2 cell monolayers. Shock 1994, 2:121-126.
30. Yolken RH, Ojeh C, Khatri IA, Sajjan U, Forstner JF: Intestinal mucin inhibits rotavirus replication in an oligosaccharide-dependent manner. J Intect Dis 1994, 169:1002-1006.
31. Varshney KC, Bridger JC, Parsons KR, Cook R, Teucher J, Hall GA: The lesions of rotavirus infection in 1- and 10-day old gnotobiotic calves. Vet Pathol 1995, 32:619-627.
32. Kubiet M, Ramphal R: Adhesion of nontypeable Hemophilus influenzae from blood and sputum to human tracheobronchial mucins and lactoferrin. Infect Immun 1995, 63:899-902. The authors put forth the interesting hypothesis that bacterial organisms may change their localization from the respiratory tract to the systemic circulation depending on adhesion properties. This concept should be studied in the intestinal tract using organisms that are known to induce sepsis.
33. Barsum W, Wilson R, Read RC, Rutman A, Todd HC, Houdret N, Roussel P, Cole PJ: Interaction of fimbriated and non-fimbriated strains of unencapsulated Haemophilus influenzae with human respiratory tract mucus in vitro. Eur Respir J 1995, 8:709-714.
34. Reddy MS, Bernstein JM, Murphy TF, Faden HS: Binding between outer membrane proteins of nontypeable H. influenza and human nasopharyngeal mucins. Infect Immun 1996, 64:1477-1479.
35. Shuter J, Hatcher VB, Lowy FD: Staphylococcus aureus binding to human nasal mucin. Infect Immun 1996, 64:310-318.
36. Davies J, Carlstedt I, Nilsson A-K, Kakkansson A, Sabharwal H, van Alphen L, van Ham M, Svanborg C: Binding of Hemophilus influenzae to purified mucins from the human respiratory tract. Infect Immun 1995, 63:2485-2492.
37. Chadee K, Meerovitch E: The pathology of experimentally induced cecal amebiasis in gerbils. Am J Pathol 1985, 119:485-494.
38. Chadee K, Keller K, Forstner J, Inees DJ, Ravdin JI: Mucin and non-mucin secretagogue activity of Entamoeba histolytica and cholera toxin in rat colon. Gastroenterology 1991, 100:986-997.
39. Belley A, Chadee K: Eicosanoid production by parasites: from pathogenesis to immunomodulation? Parasitol Today 1995, 11:327-333.
40. Gottke M, Chadee K: Exogenous nitric oxide stimulates mucin secretion from LS174T colonic adenocarcinoma cells. Inflamm Res 1996, 45:209-212.
41. Levine S, Larivee P, Logun C, Angus CW, Ognibene FP, Shelhamer JH: TNFα induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells. Am J Respir Cell Mol Biol 1995, 12:196-204.
42. Fischer BM, Krunkosky TM, Wright DT, Dolan-O'Keefe M, Adler KB: TNFα stimulates mucin secretion and gene expression in airway epithelium in vitro. Chest 1995, 107:133S-135S.
43. Jarry A, Merlin D, Velcich A, Hopfer U, Augenlicht LH, Laboisse CL: Interferon-γ modulates cAMP-induced mucin exocytosis without affecting mucin gene expression in a human colonic goblet cell line. Eur J Pharmacol 1994, 267:95-103.
44. Moore BA, Sharkey KA, Mantle M: Role of 5-HT in cholera toxin induced mucin secretion in the rat small intestine. Am J Physiol 1996, 270:G1001-G1009.
45. Steiger D, Hotchkiss J, Bajaj L, Harkema J, Basbaum C: Concurrent increases in the storage and release of mucin-like molecules by rat airway epithelial cells in response to bacterial endotoxin. Am J Respir Cell Mol Biol 1995, 12:307-314.
46. Finnie IA, Dwarakanath D, Taylor BA, Rhodes JM: Colonic mucin synthesis is increased by sodium butyrate. Gut 1995, 36:93-99.
47. Sakata T, Setoyama H: Local stimulatory effect of short-chain fatty acids on the mucus release from the hindgut mucosa of rats. Comp Biochem Physiol A 1995, 111:429-432.
48. McCool DJ, Forstner JF, Forstner GG: Regulated and unregulated pathways for MUC2 mucin secretion in human colonic LS180 adenocarcinoma cells are distinct. Biochem J 1995, 312:125-133.
49. Kuver R, Ramesh N, Lau S, Savard C, Lee SP, Osborne WRA: Constitutive mucin secretion linked to CFTR expression. Biochem Biophys Res Comm 1994, 203:1457-1462.
50. Dahiya R, Kwak KS, Ho SB, Yoon WH, Kim YS: Cystic fibrosis and pancreatic cancer cells synthesize and secrete MUC1 type mucin gene product. Biochem Mol Biol Int 1995, 35:351-362.
51. Midtvedt A-C, Carlstedt-Duke B, Midtvedt T: Establishment of a mucin-degrading intestinal microflora during the first two years of human life. J Pediatr Gastroenterol Nutr 1994, 18:321-326.
52. Tsai HH, Dwarakanath AD, Hart CA, Milton JD, Rhodes JM: Increased fecal mucin sulphatase activity in ulcerative colitis: a potential target for treatment. Gut 1995, 36:570-576.
53. 14C threonine labelled mucin substrate. Gut 1995, 37:58-62.
54. Ruseler-van Emdsen JGH, van Lieshout LMC, Gosselink MJ, Marteau P: Inability of Lactobacillus casei strain GG, L. acidophilus, and Bifidobacterium bifidum to degrade intestinal mucus glycoproteins. Scand J Gastroenterol 1995, 30:675-680.
55. Fearon DT, Lockley RM: The instructive role of innate immunity in the acquired immune response. Science 1996, 272:50-54.