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Volumn 51, Issue 2, 1996, Pages 171-173

Comparison between concentrations of racemic mefloquine, its separate enantiomers and the carboxylic acid metabolite in whole blood serum and plasma

Author keywords

Acid metabolite; Blood concentrations; Carboxylic; Healthy volunteers; Mefloquine; Mefloquine enantiomers; Pharmacokinetics

Indexed keywords

DRUG METABOLITE; MEFLOQUINE;

EID: 0029806034     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050180     Document Type: Article
Times cited : (9)

References (10)
  • 1
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    • In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum
    • Basco LK, Gillotin C, Gimenez F, Farinotti R, Le Bras J (1992) In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum. Br J Clin Pharmacol 33:517-520
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 517-520
    • Basco, L.K.1    Gillotin, C.2    Gimenez, F.3    Farinotti, R.4    Le Bras, J.5
  • 2
    • 0020702160 scopus 로고
    • Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma
    • Bergqvist Y, Domeij-Nyberg B (1983) Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma. J Chromatogr 272: 137-148
    • (1983) J Chromatogr , vol.272 , pp. 137-148
    • Bergqvist, Y.1    Domeij-Nyberg, B.2
  • 3
    • 0023760634 scopus 로고
    • High performance liquid Chromatographic assay for the simultaneous monitoring of mefloquine and its acid metabolite in biological samples using protein precipitation and ion-pair extraction
    • Bergqvist Y, Hellgren U, Churchill FC (1988) High performance liquid Chromatographic assay for the simultaneous monitoring of mefloquine and its acid metabolite in biological samples using protein precipitation and ion-pair extraction. J Chromatogr 432:253-263
    • (1988) J Chromatogr , vol.432 , pp. 253-263
    • Bergqvist, Y.1    Hellgren, U.2    Churchill, F.C.3
  • 4
    • 0028351882 scopus 로고
    • High performance liquid Chromatographic determination of (SR) and (RS) enantiomers of mefloquine in plasma and capillary blood samples on paper after derivatization with (-)-1-(9-fluorenyl) ethyl chloroformate
    • Bergqvist Y, Doverskog M, Kabbani J (1994) High performance liquid Chromatographic determination of (SR) and (RS) enantiomers of mefloquine in plasma and capillary blood samples on paper after derivatization with (-)-1-(9-fluorenyl) ethyl chloroformate. J Chromatogr 652:73-81
    • (1994) J Chromatogr , vol.652 , pp. 73-81
    • Bergqvist, Y.1    Doverskog, M.2    Kabbani, J.3
  • 7
    • 0024539871 scopus 로고
    • La méfloquine se concentre-t-elle dans le globule rouge parasité?
    • Le Bras M, Ribou G, Brachet Liermain B (1989) La méfloquine se concentre-t-elle dans le globule rouge parasité? Presse Medical 18:492
    • (1989) Presse Medical , vol.18 , pp. 492
    • Le Bras, M.1    Ribou, G.2    Brachet Liermain, B.3
  • 9
    • 0016743953 scopus 로고
    • Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR30,090
    • Mu JY, Israeli ZH, Dayton PG (1975) Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR30,090. Drug Metab Dispos 3:198-210
    • (1975) Drug Metab Dispos , vol.3 , pp. 198-210
    • Mu, J.Y.1    Israeli, Z.H.2    Dayton, P.G.3
  • 10
    • 0028574295 scopus 로고
    • Comparison of capillary whole blood, venous whole blood and plasma concentrations of mefloquine, halofantrine and desbutyl-halofantrine measured by high-performance liquid chromatography
    • ter Kuile F, Teja-Isavatharm P, Edstein MD, Keeratithakul D, Dolan G, Nosten F, Phaipun L, Webster KH, White N (1992) Comparison of capillary whole blood, venous whole blood and plasma concentrations of mefloquine, halofantrine and desbutyl-halofantrine measured by high-performance liquid chromatography. Am J Trop Med 51:778-784
    • (1992) Am J Trop Med , vol.51 , pp. 778-784
    • Ter Kuile, F.1    Teja-Isavatharm, P.2    Edstein, M.D.3    Keeratithakul, D.4    Dolan, G.5    Nosten, F.6    Phaipun, L.7    Webster, K.H.8    White, N.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.