Cell cycle control and initiation of DNA replication in Saccharomyces cerevisiae

Biological Chemistry

Volumn 377, Issue 7-8, 1996, Pages 481-487

  Küntzel, Hans ^a   Schulz, Arne ^a   Ehbrecht, Ina Maria ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Cdc6; Cdk; Cyclins; ORC; S phase; Yeast

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CYCLIN DEPENDENT KINASE; CYCLINE; FUNGAL DNA; GUANOSINE TRIPHOSPHATASE;

CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; DNA REPLICATION; ENZYME REGULATION; METAPHASE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE;

CELL CYCLE; DNA REPLICATION; ENZYME ACTIVATION; PROTEIN KINASES; REPLICATION ORIGIN; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0029805784     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (74)

1. Amon, A.,Tyers, M., Futcher, B., and Nasmyth, K. (1993). Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell 74, 993-1007.
2. Amon, A., Irniger, S., and Nasmyth, K. (1994). Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell 77, 1037-1050.
3. Basco, R.D., Segal, M.D., and Reed, S.I. (1995). Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae. Mol. Cell. Biol. 15, 5030-5042.
4. Bell, S.P., and Stillman, B. (1992). ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357, 128-134.
5. Bell, S.P., Kobayashi, R., and Stillman, B. (1993). Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262, 1844-1849.
6. Bell, S.P., Mitchell, J., Leber, J., Kobayashi, R., and Stillman, B. (1995). The multidomain structure of Orc 1 p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83, 563-568.
7. Bueno, A., and Russell, P. (1992). Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division. EMBO J. 11, 2167-2176.
8. Byers, B. (1981). Cytology of the yeast life cycle. In: The Molecular Biology of the Yeast Saccharomyces, Life Cycle and Inheritance. J.N. Strathern, E.W.W. Jones and J.R. Broach, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 58-95.
9. Celniker, S.E., Sweder, K., Srienc, F., Bailey, J.E., and Campbell, J.L. (1984). Deletion mutations affecting autonomously replicating sequence ARS1 of Saccharomyces cerevisiae. Mol. Cell. Biol, 4, 2455-2466.
10. Chong, J.P.J., Thömmes, P., and Blow, J.J. (1996). The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem. Sci. 21, 102-106.
11. Cocker, J.H., Piatti, S., Santocanale, C., Nasmyth, K., and Diffley, J.F.X. (1996). An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379, 180-182.
12. Dahmann, C., Diffley, J.F.X., and Nasmyth, K. (1995). S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol. 5, 1257-1269.
13. Dalton, S., and Whitbread, L. (1995). Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast. Proc. Natl. Acad. Sci. USA 92, 2514-2518.
14. Diffley, J.F.X., and Stillman, B. (1988). Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc. Natl. Acad. Sci. USA 85, 2120-2124.
15. Diffley, J.F.X. (1992). Global regulators of chromosome function in yeast. In: Molecular Biology of Saccharomyces cerevisiae. L.A. Grivell, ed. (London: Kluwer Academic Publishers), pp. 25-33.
16. Diffley, J.F.X., and Cocker, J.H. (1992). Protein-DNA interactions at a yeast replication origin. Nature 357, 169-172.
17. Diffley, J.F.X., Cocker, J.H., Dowell, S.J., and Rowley, A. (1994). Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78, 303-316.
18. Diffley, J.F.X., Cocker, J.H., Dowell, S.J., Harwood, J., and Rowley, A. (1995). Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle. J. Cell Science, Supplement 19, 67-72.
19. Dirick, L., Böhm,T., and Nasmyth, K. (1995). Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14, 4803-4813.
20. Dowell, S.J., Romanowski, P., and Diffley, J.F.X. (1994). Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265, 1243-1246.
21. Epstein, C.B., and Cross, F.R. (1992). CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev. 6, 1695 - 1706.
22. Foiani, M., Marini, F., Gamba, D., Lucchini, G., and Plevani, P. (1994). The B subunit of the DNA polymerase α-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol. Cell Biol. 14, 923-933.
23. Forsburg, S.L., and Nurse, P. (1991). Cell cycle regulation in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Annu. Rev. Cell Biol. 7, 227-256.
24. Foss, C.A., McNally, F.J., Laurenson, P., and Rine, J. (1993). Origin recognition complex (ORC) in transcriptional silencing and DNA replication in Saccharomyces cerevisiae. Science 262, 1838-1844.
25. Ghiara, J.B., Richardson, H.E., Sugimoto, K., Henze, M., Lew, D.J., Wittenberg, C., and Reed, S.I. (1991). A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell 65, 163-174.
26. Grandin, N., and Reed, S.I. (1993). Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis. Mol. Cell. Biol. 13, 2113-2125.
27. Hartwell, L.H., Culotti, J., and Reid, B. (1970). Genetic control of the cell-division cycle in yeast, I. Detection of mutants. Proc. Natl. Acad. Sci. USA 66, 352-359.
28. Hartwell, L.H., Mortimer, R.K., Culotti, J., and Culotti, M. (1973). Genetic control of the cell division cycle in yeast. V. Genetic analysis of cdc mutants. Genetics 74, 267-286.
29. Hartwell, L.H. (1976). Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J. Mol. Biol. 104, 803-817.
30. Hartwell, L.H., and Smith, D. (1985). Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110, 381-395.
31. Hennessy, K.M., Clark, C.D., and Botstein, D. (1990). Subcellular localization of yeast CDC46 varies with the cell cycle. Genes Dev. 4, 2252-2263.
32. Hennessy, K.M., Lee, A., Chen, E., and Botstein, D. (1991). A group of interacting yeast DNA replication genes. Genes Dev. 5, 958-969.
33. Hogan, E., and Koshland, D. (1992). Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 89, 3098-3102.
34. Irniger, S., Piatti, S., Michaelis, C., and Nasmyth, K. (1995). Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81, 269-277.
35. Jackson, A.L., Pahl, P.M., Harrison, K., Rosamond, J., and Sclafani, R.A. (1993). Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell. Biol. 73, 2899-2908.
36. Kelly, T.J., Martin, G.S., Forsburg, S.L., Stephen, R.J., Russo, A., and Nurse, P. (1993). The fission yeast cdc18+ gene product couples S phase to START and mitosis. Cell 74, 371-382.
37. Koch, C., Schleiffer, A., Ammerer, G., and Nasmyth, K. (1996). Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2. Genes Dev. 10, 129-141.
38. Kühne, C., and Linder, P. (1993). A new pair of B-cyclins from Saccharomyces cerevisiae that function early in the cell cycle. EMBO J. 12, 3437-3447.
39. Küntzel, H., Rottjakob, H.-W., Schwed, A., and Zwerschke, W. (1994). START control in cyclin Saccharomyces cerevisiae cells. Progr. Nucleic Acid Res. Mol. Biol. 48, 1-28.
40. Li, J.J., and Herskowitz, I. (1993). Isolation of ORC6, a component of the yeast origin complex by a one-hybrid system. Science 262, 1870-1874.
41. Li, J.J. (1995). DNA replication. Once, and only once. Current Biol. 5, 472-475.
42. Liang, C., Weinreich, M., and Stillman, B. (1995). ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81, 667-676.
43. Lisziewicz, J., Godany, A., Agoston, D.V., and Küntzel, H. (1988). Cloning and characterization of the Saccharomyces cerevisiae CDC6 gene. Nucleic Acids Res. 16, 11507-11520.
44. Loo, S., Fox, C.A., Rine, J., Kobayashi, R., Stillman, B., and Bell, S. (1995). The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol. Biol. Cell 6, 741-756.
45. Lydall, D., Ammerer, G., and Nasmyth, K. (1991). A new role for MCM1 in yeast: cell cycle regulation of SWI5 transcription. Genes Dev. 5, 2405-2419.
46. Maher, M., Cong, F., Kindelberger, D., Nasmyth, K., and Dalton, S. (1995). Cell cycle-regulated transcription of the CLB2 gene is dependent on Mcm1 and a ternary complex factor. Mol. Cell Biol. 75, 3129-3137.
47. Marahrens, Y., and Stillman, B. (1992). A yeast chromosomal origin of DNA replication defined by multiple functional elements. Science 255, 817-823.
48. Micklem, G., Rowley, A., Harwood, J., Nasmyth, K., and Diffley, J.F.X. (1993). Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature 366, 87-89.
49. Moll, T., Tebb, G., Surana, U., Robitsch, H., and Nasmyth, K. (1991). The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclearimport of the S. cerevisiae transcription factor SWI5. Cell 66, 743-758.
50. Nasmyth, K. (1993). Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol. 5, 166-179.
51. Oliver, S.G. (1996). From DNA sequence to biological function. Nature 379, 597-600.
52. Palmer, R.E., Hogan, E., and Koshland, D. (1990). Mitotic transmission of artificial chromosomes in cdc mutants of the yeast Saccharomyces cerevisiae. Genetics 125, 763-774.
53. Piatti, S., Lengauer, C., and Nasmyth, K. (1995). Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14, 3788-3799.
54. Pines, J. (1993). Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem. Sci. 18, 195-197.
55. Pringle, J.R., and Hartwell, L.H. (1981). The Saccharomyces cerevisiae cell cycle. In: The Molecular Biology of the Yeast Saccharomyces, Life Cycle and Inheritance. J.N. Strathern, E.W. Jones and J.R. Broach, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 97-142.
56. Rao, H., and Stillman, B, (1995). The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators. Proc. Natl. Acad. Sci. USA 92, 2224-2228.
57. Reed, S.I. (1992). The role of p34 kinases in the G1 to S-phase transition. Annu. Rev. Cell Biol. 8, 529-561.
58. Richardson, H., Lew, D.J., Henze, M., Sugimoto, K., and Reed, S.I. (1992). Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. Genes Dev. 6, 2021-2034.
59. Rowley, A., Dowell, S.J., and Diffley, J.F.X. (1994). Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges. Biochim. Biophys. Acta 1217, 239-256.
60. Rowley, A., Cocker, J.H., Harwood, J., and Diffley, J.F.X. (1995). Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. EMBO J. 14, 2631-2641.
61. Schwob, E., and Nasmyth, K. (1993). CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Sacctaromyces cerevisiae. Genes Dev. 7, 1160-1175.
62. Schwob, E., Böhm,T., Mendenhall, M.D., and Nasmyth, K. (1994). The B-type cyclin kinase inhibitor p40(SIC1) controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244.
63. Surana, U., Robitsch, H., Price, C., Schuster, T., Fitch, I., Futcher, A.B., and Nasmyth, K. (1991). The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65, 145-161.
64. Tye, B.-K. (1994). The MCM2-3-5 proteins: are they replication licensing factors? Trends Cell Biol. 4, 160-165.
65. Tyers, M., Tokiwa, G., and Futcher, B. (1993). Comparison of the S. cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12, 1955-1968.
66. Wan, J., Xu, H., and Grunstein, M. (1992). CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle. J. Biol. Chem. 267, 11274-11280.
67. Wang, T.A., and Li, J.J. (1995). Eukaryotic DNA replication. Curr. Opinion Cell Biol. 7, 414-420.
68. Weinert, T.A., Kiser, G.L., and Hartwell, L.H. (1994). Mitotic checkpoint genes in budding yeast and dependence of mitosis on DNA replication and repair. Genes Dev. 8, 652-665.
69. Whitbread, L.A., and Dalton, S. (1995). Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initiation of eukaryotic DNA replication. Gene 155, 113-117.
70. Yan, H., Gibson, S., and Tye, B.K. (1991). Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. Genes Dev. 5, 944-957.
71. Zhou, C., Huang, S.-H., and Jong, A. (1989). Molecular cloning of Saccharomyces cerevisiae CDC6 gene. J. Biol. Chem. 264, 9022-9029.
72. Zhou, C., and Jong, A. (1990). CDC6 mRNA fluctuates periodically in the yeast cell cycle. J. Biol. Chem. 265, 19904-19909.
73. Zwerschke, W. (1994). Untersuchungen zur Regulation und Funktion des CDC6-Gens aus Saccharomyces cerevisiae. Doctoral dissertation, University of Göttingen.
74. Zwerschke, W., Rottjakob, H.-W., and Küntzel, H. (1994). The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation. J. Biol. Chem. 269, 23351-23356.