Localization of sequences that influence basal and cell type-specific activity of the murine mdr2 promoter

Cell Growth and Differentiation

Volumn 7, Issue 9, 1996, Pages 1227-1237

  Yang, Chia Ping Huang ^a   Kirschner, Lawrence S ^a   Yu, Lijia ^a   Horwitz, Susan Band ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; DNA FOOTPRINTING; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE LOCATION; GENE SEQUENCE; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BINDING SITES; CELL LINE; CLONING, MOLECULAR; DNA FOOTPRINTING; DNA METHYLATION; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION; GENES, MDR; GENES, REPORTER; LIVER; LUCIFERASES; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; VINBLASTINE;

ANIMALIA; MURINAE;

EID: 0029805771     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Croop, J. M., Raymond, M., Haber, D., Devault, A., Arceci, R. J., Gros, P., and Housman, D. E. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol. Cell. Biol., 9: 1346-1350, 1989.
2. Teeter, L. D., Becker, F. F., Chisari, F. V., Li, D., and Kuo, M. T. Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Mol. Cell. Biol., 10: 5728-5735, 1990.
3. van der Bliek, A. M., Baas, F., Ten Houte de Lange, T., Kooiman, P. M., van der Velde-Koerts, T., and Borst, P. The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. EMBO J., 6: 3325-3331, 1987.
4. Chin, J. E., Soffir, R., Noonan, K. E., Choi, K., and Roninson, I. B. Structure and expression of the human MDR (P-glycoprotein) gene family. Md. Cell. Biol., 9: 3808-3820, 1989.
5. Nooter, K., and Herweijer, H. Multidrug resistance (mdr) genes in human cancer. Br. J. Cancer, 63: 663-669, 1991.
6. Sonneveld, P., Nooter, K., Burghouts, J. Th. M., Herweijer, H., Adriaansen, H. J., and van Dongen, J. J. M. High expression of the mdr3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia. Blood, 79: 1496-1500, 1992.
7. Gros, P., Raymond, M., Bell, J., and Housman, D. Cloning and characterization of a second member of the mouse mdr gene family. J. Biol. Chem., 8: 2770-2778, 1988.
8. Raymond, M., Rose, E., Housman, D. E., and Gros, P. Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol. Cell. Biol., 10: 1642-1651, 1990.
9. Buschman, E., and Gros, P. Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes. Mol. Cell. Biol., 11: 595-603, 1991.
10. Buschman, E., Arceci, R. J., Croop, J. M., Che, M., Arias, I. M., Housman, D. E., and Gros, P. mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J. Biol. Chem., 267: 18093-18099, 1992.
11. Smit, J. J. M., Schinkel, A. H., Oude Elferink, R. P. J., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., Ottenhoff, R., van der Lugt, N. M. T., van Roon, M. A., van der Valk, M. A., Offerhaus, G. J. A., Berns, A. J. M., and Borst, P. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell, 75: 451-462, 1993.
12. Ruetz, S., and Gros, P. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell, 77: 1071-1081, 1994.
13. Ruetz, S., and Gros, P. Enhancement of mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate. J. Biol. Chem., 270: 25388-25395, 1995.
14. Smith A. J., Timmermans-Hereijgers, J. L. P. M., Roelofsen, B., Wirtz, K. W. A., van Blitterswijk, W. J., Smit, J. J. M., Schinkel, A. H., and Borst, P. The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice. FEBS Lett., 354: 263-266, 1994.
15. Bird, A. P. CpG-rich islands and the function of DMA methylation. Nature (Lond.), 321: 209-213, 1986.
16. Dynan, W. S. Promoters for housekeeping genes. Trends Genet., 2: 196-197, 1986.
17. Larsen, F., Gundersen, G., Lopez, R., and Prydz, H. CpG islands as gene markers in the human genome. Genomics, 13: 1095-1107, 1992.
18. Faisst, S., and Meyer, S. Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res., 20: 3-26, 1992.
19. Briggs, M. R., Kadonaga, J. T., Bell, S. P., and Tjian, R. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science (Washington DC), 234: 47-52, 1986.
20. Jantzen, K., Fritton, H. P., Igo-Kemenes, T., Espel, E., Janich, S., Cato, A. C. B., Mugele, K., and Beato, M. Partial overlapping of the binding sequences for steroid hormone receptors and DNase I hypersensitive sites in the rabbit uteroglobin gene region. Nucleic Acids Res., 15: 4535-4552, 1987.
21. Mitchell, P. J., Wang, C., and Tjian, R. Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell, 50: 847-861, 1987.
22. Ho, I-C., Bhat, N. K., Gottschalk, L. R., Lindsten, T., Thompson, C. B., Papas, T. S., and Leiden, J. M. Sequence-specific binding of human Ets-1 to the T cell receptor α gene enhancer. Science (Washington DC), 250: 814-818, 1990.
23. Fujisawa-Sehara, A., Yamane, M., and Fujii-Kuriyama, Y. A DMA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus. Proc. Nat. Acad. Sci. USA, 85: 5859-5863, 1988.
24. Smit, J. J. M., Mol, C. A. A. M., van Deemter, L., Wagenaar, E., Schinkel, A. H., and Borst, P. Characterization of the promoter region of the human MDR3 P-glycoprotein gene. Biochim. Biophys. Acta, 1261: 44-56, 1995.
25. Javahery, R., Khachi, A., Lo, K., Zenzie-Gregory, B., and Smale, S. T. DMA sequence requirements for transcriptional initiator activity in mammalian cells. Mol. Cell. Biol., 14: 116-127, 1994.
26. Ueda, K., Pastan, I., and Gottesman, M. M. Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. J. Biol. Chem., 262: 17432-17436, 1987.
27. Lincke, C. R., Smit, J. J. M., van der Velde Koerts, T., and Borst, P. Structure of the human MDR3 gene and physical mapping of the human MDR tocus. J. Biol. Chem., 266: 5303-5310, 1991.
28. Brown, P. C., Thorgeirsson, S. S., and Silverman, J. A. Cloning and regulation of the rat mdr2 gene. Nucleic Acids Res., 27: 3885-3891, 1993.
29. Cornwell, M. M. The human multidrug resistance gene: sequences upstream and downstream of the initiation site influence transcription. Cell Growth & Differ., 1: 607-615, 1990.
30. Buskin, J. N., and Hauschka, S. D. Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene. Mol. Cell. Biol., 9: 2627-2640, 1989.
31. Sorkin, B. C., Jones, F. S., Cunningham, B. A., and Edelman, G. M. Identification of the promoter and a transcriptional enhancer of the gene encoding L-CAM, a calcium-dependent cell adhesion molecule. Proc. Natl. Acad. Sci. USA, 90: 11356-11360, 1993.
32. Neznanov, N. S., and Oshima, R. G. cis-Regulation of the keratin 18 gene in transgenic mice. Mol. Cell. Biol., 13: 1815-1823, 1993.
33. Brooks, A. R., Nagy, B. P., Taylor, S., Scott Simonet, W., Taylor, J. M., and Levy-Wilson, B. Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic mice. Mol. Cell. Biol., 14: 2243-2255, 1994.
34. Parmacek, M. S., Ip, H. S., Jung, F., Shen, T., Martin, J. F., Vora, A. J., Olson, E. N., and Leiden, J. M. A novel myogenic regulatory circuit controls slow/cardiac troponin C gene transcription in skeletal muscle. Mol. Cell. Biol., 14: 1870-1885, 1994.
35. Hamann, L., Bayer, K-U., Jensen, K., and Harbers, K. Interaction of several related GC-box- and GT-box-binding proteins with the intronic enhancer is required for differential expression of the gb110 gene in embryonal carcinoma cells. Mol. Cell. Biol., 14: 5786-5793, 1994.
36. Greenberger, L. M., Lothstein, L., William, S. S., and Horwitz, S. B. Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc. Natl. Acad. Sci. USA, 85: 3762-3766, 1988.
37. Kingston, R. E. Primer Extension in Current Protocols in Molecular Biology. In: F. M. Aususbel (ed.), Vol. 1, pp. 4.8.1-4.8.3. New York: John Wiley & Sons, 1988.
38. Nordeen, S. K. Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechnology, 6: 454-457, 1988.
39. Feigner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., Ringold, G. M., and Danielsen, M. Lipofectin: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA, 84: 7413-7417, 1987.
40. Brasier, A. R., Tate, J. E., and Habener, J. F. Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechnology, 7: 1116-1122, 1989.
41. Subramaniam, A., Gulick, J., and Robbins, J. Analysis of the upstream regulatory region of a chicken skeletal myosin heavy chain gene. J. Biol. Chem., 255: 13986-13994, 1990.
42. Yu, L., Cohen, D., Piekarz, R. L., and Horwitz, S. B. Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene. J. Biol. Chem., 268: 7520-7526, 1993.
43. Baldwin, A. S. Methylation Interference Assay in Current Protocols in Molecular Biology, Vol. 2, pp. 12.3.1-12.3.6. : New York: John Wiley & Sons, 1988.
44. Imbert, J., Zafarullah, M., Culotta, V. C., Gedamu, L., and Hamer, D. Transcription factor MBF-1 interacts with metal regulatory elements of higher eucaryotic metallothionein genes. Mol. Cell. Biol., 9: 5315-5323, 1989.
45. Chiu, R., Imagawa, M., Imbra, R. J., Bockoven, J. R., and Karin, M. Multiple cis- and frans-acting elements mediate the transcriptional response to phorbol esters. Nature (Lond.), 329: 648-651, 1987.
46. Chodosh, L. A., Baldwin, A. S., Carthew, R. W., and Sharp, P. A. Human CCAAT-binding proteins have heterologous subunits. Cell, 53: 11-24, 1988.
47. Yu, L., Wu, Q., Yang, C. P. H., and Horwitz, S. B. Coordination of transcription factors, NF-γ and C/EBPβ, in the regulation of the mdr1b promoter. Cell Growth & Differ., 6: 1505-1512, 1995.