Genes and physiology: Molecular physiology in genetically engineered animals

Journal of Clinical Investigation

Volumn 98, Issue 11 SUPPL., 1996, Pages

  Chien, Kenneth R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR DISEASE; GENE LOCATION; GENETIC ENGINEERING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; LIPOPROTEIN METABOLISM; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SPECIES DIFFERENCE;

EID: 0029805388     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (66)

1. Chien, K.R. 1993. Molecular advances in cardiovascular biology. Science (Wash. DC). 260:916-917.
2. Lin, M.C., H.A. Rockman, and K.R. Chien. 1995. Heart and lung disease in engineered mice. Nature Med. 1:749-751.
3. Curran, M.E., I. Splawski, K.W. Timothy, G.M. Vincent, E.D. Green, and M.T. Keating. 1995. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 80:795-803.
4. Sanguinetti, M.C., C. Jiang, M.E. Curran, and M.T. Keating. 1995. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81:299-307.
5. Geisterfer-Lowrance, A.A., S. Kass, G. Tanigawa, H.P. Vosberg, W. McKenna, C.E. Seidman, and J.G. Seidman. 1990. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell. 62:999-1006.
6. Tanigawa, G., J.A. Jarcho, S. Kass, S.D. Solomon, H.P. Vosberg, J.G. Seidman, and C.E. Seidman. 1990. A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. Cell. 62:991-998.
7. Thierfelder, L., H. Watkins, C. MacRae, R. Lamas, W. McKenna, H.P. Vosberg, J.G. Seidman, and C. E. Seidman. 1994. Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell. 77:701-712.
8. Rudnicki, M.A., P.N. Schnegelsberg, R.H. Stead, T. Braun, H.H. Arnold, and R. Jaenisch. 1993. MyoD or Myf-5 is required for the formation of skeletal muscle. Cell. 75:1351-1359.
9. Jacks, T., T.S. Shih, E.M. Schmitt, R.T. Bronson, A. Bernards, and R.A. Weinberg. 1994. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat. Genet. 7:353-361.
10. Brannan, C.I., A.S. Perkins, K.S. Vogel, N. Ratner, M.L. Nordlund, S.W. Reid, A.M. Buchberg, N.A. Jenkins, L.F. Parada, and N.G. Copeland. 1994. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8:1019-1029.
11. Gruber, P.J., S.W. Kubalak, H.M. Sucov, R.M. Evans, T. Pexieder, and K.R. Chien. 1995. RXRα deficiency confers genetic susceptibility to aortic sac, conotruncal, atrioventricular cushion, and ventricular morphogenic defects. Circulation. 92:I368. (Abstr.)
12. Kastner, P., J.M. Grondona, M. Mark, A. Gansmuller, M. LeMeur, D. Decimo, J-L. Vonesch, P. Dollé, and P. Chambon. 1994. Genetic analysis of RXRα developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell. 78:987-1003.
13. Sucov, H., M.E. Dyson, C.L. Gumeringer, J. Price, K.R. Chien, and R.M. Evans. 1994. RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 8:1007-1018.
14. Jacobs, R.E., and S.E. Fraser. 1994. Magnetic resonance microscopy of embryonic cell lineages and movements. Science (Wash. DC). 263:681-684.
15. Smith, B.R., G.A. Johnson, E.V. Groman, and E. Linney. 1994. Magnetic resonance microscopy of mouse embryos. Proc. Natl. Acad. Sci. USA. 91: 3530-3533.
16. Dyson, E., H. Sucov, S.W. Kubalak, G. Schmid-Schönbein, F. Delano, R.M. Evans, J. Ross, Jr., and K.R. Chien. 1995. Atrial-like phenotype is associated with embryonic ventricular failure in RXRα-/- mice. Proc. Natl. Acad. Sci. USA. 92:7386-7390.
17. Breslow, J.L. 1993. Transgenic mouse models of lipoprotein metabolism and atherosclerosis. Proc. Natl. Acad. Sci. USA. 90:8314-8318.
18. Stoltzfus, L., and E.M. Rubin. 1993. Atherogenesis: insights from the study of transgenic and gene-targeted mice. Trends Cardiovasc. Med. 3:130-134.
19. Plump, A.S., J.D. Smith, T. Hayek, K. Aalto-Setala, A. Walsh, J.G. Verstuyft, E.M. Rubin, and J.L. Breslow. 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 71:343-353.
20. Zhang, S.H., R.L. Reddick, J.A. Piedrahita, and N. Maeda. 1992. Spontaneous hyperchloesterolemia and arteriallesions in mice lacking apolipoprotein E. Science (Wash. DC). 258:468-471.
21. Nakashima, Y, A.S. Plump, E.W. Raines, J.L. Breslow, and R. Ross. 1994. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Throm. 14:133-140.
22. Reddick, R.L., S.H. Zhang, and N. Maeda. 1994. Atherosclerosis in mice lacking apoE: evaluation of lesional development and progression. Arterioscl. Thromb. 14:141-147.
23. Palinski, W., V.A. Ord, A.S. Plump, J.L. Breslow, D. Steinberg, and J.L. Witzum. 1994. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Arterioscler. Thromb. 14:605-616.
24. Paszty, C., N. Maeda, J. Verstuyft, and E.M. Rubin. 1994. Apolipoprotein Al transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J. Clin. Invest. 94:899-903.
25. Van der Maagenberg, A.M.J.M., M.H. Hofker, P.J. Krimpenfort, I. de Bruijn, B. van Vlijmen, H. van der Boom, L.M. Havekes, and R.R. Frants. 1993. Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia. J. Biol. Chem. 268:10540-10545.
26. Fazio, S. 1993. Recent insights into the pathogenesis of type III hyperlipoproteinemia. Trends Cardiovas. Med. 3:191-196.
27. Shimano, H. N. Yamada, M. Katsuki, M. Shimada, T. Gotoda, K. Harada, T. Murase, C. Fukazawa, F. Takaku, and Y. Yazaki. 1992. Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia. Proc. Natl. Acad. Sci. USA. 89:1750-1754.
28. Tangirala, R.K., F. Casanada, E. Miller, J.L. Witzum, D. Steinberg, and W. Palinski. 1995. Effect of antioxidant N., N′-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in ApoE-deficient mice. Arterioscl. Thromb. 15: 1625-1630.
29. Hanks, M., W. Wurst, L. Anson-Cartwright, A.B. Auerback, and A.L. Joyner. 1995. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science (Wash. DC). 269:679-682.
30. Gossen, M., S. Freundlieb, G. Bender, G. Muller, W. Hillen, and H. Bujard. 1995. Transcriptional activation by tetracyclines in mammalian cells. Science (Wash. DC). 268:1766-1769.
31. Kuhn, R., F. Schwenk, M. Aguet, and K. Rajewsky. 1995. Inducible gene targeting in mice. Science (Wash. DC). 269:1427-1429.
32. Metzger, D., J. Clifford, H. Chiba, and P. Chambon. 1995. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc. Natl. Acad. Sci. USA. 92:6991-6995.
33. No, D., T-P. Yao, and R.M. Evans. 1996. Ecdysone inducible gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA. In press.
34. Chien, K.R. 1995. Cannon Award Lecture. Cardiac muscle diseases in genetically engineered mice: the evolution of molecular physiology. Am. J. Physiol. 269:H753-H766.
35. 2-adrenergic receptor. Science (Wash. DC). 264:582-586.
36. 2-adrenoceptor. Nature (Lond.). 374: 272-276.
37. Koch, W.J., H.A. Rockman, R. Samama, R.A. Hamilton, R.A. Bond, C.A. Milano, and R.J. Lefkowitz. 1995. Reciprocally altered cardiac function in transgenic mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science (Wash. DC). 268:1350-1353.
38. Chien, K.R., H. Zhu, K.U. Knowlton, W. Miller-Hance, M. van Bilsen, T.X. O'Brien, and S.M. Evans. 1993. Transcriptional regulation during cardiac growth and development. Annu. Rev. Physiol. 55:77-95.
39. Morgan, H.E., and K.M. Baker. 1991. Cardiac hypertrophy. Mechanical, neural, and endocrine dependence. Circulation. 83:13-25.
40. Wollen, K.C., T. Taga, T. Kishimoto, C.C. Glembotski, A.B. Vernallis, J.K. Heath, D. Pennica, W.I. Wood, and K.R. Chien. 1996. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy: assembly of sarcomeric units in series via gp130/leukemia inhibitory factor receptor dependent pathways. J. Biol. Chem. In press.
41. Rockman, H.A., K.U. Knowlton, J.R. Ross, Jr., and K.R. Chien. 1993. In vivo murine cardiac hypertrophy: a novel model to identify genetic signaling mechanisms that activate an adaptive physiologic response. Circulation. 87:14-21.
42. Rockman, H.A., S. Ono, R.S. Ross, L.R. Jones, M. Karimi, V. Bhargava, J. Ross, Jr., and K.R. Chien. 1994. Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl. Acad. Sci. USA. 91:2694-2698.
43. Rockman, H.A., R.S. Ross, A.N. Harris, K.U. Knowlton, M.E. Steinhelper, L. Field, J. Ross, and K.R. Chien. 1996. Segregation of atrial specific and inducible expression of an ANF transgene in an in vivo murine model of cardiac hypertrophy. Proc. Natl. Acad. Sci. USA. 88:8277-8281.
44. S.W. Kubalak, P.A. Doevendans, H.A. Rockman, J.J. Hunter, N. Tanaka, J. Ross, Jr., and K.R. Chien. 1996. Molecular analysis of cardiac muscle diseases via mouse genetics. In Methods in Molecular Genetics, K.W. Adolph, editor. Academic Press, Orlando, Florida. In press.
45. Hunter, J.J., N. Tanaka, H.A. Rockman, J. Ross, Jr., and K.R. Chien. 1995. Ventricular expression of a MCL-2v-Ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J. Biol. Chem. 270:32173-23178.
46. Thorburn, A., J. Thorburn, S-Y. Chen, S. Powers, H.E. Shubeita, J.R. Feramisco, and K.R. Chien. 1993. HRas dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J. Biol. Chem. 268:2244-2249.
47. Zhou, M.D., H.M. Sucov, R.M. Evans, and K.R. Chien. 1995. Retinoid dependent pathways suppress myocardial cell hypertrophy. Proc. Natl. Acad. Sci. USA. 92:7391-7395.
48. Pennica, D., K.L. King, K.J. Shaw, E. Luis, J. Rullamas, S-M. Luoh, W.C. Darbonne, D.S. Knutzon, R. Yen, K.R. Chien, J.B. Baker, and W.I. Wood. 1995. Expression cloning of cardiotrophin-1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. USA. 92:1142-1146.
49. Sheng, Z., D. Pennica, W.I. Wood, and K.R. Chien. 1996. Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development. In press.
50. 1-adrenergic stimulation. J. Biol. Chem. 269:13490-13496.
51. John, S.W.M., J.H. Krege, P.M. Oliver, J.R. Hagaman, J.B. Hodgin, S.C. Pang, T.G. Flynn, and O. Smithies. 1995. Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science (Wash. DC). 267:679-681.
52. Kim, H.S., J.H. Krege, K.D. Kluckman, J.R. Hagaman, J.B. Hodgin, C.F. Best, J.C. Jennette, T.M. Coffman, N. Maeda, and O. Smithies. 1995. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. USA. 92:2735-2739.
53. Krege, J.H., S.W.M. John, L.L. Laugenback, J.B. Hodgin, J.R. Hagaman, E.S. Backman, J.C. Jennette, D.A. O'Brien, and O. Smithies. 1995. Male-female differences in fertility and blood pressures in ACE deficient mice. Nature (Lond). 315:146-148.
54. Huang, P.L., Z. Huang, H. Mashimo, K.D. Bloch, M.A. Moskowitz, J.A. Bevan, and M.C. Fishman. 1995. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (Lond.). 377:239-242.
55. Tanaka, N., N. Dalton, H.A. Rockman, K.L. Peterson, J.J. Hunter, K.R. Chien, and J. Ross, Jr. 1996. Transthoracic echocardiography in the normal and abnormal mouse heart. Circulation. In press.
56. Gardin, J.M., F.M. Siri, R.N. Kitsis, J.G. Edwards, and L.A. Leinwand. 1995. Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ. Res. 76:907-914.
57. Libby, P. 1995. Lesion versus lumen. Nature Med. 1:17-18.
58. Ishibashi, S., M.S. Brown, J.L. Goldstein, R.D. Gerard, R.E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92:883-893.
59. Lawn, R.M., D.P. Wade, R.E. Hammer, G. Chiesa, J.G. Verstuyft, and E.M. Rubin. 1992. Atherogenesis in transgenic mice expressing human apolipoprotein(a). Nature (Lond.). 360:670-672.
60. Chien, K.R., and A.A. Grace. 1996. Principles of cardiovascular molecular and cellular biology. In Heart Disease, Fifth Edition, E. Braunwald, editor. W.B. Saunders Company, Orlando, Florida. In press.
61. Geisterfer-Lowrance, A., M. Christe, D. Conner, D. Ladd, S. Ingwalls, F. Schoen, C. Seidman, and J.G. Seidman. 1995. A targeted missense mutation in alpha-myosin heavy chain gene leads to alterations in physiologic phenotype in the mouse. Circulation. 92:I-233.
62. Hirota, H., K. Yoshida, T. Kishimoto, and T. Taga. 1995. Continuous activation of gp130, a signal transducing receptor component for interleukin 6-related cytokines causes myocardial hypertrophy in mice. Proc. Natl. Acad. Sci. USA. 92:4862-4866.
63. Milano, C.A., P.C. Dolber, H.A. Rockman, R.A. Bond, M.E. Venable, L.F. Allen, and R.J. Lefkowitz. 1994. Myocardial expression of a constitutively active alpha 1β-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc. Natl. Acad Sci. USA. 91:10109-10113.
64. Chisaka, O., and M.R. Capecchi. 1991. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature (Lond.). 350:473-479.
65. Kurihara, Y., H. Kurihara, H. Oda, K. Maemura, R. Nagai, T. Ishikawa, and Y. Yazaki. 1995. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J. Clin. Invest. 96:293-300.
66. Reaume, A.G., P.A. de Sousa, S. Kulkarni, B.L. Langille, D. Zhu, T.C. Davies, S.C. Juneja, G.M. Kidder, and J. Rossant. 1995. Cardiac malformations in neonatal mice lacking connexin43. Science (Wash. DC). 267:1831-1834.