Expression of cyclin D1 and c-Ki-ras gene product in human epithelial ovarian tumors

Human Pathology

Volumn 27, Issue 12, 1996, Pages 1324-1328

  Hung, Wen Chun ^a   Chai, Chee Yin ^a   Huang, Jau Shyang ^a   Chuang, Lea Yea ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

c Ki ras; cyclin D1; ovarian tumors

Indexed keywords

CYCLIN DEPENDENT KINASE; GENE PRODUCT;

ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CANCER STAGING; CELL CULTURE; CHROMOSOME 11Q; CLINICAL ARTICLE; DATA ANALYSIS; ENZYME ACTIVITY; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; OVARY TUMOR; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS;

EID: 0029805029     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(96)90345-7     Document Type: Article

References (29)

1. Sesano H, Garrett CT, Wilkinson DS, et al: Protooncogene amplification and tumor ploidy in human ovarian neoplasms. HUM PATHOL 21:382-391, 1990
2. Berchuck A, Kamel A, Whitaker R, et al: Overexpression of Her-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 50:4087-4091, 1990
3. K gene in a human ovarian carcinoma. Science 223:698-701, 1984
4. Li SE, Schwartz PE, Lee WH, et al: Allele loss at the retinoblastoma locus in human ovarian cancer. J Natl Cancer Inst 83:637-640, 1991
5. Lee JH, Kavanagh JJ, Wildrick DM, et al: Frequent loss of heterozygosity on chromosome 6q, 11 and 17 in human ovarian carcinomas. Cancer Res 50:2724-2728, 1990
6. Chien CH, Chang KT, Chow SN: Amplification and expression of c-Ki-ras oncogene in human ovarian cancer. Proc Natl Sci Council ROC 14:27-32, 1990
7. Zhou DJ, Gonzalez-Cadavid N, Ahuja H, et al: A unique pattern of protooncogene abnormalities in ovarian adenocarcinomas. Cancer 62:1573-1576, 1988
8. Mok SCH, Bell DA, Knapp RC, et al: Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy. Cancer Res 53:1489-1492, 1993
9. Scambia G, Gatozzi L, Panici PB, et al: Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues: Correlation with histopathological features and receptors for estrogen, progesterone, and epidermal growth factor. Am J Obstet Gynecol 168:71-78, 1993
10. Boltz EM, Keford RF, Leary JA, et al: Amplification of c-Ki-ras oncogene in human ovarian tumors. Int J Cancer 43:428-430, 1989
11. van't Veer LJ, Hermens R, van den Berg-Bakker LA, et al: Ras oncogene activation in human ovarian cancinoma. Oncogene 2:157-165, 1988
12. Teneriello MG, Ebina M, Liinnoila RI, et al: p53 and Ki-ras Gene mutations in epithelial ovarian neoplasms. Cancer Res 53:3103-3108, 1993
13. Boeente MP, Hurteau J, Rodriguez GC, et al: The bioloogy of ovarian cancer. Curr Opin Oncol 5:900-907, 1993
14. Gallion HH, Pierettii M, DePriest PD, et al: The molecular basis of ovarian cancer. Cancer 76:1992-1997, 1995
15. Sherr CJ: Mammalian G1 cyclins. Cell 73:1059-1065, 1993
16. Hunter T, Pines J: Cyclins and cancer. Cell 66:1071-1074, 1991
17. Jiang W, Kahn SM, Tomita N, et al: Amplification and expreson of the human Cyclin D gene in esophageal cancer. Cancer Res 52:2980-2983, 1992
18. Buckley MF, Kimberley JE, Sweeney JE, et al: Expression and amplification of cyclin genes in human breast cancer. Oncogene 8:2127-2133, 1993
19. Schuuring E, Verhoeven E, Mooi WJ, et al: Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinoma. Oncogene 7:355-361, 1992
20. Motokura T, Bloom T, Kim HG, et al: A novel cyclin encoded by a bcl-linked candidate oncogene. Nature 350:512-515, 1991
21. Foulkes WD, Campbell IG, Stamp GWH, et al: Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer. Br J Cancer 83:268-273, 1993
22. Filmus J, Robles AI, Shi W, et al: Induction of cyclin D1 overexpression by activated ras. Oncogene 9:3627-3633, 1994
23. Lovec H, Sewing A, Lucibello FC, et al: Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: Link between cell cycle control and malignant transformation. Oncogene 9:323-326, 1994
24. Broder AC: Practical points on the microscopic grading of carcinoma. NY State J Med 32:667-671, 1932
25. Jiang W, Kahn SM, Zhou P, et al: Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8:3447-3457, 1993
26. Wang TC, Cardiff RD, Zukerberg L, et al: Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 369:669-671, 1994
27. Zhou P, Jiang W, Zhang YJ, et al: Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells. Oncogene 11:571-580, 1995
28. Bartkova J, Lukas J, Strauss M, et al: Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein. J Pathol 172:237-245, 1994
29. Bartkova J, Lukas J, Strauss M, et al: Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 10:775-778, 1995