Effects of methyl substitutions on benz[a]anthracene derivatives-induced immunosuppression

Journal of Toxicology and Environmental Health - Part A

Volumn 49, Issue 4, 1996, Pages 371-387

  Saas, P ^a,b   Bohuon, C ^a,b   Pallardy, M ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZ[A]ANTHRACENE DERIVATIVE; CONCANAVALIN A; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; OKT 3; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; FEMALE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; BENZ(A)ANTHRACENES; CARCINOGENS; CELL CYCLE; CELL DIVISION; CONCANAVALIN A; FEMALE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; INTERLEUKIN-2; INTERLEUKIN-6; LETHAL DOSE 50; METHYLATION; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

ANIMALIA; MURINAE;

EID: 0029804939     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Altman, A., Coggeshall, M., and Mustelin, T. 1990. Molecular events mediating T cell activation. Adv. Immunol. 48:227-360.
2. Archuleta, M. M., Schieven, G. L., Ledbetter, J. A., Deanin, G. G., and Burchiel, S. W. 1993. 7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-γ1, formation of inositol 1,4,5-triphosphate, and mobilization of intracellular calcium. Proc. Natl. Acad. Sci. USA 90:6105-6109.
3. Burchiel, S. W., Davis, D. A. P., Gomez, M. P., Montano, R. M., Barton, S. L., and Seamer, L. C. 1990. Inhibition of lymphocyte activation in splenic and gut-associated lymphoid tissues following oral exposure of mice to 7,12-dimethylbenz(a)anthracene. Toxicol. Appl. Pharmacol. 105:434-442.
4. Dean, J. H., Luster, M. I., Boorman, G. A., Lauer, L. D., Luebke, R. W., and Lawson, L. 1983. Selective immunosuppression resulting from exposure to the carcinogenic congener of benzopyrene in B6C3F1 mice. Clin. Exp. Immunol. 52:199-206.
5. Dean, J. H., Ward, E. C., Murray, M. J., Lauer, L. D., House, R. V., Stillman, W., Hamilton, T. A., and Adams, D. O. 1986. Immunosuppression following 7,12-dimethylbenz(a)anthracene exposure in B6C3F1 mice: Altered cell mediated immunity and tumor resistance. Int. J. Immunopharmacol. 8:189-198.
6. De Saint Basile, G., Le Deist, F., Caniglia, M., Le Branchu, Y., Griscelli, C., and Fischer, A. 1992. Genetic study of a new X-linked recessive immunodeficiency syndrome. J. Clin. Invest. 89:861-866.
7. Dinarello, C. A. 1994. The biologicals properties of interleukin-1: Eur. Cytokine Network 5:517-531.
8. Di Padova, F. E. 1989. Pharmacology of cyclosporine (Sandimmune). V - Pharmacological effects on immune function: In vitro studies. Pharmacol. Rev. 41:373-405.
9. Hecht, S. S., Assieh, A. M., and Shantu, A. 1986. Effects of methyl on the tumogenicity and metabolic activation of polycyclic aromatic hydrocarbons. In Polycyclic aromatic hydrocarbons carcinogenesis, Structure activity relationships, eds. S. K. Yang and B. D. Silverman, pp. 95-127. Boca Raton, FL: CRC Press.
10. House, R. V., and Dean, J. H. 1987. Studies on structural requirements for suppression of cytotoxic T lymphocyte induction by polycyclic compounds. In Vitro Toxicol. 1:149-162.
11. House, R. V., Lauer, L. D., Murray, M. J., and Dean, J. H. 1987. Suppression of T-helper cell function in mice following exposure to carcinogen 7,12-dimethylbenz(a)anthracene and its restoration by interleukin-2. Int. J. Immunopharmacol. 9:89-97.
12. House, R. V., Pallardy, M. J., and Dean, J. H. 1989a. Suppression of murine cytotoxic T-lymphocyte induction following exposure to 7,12-dimethylbenz(a)anthracene: Dysfunction of antigen recognition. Int. J. Immunopharmacol. 11:207-215.
13. House, R. V., Pallardy, M. J., Burleson, G. R., and Dean, J. H. 1989b. 7,12-Dimethylbenz(a)-anthracene-induced modulation of cytokines involved in cytotoxic T lymphocyte induction. In Vitro Toxicol. 2:267-278.
14. Houssiau, F., and Van Snick, J. 1992. IL-6 and the T-cell response. Res. Immunol. 143:740-743.
15. Liu, J. 1993. FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. Immunol. Today 14(6):290-295.
16. Miyazaki, T., Liu, Z. J., Kawahara, A., Minami, Y., Yamada, K., Tsujimuto, Y., Barsoumian, E. L., Perimutter, R. M., and Taniguchi, T. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81:223-231.
17. Noguchi, M., Yi, H., Rosenblatt, H. M., Filipovitch, A. H., Adelstein, S., Modi, W. S., McBride, O. W., and Leonard, W. J. 1993. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in human. Cell 73:147-157.
18. Page, T. H., and Dallman, M. J. 1991. Molecular cloning of cDNAs for the rat interleukin 2 receptor α and β chain genes: Differentially regulated gene activity in response to mitogenic stimulation. Eur. J. Immunol. 21:2133-2138.
19. Pallardy, M. J., House, R. V., and Dean, J. H. 1989. Molecular mechanism of 7,12-dimethylbenz(a)anthracene-induced immunosuppression: Evidence for action via the interleukin-2 pathway. Mol. Pharmacol. 36:128-133.
20. Paul, W. E., and Seder, R. A. 1994. Lymphocyte responses and cytokines. Cell 76:241-251.
21. Penn, I. 1977. Development of cancer as a complication of clinical transplantation. Transplant. Proc. 9(1):1121-1127.
22. Robb, R. J., Mayer, P. C., and Garlick, R. 1985. Retention of biological activity following radioiodination of human interleukin-2: Comparison with biosynthetically labeled growth factor to receptor binding assays. J. Immunol. Methods 81:15-30.
23. Saboori, A. M., and Newcombe, D. S. 1992. Environmental chemicals with immunotoxic properties. In Clinical immunotoxicology, eds. D. S. Newcombe, N. R. Rose, and J. C. Bloom, pp. 379-383. New York: Raven Press.
24. Sheil, A. G. R., Flavel, S., and Disry, A. P. S. 1987. Cancer incidence in renal transplant patients treated with azathioprine or cyclosporine. Transplant. Proc. 19:2214-2216.
25. Takeshita, T., Asao, H., Ohtani, K., Isshi, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M., and Sugamura, K. 1992. Cloning of the γ chain of the human IL-2 receptor. Science 257:379-382.
26. Taniguchi, T., and Minami, Y. 1993. The IL-2/IL-2 receptor system: A current overview. Cell 73:5-8.
27. Thurmond, L. M., House, R. V., Lauer, L. D., and Dean, J. H. 1988. Suppression of splenic lymphocyte function by 7,12-dimethylbenz(a)anthracene in vitro. Toxicol. Appl. Pharmacol. 93:363-377.
28. Thurmond, L. M., House, R. V., and Dean, J. H. 1991. Disturbance of calcium signalling and phosphoinositide metabolism in murine lymphocytes by 7,12-dimethylbenz[a]anthracene. In Vitro. Toxicol. 4:217-230.
29. Vink, A., Uyttenhove, C., Wauters, P., and Van Snick, J. 1990. Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor. Eur. J. Immunol. 20:1-6.
30. Ward, E. C., Murray, M. J., Lauer, L. D., House, R. V., Irons, R. D., and Dean, J. H. 1984. Immunosuppression following 7,12-dimethylbenz(a)anthracene exposure in B6C3F1 mice: Effects on humoral immunity and host resistance. Toxicol. Appl. Pharmacol. 75:299-308.
31. Ward, E. C., Murray, M. J., and Dean, J. H. 1985. Immunotoxicity of nonhalogenated polycyclic aromatic hydrocarbons. In Immunotoxicology and immunopharmacology, ed. J. Dean, pp. 291-303. New York: Raven Press.
32. White, K. L., Jr. 1986. An overview of immunotoxicology and carcinogenic polycyclic aromatic hydrocarbons. J. Environ. Sci. Health 2:163-202.