Vascular hyporesponsiveness in aortic rings from cirrhotic rats: Role of nitric oxide and endothelium

Clinical Science

Volumn 91, Issue 6, 1996, Pages 733-738

  Ortíz, M Clara ^a   Fortepiani, Lourdes A ^a   Martínez, Concha ^a   Atucha, Noemí M ^a   García Estañ, Joaquín ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

Acetylcholine; Aorta; Endothelium; Liver cirrhosis; Nitric oxide; Phenylephrine

Indexed keywords

ACETYLCHOLINE; AMINOGUANIDINE; ISOENZYME; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BILE DUCT; CONTROLLED STUDY; EXPERIMENTAL LIVER CIRRHOSIS; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

EID: 0029804856     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0910733     Document Type: Article

References (26)

1. Vallance P, Moncada S. Hyperdynamic circulation in cirrhosis: a role for nuitric oxide? Lancet 1992; 337: 776-8.
2. Green N, Better OS. Altered systemic hemodynamics in obstructive jaundice. J Am Soc Nephrol 1995; 5: 1855-71.
3. Romero JC, García-Estañ J, Atucha NM. Nitric oxide and renal function: the control of blood pressure under normal conditions and during cirrhosis. In: Epstein M, ed. The kidney in liver disease. Philadelphia: Hanley and Belphus, 1996: 373-85.
4. Pizcueta MP, Casamitjana R, Bosch J, Rodés J. Decreased systemic vascular sensitivity to norepinephrine in portal hypertensive rats: role of hyperglucagonism. Am J Physiol 1990; 258: G191-5.
5. Bomzon A, Jacob G, Lee SS, Meddings J. In vitro vascular responsiveness to norepinephrine in experimental portal hypertension. Clin Invest Med 1991; 14: 63-71.
6. Sieber CC, Groszmann RJ. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology 1992; 103: 235-9.
7. Lee FY, Albillos A, Colombato LA, Groszmann RJ. The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats. Hepatology 1992; 16: 1043-8.
8. Castro A, Jiménez W, Clària J, et al. Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology 1993; 18: 367-72.
9. Karatapanis S, McCormick PA, Kakad S, et al. Alteration in vascular reactivity in isolated aortic rings from portal vein-constricted rats. Hepatology 1994; 20: 11516-21.
10. Liao JF, Yu PC, Lin HC, Lee F, Kuo JS, Yang MC. Study on the vascular reactivity and alfa-1-adrenoceptors of portal hypertensive rats. Br J Pharmacol 1994; 111: 439-44.
11. Clària J, Jiménez W, Ros J, et al. Increased nitric oxide-dependent vasorelaxation in aortic rings of cirrhotic rats with ascites. Hepatology 1994; 20: 1615-21.
12. García-Estañ J, Atucha NM, Sabio JM, Vargas F, Quesada T, Romero JC. Increased endothelium-dependent renal vasodilation in cirrhotic rats. Am J Physiol 1994; 267: R549-53.
13. Lee SS, Pak J-M, Medlicott SM, Bomzon A. Vasodilatory responses of isolated arteries of cirrhotic rats. Clin Sci 1995; 89: 227-32.
14. Obbergh LV, Leonard V, Chen H, Xu D, Biaise G. The endothelial and non-endothelial mechanism responsible for attenuated vasoconstriction in cirrhotic rats. Exp Physiol 1995; 80: 609-17.
15. Atucha NM, García-Estañ J, Ramírez A, Pérez MC, Quesada T, Romero JC. Renal effects of nitric oxide synthesis inhibition in cirrhotic rats. Am J Physiol 1994; 267: R1454-60.
16. Sogni P, Moreau R, Ohsuga M, et al. Evidence for normal nitric oxide-mediated vasodilator tone in conscious rats with cirrhosis. Hepatology 1992; 16: 980-3.
17. Ubeda M, Matzilevich M, Atucha NM, et al. Renin and angiotensinogen mRNA expression in the kidneys of rats subjected to long-term bile duct ligation. Hepatology 1994; 19: 1431-6.
18. Morris SM, Billiar TR. New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol 1994; 266: E829-39.
19. Forstermann U, Gloss EI, Pollock JS, et al. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning and functions. Hypertension 1994; 23: 1121-31.
20. Griffiths MDJ, Messent M, McAllister RJ, Evans TW. Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 1993; 110: 963-8.
21. Hasan K, Heesen BJ, Corbett JA, et al. Inhibition of nitric oxide formation by guanidines. Eur J Pharmacol 1993; 249: 101-6.
22. Misko TP, Moore WM, Kasten TP, et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 1993; 233: 119-25.
23. Joly GA, Ayres M, Chelly F, Kilbourn RG. Effects of NG-methyl-L-arginine, NG-nitro-L-arginine and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 1994; 199: 147-54.
24. Carrier GO, White RE. Enhancement of alpha-1 and alpha-2 adrenergic agonist-induced vasoconstriction by removal of endothelium in rat aorta. J Pharmacol Exp Ther 1985; 232: 682-7.
25. Demirel E, Hindioglu F, Ercan ZS, Turker RK. Endothelium modulates the effects of alpha-adrenoceptor agonists in vascular smooth muscle. Gen Pharmacol 1989; 20: 89-93.
26. Busse R, Mulsch A, Fleming I, Hecker M. Mechanisms of nitric oxide release from the vascular endothelium. Circulation 1993; 87 (Suppl. V): V18-25.