The G222D mutation in elongation factor Tu inhibits the codon-induced conformational changes leading to GTPase activation on the ribosome

EMBO Journal

Volumn 15, Issue 23, 1996, Pages 6766-6774

  Vorstenbosch, Erik ^a   Pape, Tillmann ^b   Rodnina, Marina V ^b   Kraal, Barend ^a   Wintermeyer, Wolfgang ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Codon recognition; Fluourescence stopped flow; Mechanism of A site binding; Pre steady state kinetics; Protein synthesis

Indexed keywords

AMINOACYL TRANSFER RNA; ELONGATION FACTOR TU; GUANINE NUCLEOTIDE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MAGNESIUM ION; PHENYLALANINE TRANSFER RNA; TRANSFER RNA;

AMINO ACID SEQUENCE; ANTICODON; ARTICLE; CODON; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG HYDROLYSIS; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN RNA BINDING; PROTEIN SYNTHESIS; RIBOSOME;

ESCHERICHIA COLI;

EID: 0029804685     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01066.x     Document Type: Article

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