Unilateral cooling in the region of locus coeruleus blocks the fall in respiratory output during hypoxia in anaesthetized neonatal sheep

Experimental Physiology

Volumn 81, Issue 6, 1996, Pages 983-994

  Moore, Peter J ^a   Ackland, Gareth L ^a,b   Hanson, Mark A ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PH; BREATHING; CONTROLLED STUDY; COOLING; HYPOXIA; LAMB; LOCUS CERULEUS; NERVE CONDUCTION; NEWBORN; NONHUMAN; PHRENIC NERVE;

EID: 0029804320     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.1996.sp003998     Document Type: Article

References (24)

1. BENITA, M. & CONDÉ, H. (1972). Effects of local cooling upon conduction and synaptic transmission. Brain Research 36, 133-151.
2. BLANCO, C. E., DAWES, G. S., HANSON, M. A. & MCCOOKE, H. B. (1984a). The response to hypoxia of arterial chemoreceptors in fetal sheep and newborn lambs. Journal of Physiology 351, 25-37.
3. BLANCO, C. E., HANSOM, M. A., JOHNSON, P. & RIGATTO, H. (1984b). Breathing pattern of kittens during hypoxia. Journal of Applied Physiology 56, 12-17.
4. BUREAU, M. A., ZINMAN, R., FOULON, P. & BEGIN, R. (1984). Diphasic ventilatory response to hypoxia in newborn lambs. Journal of Applied Physiology 56, 84-90.
5. CHERNIACK, N. S., EULER, C., HOMMA, I. & KAO, F. F. (1979). Graded changes in central chemoreceptor input by local temperature changes on the ventral surface of medulla. Journal of Physiology 287, 191-211.
6. DARNALL, R. A. (1985). Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Pediatric Research 19, 706-710.
7. OWES, G. S., FOX, H. E., LEDUC, B. M., LIGGINS, G. C. & RICHARDS, R. C. (1972). Respiratory movements and rapid eye movement sleep in the fetal lamb. Journal of Physiology 220, 119-143.
8. DAWES, G. S., GARDNER, W. N., JOHNSTON, B. M. & WALKER, D. W. (1983). Breathing in fetal lambs: the effect of brain stem stection. Journal of Physiology 335, 535-553.
9. DUNWIDDIE, T. V. (1985). The physiological role of adenosine in the central nervous system. International Reviews in Neurobiology 27, 63-139.
10. ELDRIDGE, F. L. (1971). Relationship between phrenic nerve activity and ventilation. Journal of Physiology 221, 535-543.
11. GIUSSANI, D. A., SPENCER, J. A. D., MOORE, P. J., BENNET, L. & HANSON, M. A. (1993). Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. Journal of Physiology 461, 431-449.
12. GLUCKMAN, P. D. & JOHNSTON, B. M. (1987). Lesions in the upper lateral pons abolish the hypoxic depression of breathing in unanaesthetized fetal lambs in utero. Journal of Physiology 382, 373-383.
13. JOHNSTON, B. M. & GLUCKMAN, P. D. (1989). Lateral pontine lesions affect central chemosensitivity in unanesthetized fetal lambs. Journal of Applied Physiology 67, 1113-1118.
14. KOOS, B. J., CHAO, A. & DOANY, W. (1992). Adenosine stimulates breathing in fetal sheep with brain stem section. Journal of Applied Physiology 72, 94-99.
15. LAGERCRANTZ, H., YAMAMOTO, Y., FREDHOLM, B. B., PRABHAKAR, N. R. & VON EULER, C. (1984). Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors? Pediatric Research 18, 387-390.
16. MARTIN-BODY, R. L. (1988). Brain transections demonstrate the central origin of hypoxic ventilatory depression in carotidy body-denervated rats. Journal of Physiology 407, 41-52.
17. MARTIN-BODY, R. L. & JOHNSTON, B. M. (1987). Central origin of the hypoxic depression of breathing in the newborn. Respiration Physiology 71, 25-32.
18. MILLHORN, D. E. & KILEY, J. P. (1984). Effect of graded cooling of intermediate areas on respiratory response to vagal input. Respiration Physiology 58, 51-64.
19. MOORE, P. J., BOHM, M. C. & HANSON, M. A. (1993). Reversible cooling in the pons abolishes the fall in respiratory activity due to adenosine in anaesthetized neonatal lambs. Journal of Physiology 473, 60 P.
20. MOORE, P. J., PARKES, M. J., NOBLE, R. & HANSON, M. A. (1991). Reversible blockade of the secondary fall of ventilation during hypoxia in anaesthetized newborn sheep by focal cooling in the brain stem. Journal of Physiology 438, 242 P.
21. NOBLE, R. (1991). Brain stem mechanisms mediating the neonatal ventilatory response to hypoxia. In The Fetal and Neonatal Brainstem. Developmental and Clinical Issues, ed. HANSOM, M. A., pp. 48-58. Cambridge University Press, Cambridge, UK.
22. SCHWEILER, G. H. (1968). Respiratory regulation during postnatal development in cat and rabbit and some of its morphological substrate. Acta Physiologica Scandinavica Supplementum 304, 1-123.
23. VIZEK, M., PICKETT, C. K. & WEIL, J. V. (1987). Biphasic ventilatory response of adult cats to sustained hypoxia has central origin. Journal of Applied Physiology 63, 1658-1664.
24. WINN, H. R., RUBIO, R. & BERNE, R. M. (1981). Brain adenosine concentrations during hypoxia in rats. American Journal of Physiology 241, H235-242.