Retention and processing of the monoclonal anti-prostate E4 antibody after binding to prostatic adenocarcinoma DU 145 cells

Cancer Immunology Immunotherapy

Volumn 43, Issue 1, 1996, Pages 39-43

  Essand, Magnus ^a   Lögdahl, Pia ^a   Nilsson, Sten ^a   Wartenberg, Maria ^b   Acker, Helmut ^b   Carlsson, Jörgen ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Monoclonal anti prostate antibody; Prostatic adenocarcinoma

Indexed keywords

CANCER ANTIBODY; IODINE 125; MONOCLONAL ANTIBODY;

ARTICLE; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA;

ADENOCARCINOMA; ANTIBODIES, MONOCLONAL; ENDOCYTOSIS; HUMANS; MALE; MICROSCOPY, CONFOCAL; PROSTATE; PROSTATIC NEOPLASMS;

EID: 0029804157     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050301     Document Type: Article

References (21)

1. Andersson A, Holmberg A, Carlsson J, Carlsson J, Pontén J, Westermark B (1991) Binding of epidermal growth factor-dextran conjugates to cultered glioma cells. Int J Cancer 47:439
2. 131I-EGF on cultered human glioma cells. J Neuro-Oncol 9:201
3. 131I-labelled E4 antibodies on cells at different depth in DU 145 speroids. Int J Cancer 63:387
4. Essand M, Nilsson S, Carlsson J (1995b) Uptake modification of a prostate-reactive monoclonal antibody in prostatic carcinoma speroids. Antibody Immunoconjugates Radiopharm 8:179
5. 125I-labelled internalized and non-internalized monoclonal antibodies in nude mice with human colon carcinoma xenografts. Nucl Med Biol 20:133
6. Geissler F, Anderson SK, Venkatesan P, Press O (1992) Intracellular catabolism of radiolabelled anti-μ antibodies by malignant B cells. Cancer Res 52:2907
7. 125I-epidermal growth factor in BALB 3T3 cells. J Biol Chem 255: 1239
8. 99mTc. Antibody Immunoconjugates Radiopharm 7:149
9. 131I)anti-B1 (anti-CD20) antibody. N Engl J Med 329:459
10. Kyriakos, RJ, Shih LB, Ong GL, Patel K, Goldenberg DM, Mattes MJ (1992) The fate of antibodies bound to the surface of tumor cells in vitro. Cancer Res 52:835
11. Matzku S, Moldenhauer G, Kalthoff H, Canevari S, Colnaghi M, Schuhmacher J, Bihl H (1990) Antibody transport and internalization into tumours. Br J Cancer [Suppl] 62:1
12. Nilsson S, Essand M, Lögdahl P, Larson A, Nordgren H, Juhlin C (1996) E4, a new monoclonal antibody identifying a human prostatic cell surface antigen. Cancer Biother Radiopharm (in press)
13. Olsson P, Lindström A, Carlsson J (1994) Internalization and excretion of epidermal growth factor-dextran-associated radioactivity in cultured human squamous-carcinoma cells. Int J Cancer 56:529
14. Press OW, Eary JF, Appelbaum FR, Martin PJ, Badger CC, Nelp WB, Glenn S, Butchko G, Fisher D, Porter B, Matthews DC, Fisher LD, Bernstein ID (1993) Radiolabelled-antibody therapy of B-cell lymphoma with autologous hone marrow support. N Engl J Med 329:1219
15. Schuster JM, Garg PK, Bigner DD, Zalutsky MR (1991) Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate, Cancer Res 51:4164
16. Shih LB, Thorp SR, Griffiths GL, Diril H, Ong GL, Hansen HJ, Goldenberg DM, Mattes MJ (1994) The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: A comparison of nine radiolabels. J Nucl Med 35:899
17. Stone KR, Mickey DD, Wunderli H, Mickey GH, Paulson DF (1978) Isolation of a human prostate carcinoma cell line (Du 145). Int J Cancer 21:274
18. Zalutsky MR, Narula AS (1987) A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. Appl Radiat Isot 38:1051
19. 2 fragments with the α-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. Proc Natl Acad Sci USA 86:7149
20. Zalutsky MR, Noska MA, Colapinto EV, Garg PK, Bigner DD (1989b) Enhanced tumour localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate. Cancer Res 49:5543
21. Zalutsky MR, Garg PK, Narula AS (1990) Labeling monoclonal antibodies with halogen nuclides. Acta Radiol [Suppl] 374:141