Regulation of the human retinoic acid receptor α gene in the estrogen receptor negative human breast carcinoma cell lines SKBR-3 and MDA-MB-435

Cancer Research

Volumn 56, Issue 22, 1996, Pages 5246-5252

  Rishi, Arun K ^a,e   Gerald, Tonya M ^b   Shao, Zhi Ming ^a   Li, Xiao Su ^a   Baumann, Richard G ^a   Dawson, Marcia I ^d   Fontana, Joseph A ^a,c  

^a Cancer Center   (United States)

^b Department of Biochemistry ^*  (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d SRI INTERNATIONAL   (United States)

^e UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; RETINOIC ACID RECEPTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETIC REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; RECEPTOR GENE; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; RECEPTORS, ESTROGEN; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0029804043     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Giguere, V Retinoic acid receptors and cellular retinoid binding proteins complex interplay in retinoid signaling Endocr Rev., 15: 61-79, 1994.
2. Gudas, L. J. Retinoids, retinoid-response genes, cell differentiation and cancer Cell Growth & Differ., 3: 655-662, 1992.
3. Moon, R. C., McCormick, D L., and Mehta, R G Inhibition of carcinogenesis by retinoids. Cancer Res., 43 (Suppl.) 2469s-2475s, 1983.
4. Bollag, W. Retinoids and cancer. Cancer Chemother Pharmacol., 3: 207-215, 1979.
5. Sheikh, M. S., Shao, Z-M., Li, X-S., Dawson, M., Jetten, A M., Wu, S., Conley, B. A., Garcia, M., Rochefort, H., and Fontana, J A Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-α acquire sensitivity to growth inhibition by retinoids J Biol. Chem., 269: 21440-21447, 1994.
6. Roman, S D., Ormandy, C. J., Manning, D. L., Blamey, R W., Nicholson, R. I., Sutherland, R. L., and Clarke, C. L Estradiol induction of retinoic acid receptors in human breast cancer cells. Cancer Res., 53: 5940-5945, 1993.
7. Fontana, J. A. Interaction of retinoids and tamoxifen in the inhibition of human mammary carcinoma cell proliferation. Exp. Cell Biol., 55: 136-144, 1987.
8. van der Burg, B., van der Leede, B. M., Kwakkenbos-Isbrucker, L., Salverda, S., de Laat, S W., and van der Saag, P T Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function. Mol. Cell. Endocrinol., 91: 149-157, 1993.
9. Roman, S D., Clarke, C L., Hall, R. E., Alexander, I. E., and Sutherland, R. L. Expression and regulation of retinoic acid receptors in human breast cancer cells. Cancer Res., 52: 2236-2242, 1992.
10. Sheikh, M S., Shao, Z-M., Chen, J-C., Hussein, A., Jetten, A. M., and Fontana, J. A. Estrogen receptor-negative breast cancer cells transfected with estrogen receptor exhibit increased RARα gene expression and sensitivity to growth inhibition by retinoic acid. J Cell Biochem., 53: 394-404, 1993.
11. Rishi, A. K., Shao, Z-M., Baumann, R. G., Li, X-S., Sheikh, M. S., Kimura, S., Bashirelahi, N., and Fontana, J. A. Estradiol regulation of the human retinoic acid receptor α gene in human breast carcinoma cells is mediated via an imperfect half-palindromic estrogen response element and Spl motifs. Cancer Res., 55: 4999-5006, 1995.
12. Li, X-S., Shao, Z-M., Sheikh, M S., Eiseman, J. L., Sentz, D., Jetten, A. M., Chen, J-C., Dawson, M. I., Aisner, S., Rishi, A. K., Gutierrez, P., Schnapper, L., and Fontana, J. A. Retinoic acid nuclear receptor β inhibits breast carcinoma anchorage independent growth. J. Cell Physiol., 165: 449-458, 1995.
13. Sambrook, J., Fritsch, E. F., and Maniatis, T. E Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
14. Sheikh, M S., Shao, Z-M., Clemmons, D. R., LeRoith, D., Roberts, C. T., Jr, and Fontana, J. A. Identification of insulin-like growth factor binding protein-5 and 6 (IGFBP-5 and 6) in human breast cancer cells Biochem. Biophys. Res. Commun., 183: 1003-1010, 1992.
15. Laborda, J. 36B4 cDNA used as an estradiol-mdependent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO Nucleic Acids Res., 19: 3998, 1991.
16. Joseph, L. J., LeBeau, M. M., Jamieson, G. A., Jr., Acharya, S., Shows, T. B., Rowley, J. D., and Sukhatme, V P Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Proc. Natl. Acad. Sci. USA, 85: 7164-7168, 1988.
17. Feinberg, A. P., and Vogelstein, B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 137: 266-267, 1984.
18. Rishi, A. K., Hatzis, D., McAlmon, K., and Floros, J. An allelic variant of the 6A gene for human surfactant protein A. Am. J Physiol. 262: L566-L573, 1992.
19. MacGregor, G. R., Mogg, A E., Burke, J. F., and Caskey, C. K. Histochemical staining of clonal cell lines expressing E. coli β galactosidase indicates heterogenous expression of bacterial gene. Somatic Cell Mol. Genet., 13: 253-265, 1987.
20. Reese, J. C., and Katzenellenbogen, B. S. Examination of DNA binding ability of estrogen receptor in whole cells: implications for hormone independent transactivation and the actions of antiestrogens Mol. Cell Biol., 12: 4531-4538, 1992.
21. Brand, N. J., Petkovich, M., and Chambon, P Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRARα). Nucleic Acids Res., 18: 6799-6806, 1990.
22. Pfeffer, U., Fecarotta, E., and Vidali, G. Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res., 55: 2158-2165, 1995.