Paranodal structure in diabetic sensory polyneuropathy

Acta Neuropathologica

Volumn 92, Issue 6, 1996, Pages 614-620

  Thomas, P K ^a   Beamish, N G ^a   Small, J R ^a   King, R H M ^a   Tesfaye, S ^b   Ward, J D ^b   Tsigos, C ^c   Young, R J ^c   Boulton, A J M ^c  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^c MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Axoglial dysjunction; Diabetic polyneuropathy; Nodes of Ranvier; Paranodes

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DEMYELINATION; DIABETIC NEUROPATHY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NERVE DEGENERATION; PRIORITY JOURNAL; RANVIER NODE; SENSORY NEUROPATHY; SURAL NERVE;

ADULT; DIABETIC NEUROPATHIES; FEMALE; HUMANS; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; PERIPHERAL NERVOUS SYSTEM DISEASES; RANVIER'S NODES; SENSATION DISORDERS; SURAL NERVE;

EID: 0029803755     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050569     Document Type: Article

References (37)

1. Allt G (1969) Repair of segmental demyelination in peripheral nerve. An electron microscope study. Brain 92: 639-649
2. Allt G (1975) The node of Ranvier in experimental allergic neuritis: an electron microscope study. J Neurocytol 4: 63-76
3. Ballin RHM, Thomas PK (1969) Changes at the nodes of Ranvier: an electron microscope study. Acta Neuropathol (Berl) 14: 237-249
4. Ballin RHM, Thomas PK (1969) Electron microscope observations on demyelination and remyelination in experimental allergic neuritis. 1. Demyelination. J Neurol Sci 8: 1-18
5. Ballin RHM, Thomas PK (1969) Electron microscope observations on demyelination and remyelination in experimental allergic neuritis. J Neurol Sci 8: 225-237
6. Baur PS, Stacey TR (1977) The use of PIPES buffer in the fixation of mammalian and marine tissues for electron microscopy. J Microsc 109: 315-327
7. Berthold C-H, Rydmark M (1983) Anatomy of the paranode-node-paranode region in the cat. Experientia 39: 964-976
8. Bertram M, Schröder JM (1993). Developmental changes at the node and paranode in human sural nerves: morphometric and fine-structural analysis. Cell Tissue Res 273: 499-509
9. Chopra JS, Hurwitz LJ, Montgomery DAD (1969) The pathogenesis of sural nerve changes in diabetes mellitus. Brain 92: 391-418
10. Dolman CL (1963) The morbid anatomy of diabetic neuropathy. Neurology 13: 135-142
11. Gabriel G, Thomas PK, King RHM, Stolinski C, Breathnach AS (1986) Freeze-fracture observations on human peripheral nerve. J Anat 146: 153-166
12. Greenbaum D, Richardson PC, Salmon MV, Urich H (1964) Pathological observations on six cases of diabetic neuropathy. Brain 87: 201-214
13. Harkin JC (1964) A series of desmosomal attachments in the Schwann sheath of myelinated mammalian nerves. Z Zellforsch 64: 189-195
14. Hirano A, Dembitzer HA (1982) Further studies on the transverse bands. J Neurocytol 11: 861-869
15. Hirano A, Cook SD, Whitaker JN, Dowling PC, Murray MR (1971) Fine structural aspects of demyelination in vitro. The effects of Guillain-Barré serum. J Neuropathol Exp Neurol 30: 249-256
16. Ishise J, Rosenbluth J (1986) Nodal and paranodal structural changes in frog optic nerve during early Wallerian degeneration. J Neurocytol 15: 657-670
17. Jones HB, Cavanagh JB (1983) Distortions of the nodes of Ranvier from axonal distension by filaments in hexacarbon intoxication. J Neurocytol 12: 439-458
18. King RHM, Pollard JD, Thomas PK (1975) Aberrant remyelination in chronic relapsing experimental allergic neuritis. Neuropathol Appl Neurobiol 1: 367-378
19. Lamontagne A, Buchthal F (1970) Electrophysiological studies in diabetes mellitus. J Neurol Neurosurg Psychiatry 33: 442-450
20. Landon DN, Williams PL (1963) Ultrastructure of the node of Ranvier. Nature 199: 575-581
21. Livingstone RB, Pfenninger K, Moor H, Akert K (1973) Specialized paranodal and interparanodal glial-axonal junctions in the peripheral and central nervous system: a freeze-fracture study. Brain Res 58: 1-24
22. Nageotte J (1922) L'organisation de la matière dans les rapports avec la vie. Felix Alcan, Paris
23. Olsson Y, Säve-Söderbergh K, Sourander P, Angervall L (1968) A pathoanatomical study of the central and peripheral nervous system in diabetes of early onset and long duration. Pathol Eur 3: 62-70
24. Phillips DD, Hibbs RG, Ellison JP, Shapiro H (1972) An electron microscopic study of central and peripheral nodes of Ranvier. J Anat 111: 229-252
25. Said G, Slama G, Selva J (1983) Progressive centripetal degeneration of axons in small fibre diabetic neuropathy. Brain 106: 791-807
26. Said G, Goulon-Goeau C, Slama G, Tchobroutsky G (1992) Severe early-onset polyneuropathy in insulin-dependent diabetes mellitus. N Engl J Med 326: 1257-1263
27. Schnapp B, Mugnaini E (1978) Membrane architecture of myelinated fibers as seen by freeze-fracture. In: Waxman SG (ed) Physiology and pathobiology of axons. Raven Press, New York, pp 83-94
28. Sima AAF, Lattimer SA, Yagihashi S, Greene DA (1986) Axoglial dysjunction. A novel structural lesion that accounts for poorly reversible slowing of nerve conduction in the sponta-neously diabetic bio-breeding rat. J Clin Invest 77: 474-484
29. Sima AAF, Nathaniel V, Bril V, McEwen TAJ, Greene DA (1988) Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes and demonstration of axo-glial dysjunction in human diabetic neuropathy. J Clin Invest 81: 349-364
30. Spencer PS, Thomas PK (1970) The examination of isolated nerve fibres by light and electron microscopy, with observations on demyelination proximal to neuromas. Acta Neuropathol (Berl) 16: 177-186
31. Spencer PS, Thomas PK (1974) Ultrastructural studies on the dying-back process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons. J Neurocytol 3: 763-783
32. Stolinski C, Breathnach AS, Martin B, Thomas PK, King RHM, Gabriel G (1981) Associated particle aggregation in juxtaparanodal axolemma Schwann cell membrane of rat peripheral nerve. J Neurocytol 10: 679-691
33. Sugimura K, Dyck PJ (1982) Multifocal fiber loss in proximal sciatic nerve in symmetric distal diabetic neuropathy. J Neurol Sci 53: 501-509
34. Thomas PK, Lascelles RG (1966) The pathology of diabetic neuropathy. Q J Med 35: 489-496
35. Thomas PK, Ochoa J, Berthold C-H, Carlstedt T, Corneliuson O (1993) Microscopic anatomy of the peripheral nervous system. In: Dyck PJ, Thomas PK (eds) Peripheral neuropathy, 3rd edn. Saunders, Philadelphia, pp 28-92
36. Watkins PJ, Gayle C, Alsanjari N, Scaravilli F, Zanone M, Thomas PK (1995) Severe sensory-autonomic neuropathy and endocrinopathy in insulin-dependent diabetes. Q J Med 88: 795-804
37. Wiley CA, Ellisman MH (1980) Rows of dimeric particles within the axolemma and juxtaposed particles within glia, incorporated into a new model for the paranodal glial-axonal junction at the node of Ranvier. J Cell Biol 84: 261-268