Persistent reduction in IL-6 mRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis after treatment with a monoclonal antibody to CD54 (ICAM-1)

Clinical and Experimental Immunology

Volumn 106, Issue 2, 1996, Pages 190-196

  Schulze Koops, H ^a   Lipsky, P E ^a   Kavanaugh, A F ^a   Davis, L S ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

adhesion molecules; cytokines; immunotherapy; rheumatoid arthritis

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; HUMAN; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

EID: 0029803588     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-828.x     Document Type: Article

References (33)

1. Lipsky PE, Davis LS, Cush JJ, Oppenheimer-Marks N. The role of cytokines in the pathogenesis of rheumatoid arthritis. Springer Semin Immunopathol 1989; 11:123 62.
2. Rothlein R, Mainolfi EA, Kishimoto TK. Treatment of inflammation with anti-ICAM-1. Res Immunol 1993; 144:735 9.
3. Dougherty GJ, Murdoch S, Hogg N. The function of human intercellular adhesion molecule-1 (ICAM-1) in the generation of an immune response. Eur J Immunol 1988; 18:35 9.
4. Mentzer SJ, Rothlein R, Springer TA, Faller DV. Intercellular adhesion molecule-1 (ICAM-1) is involved in the cytolytic T lymphocyte interaction with a human synovial cell line. J Cell Physiol 1988; 137:173 8.
5. Boyd AW, Wawryk SO, Burns GF, Fecondo JV. Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms. Proc Natl Acad Sci USA 1988; 85:3095 9.
6. Spits H, van Schooten W, Keizer H et al. Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells. Science 1986; 232:403 5.
7. Argenhright LW, Barton RW. Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited. J Clin Invest 1992; 89:259 72.
8. Cosimi AB, Conti D, Delmonico FL et al. In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts. J Immunol 1990; 144:4604 12.
9. Flavin T, Ivens K, Rothlcin R et al. Monoclonal antibodies against intercellular adhesion molecule 1 prolong cardiac allograft survival in cynomolgus monkeys. Transplant Proc 1991; 23:533 4.
10. Barton RW, Rothlein R, Ksiazek J, Kennedy C. The effect of anti-intercellular adhesion molecule-1 on phorbol-ester-induced rabbit lung inflammation. J Immunol 1989; 143:1278 82.
11. Clark WM, Madden KP, Rothlein R, Zivin JA. Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule. J Neurosurg 1991; 75:623 7.
12. Jasin HE, Lightfoot E, Davis LS, Rothlein R, Faanes RB, Lipsky PE. Amelioration of antigen-induced arthritis in rabbits treated with monoclonal antibodies to leukocyte adhesion molecules. Arthritis Rheum 1992; 35:541 9.
13. Iigo Y, Takashi T, Tamatani T et al. ICAM-1-dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats. J Immunol 1991; 147:4167 71.
14. Kavanaugh AF, Davis LS, Nichols LA et al Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1. Arthritis Rheum 1994; 37:992 9.
15. Davis LS, Kavanaugh AF, Nichols LA, Lipsky PE. Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis. J Immunol 1995; 154:3525 37.
16. Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS. Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis: modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol 1995; 155:5029 37.
17. Brennan FM, Field M, Chu CQ, Feldmann M, Maini RN. Cytokine expression in rheumatoid arthritis. Br J Rheumatol 1991; 30S1:76 80.
18. Firestein GS, Tsai V, Zvaifler NJ. Cellular immunity in the joints of patients with rheumatoid arthritis and other forms of chronic synovitis. Rheum Dis Clin North Am 1987; 13:191 213.
19. Cush JJ, Lipsky PE. The immunopathogenesis of rheumatoid arthritis: the role of cytokines in chronic inflammation. Clin Aspects Autoimmun 1987; 1:2 12.
20. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315 24.
21. Kavanaugh AF, Davis LS, Jain RI, Nichols LA, Norris SH, Lipsky PE. Anti-ICAM-1 (intercellular adhesion molecule-1: CD54) monoclonal antibody therapy in early rheumatoid arthritis. J Rheumatol 1996; 23: 1338 43.
22. Paulus HE, Egger MJ, Ward JR, Williams HJ and the Cooperative Systemic Studies of Rheumatic Diseases Group. Analysis of improvement in individual rheumatoid arthritis patients treated with disease-modifying antirheumatic drugs, based on the findings in patients treated with placebo. Arthritis Rheum 1990; 33:477 84.
23. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209 20.
24. Cush JJ, Splawski JB, Thomas R et al. Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum 1995; 38: 96 104.
25. Arvidson NG, Gudbjornsson B, Elfman L, Ryden AC, Totterman TH, Hallgren R. Circadian rhythm of serum interleukin-6 in rheumatoid arthritis. Ann Rheum Dis 1994; 53:521 4.
26. Zvaifler NJ, Firestein GS. Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 1994; 37:783 9.
27. Sewell KL, Trentham DE. Pathogenesis of rheumatoid arthritis. Lancet 1993; 341:283 6.
28. Koopman WJ, Gay S. Do nonimmunologically mediated pathways play a role in the pathogenosis of rheumatoid arthritis? Rheum Dis Clin North Am 1993; 19:107 22.
29. Meerschaert J, Furie MB. Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro. J Immunol 1994; 152:1915 26.
30. Rothlein R, Kishimoto TK, Mainolfi E. Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes. J Immunol 1994; 152:2488 95.
31. Holt I, Cooper RG, Hopkins SJ. Relationships between local inflammation, interleukin-6 concentration and the acute phase protein response in arthritis patients. Eur J Clin Invest 1991; 21:479 84.
32. Graeve L, Baumann M, Heinrich PC. Interleukin-6 in autoimmune diseases. Clin Investig 1993; 71:664 71.
33. Firestein GS, Alvaro-Gracia JM, Maki R. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 1990; 144:3347 53.